Therapeutic Antibody Engineering

Written By William R Strohl
Therapeutic Antibody Engineering
  • Publsiher : Elsevier
  • Release : 16 October 2012
  • ISBN : 1908818093
  • Pages : 696 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Therapeutic Antibody Engineering written by William R Strohl which was release on 16 October 2012, this book published by Elsevier. Available in PDF, EPUB and Kindle Format. Book excerpt: The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that various genetic engineering approaches will have on future candidates. Chapters in the first part of the book provide an introduction to monoclonal antibodies, their discovery and development and the fundamental technologies used in their production. Following chapters cover a number of specific issues relating to different aspects of antibody engineering, including variable chain engineering, targets and mechanisms of action, classes of antibody and the use of antibody fragments, among many other topics. The last part of the book examines development issues, the interaction of human IgGs with non-human systems, and cell line development, before a conclusion looking at future issues affecting the field of therapeutic antibody engineering. Goes beyond the standard engineering issues covered by most books and delves into structure-function relationships Integration of knowledge across all areas of antibody engineering, development, and marketing Discusses how current and future genetic engineering of cell lines will pave the way for much higher productivity

Therapeutic Antibody Engineering

Therapeutic Antibody Engineering
  • Author : William R Strohl,Lila M Strohl
  • Publisher : Elsevier
  • Release Date : 2012-10-16
  • Total pages : 696
  • ISBN : 1908818093
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Summary : The field of antibody engineering has become a vital and integral part of making new, improved next generation therapeutic monoclonal antibodies, of which there are currently more than 300 in clinical trials across several therapeutic areas. Therapeutic antibody engineering examines all aspects of engineering monoclonal antibodies and analyses the effect that ...

Diagnostic and Therapeutic Antibodies

Diagnostic and Therapeutic Antibodies
  • Author : Andrew J. T. George,Catherine E. Urch
  • Publisher : Springer Science & Business Media
  • Release Date : 2000
  • Total pages : 477
  • ISBN : 1908818093
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Summary : Soon after the first description of monoclonal antibodies in 1976, there was enormous interest in the clinical application of antibodies, especially in the context of cancer. Antibodies appeared to offer the "magic bullet" that would allow the specific destruction of neoplastic cells. H- ever, many years' effort resulted in very few ...

Antibody Engineering

Antibody Engineering
  • Author : Thomas Böldicke
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-02-21
  • Total pages : 312
  • ISBN : 1908818093
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Summary : Antibody Engineering comprises in vitro selection and modification of human antibodies including humanization of mouse antibodies for therapy, diagnosis, and research. This book comprises an overview about the generation of antibody diversity and essential techniques in antibody engineering: construction of immune, naive and synthetic libraries, all available in vitro display ...

Antibody Engineering

Antibody Engineering
  • Author : Benny K. C. Lo
  • Publisher : Humana Press
  • Release Date : 2010-10-28
  • Total pages : 562
  • ISBN : 1908818093
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Summary : The exquisite binding specificity of antibodies has made them valuable tools from the laboratory to the clinic. Since the description of the murine hybridoma technology by Köhler and Milstein in 1975, a phenomenal number of mo- clonal antibodies have been generated against a diverse array of targets. Some of these ...

Antibody Engineering

Antibody Engineering
  • Author : Roland E. Kontermann,Stefan Dübel
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-03-10
  • Total pages : 788
  • ISBN : 1908818093
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Summary : Antibodies are indispensable tools for research, diagnosis, and therapy. Recombinant approaches allow the modification and improvement of nearly all antibody properties, such as affinity, valency, specificity, stability, serum half-life, effector functions, and immunogenicity. "Antibody Engineering" provides a comprehensive toolbox covering the well-established basics but also many exciting new techniques. The ...

Therapeutic Antibodies

Therapeutic Antibodies
  • Author : Antony S. Dimitrov
  • Publisher : Humana Press
  • Release Date : 2014-11-25
  • Total pages : 585
  • ISBN : 1908818093
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Summary : Over 2000 years ago in China, antibodies elicited by early forms of vaccination likely played a major role in the protection of the population from infectious agents. Vac- nation has been further developed in Europe and described by Edward Jenner in the late-eighteenth century, then successfully implemented worldwide. The idea to ...

Introduction to Antibody Engineering

Introduction to Antibody Engineering
  • Author : Florian Rüker,Gordana Wozniak-Knopp
  • Publisher : Springer Nature
  • Release Date : 2021-01-04
  • Total pages : 388
  • ISBN : 1908818093
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Summary : This highly readable textbook serves as a concise and engaging primer to the emerging field of antibody engineering and its various applications. It introduces readers to the basic science and molecular structure of antibodies, and explores how to characterize and engineer them. Readers will find an overview of the latest ...

Handbook of Therapeutic Antibodies

Handbook of Therapeutic Antibodies
  • Author : Stefan Dübel,Janice M. Reichert
  • Publisher : John Wiley & Sons
  • Release Date : 2014-12-03
  • Total pages : 2544
  • ISBN : 1908818093
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Summary : Still the most comprehensive reference source on the development, production and therapeutic application of antibodies, this second edition is thoroughly updated and now has 30% more content. Volume I covers selection and engineering strategies for new antibodies, while the second volume look at novel therapeutic concepts and antibodies in clinical trial ...

Therapeutic Monoclonal Antibodies

Therapeutic Monoclonal Antibodies
  • Author : Zhiqiang An
  • Publisher : John Wiley & Sons
  • Release Date : 2011-09-20
  • Total pages : 896
  • ISBN : 1908818093
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Summary : 70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety. Most chapters contain experimental data to illustrate the principles described in them. Authors provide detailed methodologies ...

Applications And Engineering Of Monoclonal Antibodies

Applications And Engineering Of Monoclonal Antibodies
  • Author : David J. King
  • Publisher : CRC Press
  • Release Date : 1998-11-27
  • Total pages : 249
  • ISBN : 1908818093
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Summary : A valuable resource for researchers and workers in the fields of both pharmaceuticals and biotechnology as well as undergraduates in biochemistry, applied biology, biomedical sciences and pharmacy, this book compares established techniques of antibody production with the new. Antibody structure and the implications of antibody engineering are fully discussed, and ...

Therapeutic Antibodies

Therapeutic Antibodies
  • Author : Yuti Chernajovsky,Ahuva Nissim
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-12-11
  • Total pages : 380
  • ISBN : 1908818093
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Summary : This essential work, edited by two researchers at London’s famous Queen Mary’s medical school targets one of the most important areas in medical development today. These days, antibody therapeutics are the treatment of choice for several autoimmune and oncological conditions. They are, indeed, becoming the molecules of choice ...

Identification of a Novel Cancer Therapeutic Antibody Against Human Epidermal Growth Factor Receptor 2 Her2 and Antibody Engineering for Development of Cancer Therapeutics

Identification of a Novel Cancer Therapeutic Antibody Against Human Epidermal Growth Factor Receptor 2  Her2  and Antibody Engineering for Development of Cancer Therapeutics
  • Author : Chao Chen
  • Publisher : Unknown
  • Release Date : 2017-01-26
  • Total pages : 212
  • ISBN : 1908818093
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Summary : Download or read online Identification of a Novel Cancer Therapeutic Antibody Against Human Epidermal Growth Factor Receptor 2 Her2 and Antibody Engineering for Development of Cancer Therapeutics written by Chao Chen, published by which was released on 2017-01-26. Get Identification of a Novel Cancer Therapeutic Antibody Against Human Epidermal Growth ...

Antibody Fc Engineering Towards Better Therapeutics

Antibody Fc Engineering  Towards Better Therapeutics
  • Author : Tianlei Ying,Rui Gong
  • Publisher : Frontiers Media SA
  • Release Date : 2018-12-21
  • Total pages : 212
  • ISBN : 1908818093
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Summary : Download or read online Antibody Fc Engineering Towards Better Therapeutics written by Tianlei Ying,Rui Gong, published by Frontiers Media SA which was released on 2018-12-21. Get Antibody Fc Engineering Towards Better Therapeutics Books now! Available in PDF, ePub and Kindle....

Identification of a Novel Cancer Therapeutic Antibody Against Human Epidermal Growth Factor Receptor 2 Her2 and Antibody Engineering for Development of Cancer Therapeutics

Identification of a Novel Cancer Therapeutic Antibody Against Human Epidermal Growth Factor Receptor 2  Her2  and Antibody Engineering for Development of Cancer Therapeutics
  • Author : 陳超,University of Hong Kong
  • Publisher : Unknown
  • Release Date : 2013
  • Total pages : 372
  • ISBN : 1908818093
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Summary : Download or read online Identification of a Novel Cancer Therapeutic Antibody Against Human Epidermal Growth Factor Receptor 2 Her2 and Antibody Engineering for Development of Cancer Therapeutics written by 陳超,University of Hong Kong, published by which was released on 2013. Get Identification of a Novel Cancer Therapeutic Antibody Against Human Epidermal Growth ...

Antibody Engineering

Antibody Engineering
  • Author : Patrick Chames
  • Publisher : Humana Press
  • Release Date : 2016-08-23
  • Total pages : 734
  • ISBN : 1908818093
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Summary : More than ever, antibodies are being recognized as a major drug modality in a variety of diseases, including cancer, autoimmune diseases, infectious diseases, or even neurodegenerative disorders. Over 30 therapeutic antibodies have been approved and novel molecules are entering clinical trials at an average rate of 50 per year and that is ...