Third Generation EGFR Inhibitors

Written By Harun M. Patel
Third Generation EGFR Inhibitors
  • Publsiher : Elsevier
  • Release : 27 November 2018
  • ISBN : 0081026625
  • Pages : 208 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Third Generation EGFR Inhibitors written by Harun M. Patel which was release on 27 November 2018, this book published by Elsevier. Available in PDF, EPUB and Kindle Format. Book excerpt: Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems reviews current issues relating to the design of reversible and irreversible third generation EGFR inhibitors, highlighting the types of mutation responsible for resistance, and providing different chemical starting points for researchers to optimize and develop in designing the next generation of drugs. Beginning with an introduction to EGFR inhibitors and a review of inhibitors currently approved or in clinical trials, the book goes on to discuss current approaches in the development of both covalent irreversible and covalent reversible EGFR Inhibitors. In addition, mechanisms of resistance to third generation inhibitors, and discovery of fourth generation allosteric C797S inhibitors are explored before a discussion of potential future trends. This comprehensive coverage of the design and development of improved analogues to overcome the problems of resistance and toxicity associated with third generation EGFR inhibitors makes Third Generation EGFR Inhibitors a crucial resource for medicinal chemists, drug developers, and researchers investigating cancer therapeutics. Includes full synthetic schemes of all approved and in-trial third generation inhibitors Highlights the emergence of fourth generation EGFR inhibitors and the possibilities of them overcoming constraints of third generation compounds Provides a structural correlation of third and fourth generation EGFR inhibitors, reviewing both their design strategies and typical anticancer activity

Third Generation EGFR Inhibitors

Third Generation EGFR Inhibitors
  • Author : Harun M. Patel,Rahul Pawara,Sanjay J. Surana
  • Publisher : Elsevier
  • Release Date : 2018-11-27
  • Total pages : 208
  • ISBN : 0081026625
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Summary : Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems reviews current issues relating to the design of reversible and irreversible third generation EGFR inhibitors, highlighting the types of mutation responsible for resistance, and providing different chemical starting points for researchers to optimize and develop in designing the next generation ...

Third Generation EGFR Inhibitors

Third Generation EGFR Inhibitors
  • Author : Harun M. Patel,Rahul Pawara,S. J. Surana
  • Publisher : Elsevier
  • Release Date : 2019-03-15
  • Total pages : 290
  • ISBN : 0081026625
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Summary : EGFR inhibitors are useful tools in cancer therapeutics, but resistance to the first generations have significantly increased, meaning a new generation of improved inhibitors are needed with better efficacy and lower toxicity. Third Generation EGFR Inhibitors: Overcoming EGFR Resistance and Toxicity Problems reviews current issues relating to the design of ...

Acquired Resistance to Targeted Therapy in EGFR mutant Lung Adenocarcinoma

Acquired Resistance to Targeted Therapy in EGFR mutant Lung Adenocarcinoma
  • Author : Caroline Amalia Nebhan
  • Publisher : Unknown
  • Release Date : 2014
  • Total pages : 145
  • ISBN : 0081026625
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Summary : Download or read online Acquired Resistance to Targeted Therapy in EGFR mutant Lung Adenocarcinoma written by Caroline Amalia Nebhan, published by which was released on 2014. Get Acquired Resistance to Targeted Therapy in EGFR mutant Lung Adenocarcinoma Books now! Available in PDF, ePub and Kindle....

Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC

Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC
  • Author : Anthony Faber
  • Publisher : Academic Press
  • Release Date : 2021-03-15
  • Total pages : 250
  • ISBN : 0081026625
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Summary : Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC, Volume 17 presents updated information on how EGFR mutant lung cancers evolve to evade EGFR inhibitors, clinical strategies that identify these mechanisms, and how to implement newer therapeutic strategies to combat resistance and improve patient survival. As resistance to EGFR inhibitors is ...

Frontiers in Anti Cancer Drug Discovery Volume 11

Frontiers in Anti Cancer Drug Discovery  Volume 11
  • Author : Atta-ur-Rahman ,Muhammad Iqbal Choudhary
  • Publisher : Bentham Science Publishers
  • Release Date : 2020-09-01
  • Total pages : 163
  • ISBN : 0081026625
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Summary : Frontiers in Anti-Cancer Drug Discovery is a book series devoted to publishing the latest advances in anti-cancer drug design and discovery. In each volume, eminent scientists contribute reviews relevant to all areas of rational drug design and drug discovery including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug ...

A Beginner s Guide to Targeted Cancer Treatments

A Beginner s Guide to Targeted Cancer Treatments
  • Author : Elaine Vickers
  • Publisher : John Wiley & Sons
  • Release Date : 2018-05-08
  • Total pages : 360
  • ISBN : 0081026625
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Summary : The accessible guide to the principles behind new, more targeted drug treatments for cancer Written for anyone who encounters cancer patients, cancer data or cancer terminology, but have no more than a passing knowledge of cell biology. A Beginner's Guide to Targeted Cancer Treatments provides an understanding of how cancer ...

Chemoinformatics Approaches to Structure and Ligand Based Drug Design

Chemoinformatics Approaches to Structure  and Ligand Based Drug Design
  • Author : Adriano D. Andricopulo,Leonardo L. G. Ferreira
  • Publisher : Frontiers Media SA
  • Release Date : 2019-02-05
  • Total pages : 212
  • ISBN : 0081026625
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Summary : Chemoinformatics is paramount to current drug discovery. Structure- and ligand-based drug design strategies have been used to uncover hidden patterns in large amounts of data, and to disclose the molecular aspects underlying ligand-receptor interactions. This Research Topic aims to share with a broad audience the most recent trends in the ...

Practical Medical Oncology Textbook

Practical Medical Oncology Textbook
  • Author : Antonio Russo
  • Publisher : Springer Nature
  • Release Date : 2021-10-19
  • Total pages : 212
  • ISBN : 0081026625
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Summary : Download or read online Practical Medical Oncology Textbook written by Antonio Russo, published by Springer Nature which was released on . Get Practical Medical Oncology Textbook Books now! Available in PDF, ePub and Kindle....

Targeted Therapies for Lung Cancer

Targeted Therapies for Lung Cancer
  • Author : Ravi Salgia
  • Publisher : Springer
  • Release Date : 2019-06-26
  • Total pages : 238
  • ISBN : 0081026625
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Summary : This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights ...

AACR 2016 Abstracts 2697 5293

AACR 2016  Abstracts 2697 5293
  • Author : American Association for Cancer Research (AACR)
  • Publisher : CTI Meeting Technology
  • Release Date : 2016-03-28
  • Total pages : 212
  • ISBN : 0081026625
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Summary : The AACR Annual Meeting is a must-attend event for cancer researchers and the broader cancer community. This year's theme, "Delivering Cures Through Cancer Science," reinforces the inextricable link between research and advances in patient care. The theme will be evident throughout the meeting as the latest, most exciting discoveries are ...

Proteinkinase Inhibitors

Proteinkinase Inhibitors
  • Author : Stefan Laufer
  • Publisher : Springer Nature
  • Release Date : 2021-10-19
  • Total pages : 212
  • ISBN : 0081026625
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Summary : Download or read online Proteinkinase Inhibitors written by Stefan Laufer, published by Springer Nature which was released on . Get Proteinkinase Inhibitors Books now! Available in PDF, ePub and Kindle....

AACR 2016 Abstracts 1 2696

AACR 2016  Abstracts 1 2696
  • Author : American Association for Cancer Research (AACR)
  • Publisher : CTI Meeting Technology
  • Release Date : 2016-03-28
  • Total pages : 212
  • ISBN : 0081026625
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Summary : The AACR Annual Meeting is a must-attend event for cancer researchers and the broader cancer community. This year's theme, "Delivering Cures Through Cancer Science," reinforces the inextricable link between research and advances in patient care. The theme will be evident throughout the meeting as the latest, most exciting discoveries are ...

Lung Cancer

Lung Cancer
  • Author : Anne C. Chiang
  • Publisher : Springer Nature
  • Release Date : 2021-10-19
  • Total pages : 212
  • ISBN : 0081026625
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Summary : Download or read online Lung Cancer written by Anne C. Chiang, published by Springer Nature which was released on . Get Lung Cancer Books now! Available in PDF, ePub and Kindle....

AACR 2018 Proceedings Abstracts 1 3027

AACR 2018 Proceedings  Abstracts 1 3027
  • Author : American Association for Cancer Research
  • Publisher : CTI Meeting Technology
  • Release Date : 2018-04-10
  • Total pages : 212
  • ISBN : 0081026625
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Summary : Download or read online AACR 2018 Proceedings Abstracts 1 3027 written by American Association for Cancer Research, published by CTI Meeting Technology which was released on 2018-04-10. Get AACR 2018 Proceedings Abstracts 1 3027 Books now! Available in PDF, ePub and Kindle....

Molecular Targeted Therapy of Lung Cancer

Molecular Targeted Therapy of Lung Cancer
  • Author : Yuichi Takiguchi
  • Publisher : Springer
  • Release Date : 2017-01-24
  • Total pages : 327
  • ISBN : 0081026625
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Summary : This book discusses the latest molecular targeted therapy of lung cancer including its evaluation and future directions. It clearly illustrates the initial dramatic effectiveness of molecular targeted therapy, recurrence of the disease, overcoming the wide variety of resistance mechanisms using new-generation molecular targeted agents and potential novel approaches. It also ...