The History of Alternative Test Methods in Toxicology

Written By Anonim
The History of Alternative Test Methods in Toxicology
  • Publsiher : Academic Press
  • Release : 20 October 2018
  • ISBN : 0128136987
  • Pages : 352 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled The History of Alternative Test Methods in Toxicology written by Anonim which was release on 20 October 2018, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.

The History of Alternative Test Methods in Toxicology

The History of Alternative Test Methods in Toxicology
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2018-10-20
  • Total pages : 352
  • ISBN : 0128136987
GET BOOK

Summary : The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history ...

Information Resources in Toxicology

Information Resources in Toxicology
  • Author : Steve Gilbert,Asish Mohapatra,Sol Bobst,Antoinette Hayes,Sara T. Humes
  • Publisher : Academic Press
  • Release Date : 2020-05-16
  • Total pages : 1054
  • ISBN : 0128136987
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Summary : This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, ...

An Introduction to Interdisciplinary Toxicology

An Introduction to Interdisciplinary Toxicology
  • Author : Carey N. Pope,Jing Liu
  • Publisher : Academic Press
  • Release Date : 2020-02
  • Total pages : 644
  • ISBN : 0128136987
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Summary : An Introduction to Interdisciplinary Toxicology: From Molecules to Man integrates the various aspects of toxicology, from "simple" molecular systems, to complex human communities, with expertise from a spectrum of interacting disciplines. Chapters are written by specialists within a given subject, such as a chemical engineer, nutritional scientist, or a microbiologist, ...

Prof of Drug Substances Excipients and Related Methodology

Prof  of Drug Substances  Excipients and Related Methodology
  • Author : Abdulrahman Al-Majed
  • Publisher : Academic Press
  • Release Date : 2021-01-16
  • Total pages : 326
  • ISBN : 0128136987
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Summary : Profiles of Drug Substances, Excipients, and Related Methodology, Volume 46 contains comprehensive profiles of five drug compounds: Darunavir, Bisoprolol, Betaxolol, Rabeprazole and Irbesartan. In addition, the work contains a chapter reviewing Bioassay Methods and Their Applications in Herbal Drug Research. The comprehensive reviews in the book cover all aspects of drug ...

Big Data in Predictive Toxicology

Big Data in Predictive Toxicology
  • Author : Andrea-Nicole Richarz,Daniel Neagu
  • Publisher : Royal Society of Chemistry
  • Release Date : 2019-12-10
  • Total pages : 394
  • ISBN : 0128136987
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Summary : The rate at which toxicological data is generated is continually becoming more rapid and the volume of data generated is growing dramatically. This is due in part to advances in software solutions and cheminformatics approaches which increase the availability of open data from chemical, biological and toxicological and high throughput ...

Toxicology in Antiquity

Toxicology in Antiquity
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2018-10-22
  • Total pages : 510
  • ISBN : 0128136987
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Summary : Toxicology in Antiquity provides an authoritative and fascinating exploration into the use of toxins and poisons in antiquity. It brings together the two previously published shorter volumes on the topic, as well as adding considerable new information. Part of the History of Toxicology and Environmental Health series, it covers key ...

Computational Nanotoxicology

Computational Nanotoxicology
  • Author : Agnieszka Gajewicz,Tomasz Puzyn
  • Publisher : CRC Press
  • Release Date : 2019-11-13
  • Total pages : 552
  • ISBN : 0128136987
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Summary : The development of computational methods that support human health and environmental risk assessment of engineered nanomaterials (ENMs) has attracted great interest because the application of these methods enables us to fill existing experimental data gaps. However, considering the high degree of complexity and multifunctionality of ENMs, computational methods originally developed ...

Handbook of Laboratory Animal Science

Handbook of Laboratory Animal Science
  • Author : Jann Hau,Steven J. Schapiro
  • Publisher : CRC Press
  • Release Date : 2021-05-17
  • Total pages : 1012
  • ISBN : 0128136987
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Summary : Building upon the success of previous editions of the bestselling Handbook of Laboratory Animal Science, first published in 1994, this latest revision combines all three volumes in one definitive guide. It covers the essential principles and practices of Laboratory Animal Science as well as selected animal models in scientific disciplines where ...

Organ on a chip

Organ on a chip
  • Author : Julia Hoeng,David Bovard,Manuel Peitsch
  • Publisher : Academic Press
  • Release Date : 2019-11-09
  • Total pages : 546
  • ISBN : 0128136987
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Summary : Organ-on-a-Chip: Engineered Microenvironments for Safety and Efficacy Testing contains chapters from world-leading researchers in the field of organ on a chip development and applications, with perspectives from life sciences, medicine, physiology and engineering. The book contains an overview of the field, with sections covering the major organ systems and currently ...

Hayes Principles and Methods of Toxicology Sixth Edition

Hayes  Principles and Methods of Toxicology  Sixth Edition
  • Author : A. Wallace Hayes,Claire L. Kruger
  • Publisher : CRC Press
  • Release Date : 2014-10-10
  • Total pages : 2184
  • ISBN : 0128136987
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Summary : Hayes’ Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With ...

Principles and Methods of Toxicology Fifth Edition

Principles and Methods of Toxicology  Fifth Edition
  • Author : A. Wallace Hayes
  • Publisher : CRC Press
  • Release Date : 2007-09-25
  • Total pages : 2296
  • ISBN : 0128136987
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Summary : Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and ...

Molecular Clinical and Environmental Toxicology

Molecular  Clinical and Environmental Toxicology
  • Author : Andreas Luch
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-03-01
  • Total pages : 619
  • ISBN : 0128136987
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Summary : Clinical Toxicology is the second volume of a three-volume set on molecular, clinical and environmental toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals of daily life. By providing intriguing insights far down to the molecular level, this three-volume work covers the entire ...

Validation of Alternative Methods for Toxicity Testing

Validation of Alternative Methods for Toxicity Testing
  • Author : Chantra Eskes,Maurice Whelan
  • Publisher : Springer
  • Release Date : 2016-09-26
  • Total pages : 407
  • ISBN : 0128136987
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Summary : This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem ...

Departments of Labor and Health and Human Services Education and Related Agencies Appropriations

Departments of Labor  and Health and Human Services  Education  and Related Agencies Appropriations
  • Author : United States. Congress. Senate. Committee on Appropriations
  • Publisher : Unknown
  • Release Date : 2006
  • Total pages : 212
  • ISBN : 0128136987
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Summary : Download or read online Departments of Labor and Health and Human Services Education and Related Agencies Appropriations written by United States. Congress. Senate. Committee on Appropriations, published by which was released on 2006. Get Departments of Labor and Health and Human Services Education and Related Agencies Appropriations Books now! Available in ...

Senate Hearings Before the Committee on Appropriations

Senate Hearings Before the Committee on Appropriations
  • Author : Anonim
  • Publisher : DIANE Publishing
  • Release Date : 2021-12-01
  • Total pages : 212
  • ISBN : 0128136987
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Summary : Download or read online Senate Hearings Before the Committee on Appropriations written by , published by DIANE Publishing which was released on . Get Senate Hearings Before the Committee on Appropriations Books now! Available in PDF, ePub and Kindle....