The History of Alternative Test Methods in Toxicology

Written By Anonim
The History of Alternative Test Methods in Toxicology
  • Publsiher : Academic Press
  • Release : 20 October 2018
  • ISBN : 0128136987
  • Pages : 352 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled The History of Alternative Test Methods in Toxicology written by Anonim which was release on 20 October 2018, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.

The History of Alternative Test Methods in Toxicology

The History of Alternative Test Methods in Toxicology
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2018-10-20
  • Total pages : 352
  • ISBN : 0128136987
GET BOOK

Summary : The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history ...

Principles of Toxicology

Principles of Toxicology
  • Author : Stephen M. Roberts,Robert C. James,Phillip L. Williams
  • Publisher : John Wiley & Sons
  • Release Date : 2022-04-26
  • Total pages : 592
  • ISBN : 0128136987
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Summary : Principles of Toxicology concisely and efficiently presents the scientific basis for toxicology as it applies to the workplace and the environment, covering diverse chemical hazards encountered in modern workplaces and natural environments and providing a practical understanding of these hazards for those concerned with protecting the health of humans and ...

Information Resources in Toxicology

Information Resources in Toxicology
  • Author : Steve Gilbert,Asish Mohapatra,Sol Bobst,Antoinette Hayes,Sara T. Humes
  • Publisher : Academic Press
  • Release Date : 2020-05-16
  • Total pages : 1054
  • ISBN : 0128136987
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Summary : This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, ...

An Introduction to Interdisciplinary Toxicology

An Introduction to Interdisciplinary Toxicology
  • Author : Carey N. Pope,Jing Liu
  • Publisher : Academic Press
  • Release Date : 2020-02
  • Total pages : 644
  • ISBN : 0128136987
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Summary : An Introduction to Interdisciplinary Toxicology: From Molecules to Man integrates the various aspects of toxicology, from "simple" molecular systems, to complex human communities, with expertise from a spectrum of interacting disciplines. Chapters are written by specialists within a given subject, such as a chemical engineer, nutritional scientist, or a microbiologist, ...

Prof of Drug Substances Excipients and Related Methodology

Prof  of Drug Substances  Excipients and Related Methodology
  • Author : Abdulrahman Al-Majed
  • Publisher : Academic Press
  • Release Date : 2021-01-16
  • Total pages : 326
  • ISBN : 0128136987
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Summary : Profiles of Drug Substances, Excipients, and Related Methodology, Volume 46 contains comprehensive profiles of five drug compounds: Darunavir, Bisoprolol, Betaxolol, Rabeprazole and Irbesartan. In addition, the work contains a chapter reviewing Bioassay Methods and Their Applications in Herbal Drug Research. The comprehensive reviews in the book cover all aspects of drug ...

Big Data in Predictive Toxicology

Big Data in Predictive Toxicology
  • Author : Andrea-Nicole Richarz,Daniel Neagu
  • Publisher : Royal Society of Chemistry
  • Release Date : 2019-12-10
  • Total pages : 394
  • ISBN : 0128136987
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Summary : The rate at which toxicological data is generated is continually becoming more rapid and the volume of data generated is growing dramatically. This is due in part to advances in software solutions and cheminformatics approaches which increase the availability of open data from chemical, biological and toxicological and high throughput ...

Computational Nanotoxicology

Computational Nanotoxicology
  • Author : Agnieszka Gajewicz,Tomasz Puzyn
  • Publisher : CRC Press
  • Release Date : 2019-11-13
  • Total pages : 552
  • ISBN : 0128136987
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Summary : The development of computational methods that support human health and environmental risk assessment of engineered nanomaterials (ENMs) has attracted great interest because the application of these methods enables us to fill existing experimental data gaps. However, considering the high degree of complexity and multifunctionality of ENMs, computational methods originally developed ...

Handbook of Laboratory Animal Science

Handbook of Laboratory Animal Science
  • Author : Jann Hau,Steven J. Schapiro
  • Publisher : CRC Press
  • Release Date : 2021-05-17
  • Total pages : 1012
  • ISBN : 0128136987
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Summary : Building upon the success of previous editions of the bestselling Handbook of Laboratory Animal Science, first published in 1994, this latest revision combines all three volumes in one definitive guide. It covers the essential principles and practices of Laboratory Animal Science as well as selected animal models in scientific disciplines where ...

Pharmacokinetics and Toxicokinetic Considerations Vol II

Pharmacokinetics and Toxicokinetic Considerations   Vol II
  • Author : Rakesh Kumar Tekade
  • Publisher : Academic Press
  • Release Date : 2022-02-17
  • Total pages : 814
  • ISBN : 0128136987
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Summary : Pharmacokinetics and Toxicokinetic Considerations explains the central principles, cutting-edge methodologies, and incipient thought processes applied to toxicology research. As part of the Advances in Pharmaceutical Product Development and Research series, the book provides expert literature on dose, dosage regimen and dose adjustment, medication errors, and approaches for its prevention, the ...

Hayes Principles and Methods of Toxicology Sixth Edition

Hayes  Principles and Methods of Toxicology  Sixth Edition
  • Author : A. Wallace Hayes,Claire L. Kruger
  • Publisher : CRC Press
  • Release Date : 2014-10-10
  • Total pages : 2184
  • ISBN : 0128136987
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Summary : Hayes’ Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With ...

Nanomaterials Synthesis Characterization Hazards and Safety

Nanomaterials  Synthesis  Characterization  Hazards and Safety
  • Author : Muhammad Bilal Tahir,Muhammad Sagir,Abdullah M. Asiri
  • Publisher : Elsevier
  • Release Date : 2021-02-16
  • Total pages : 302
  • ISBN : 0128136987
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Summary : Nanomaterials: Synthesis, Characterization, Hazards and Safety explains the fundamental properties of nanomaterials, covering their types and classifications. The book includes methods of preparation and characterization of nanostructured materials. It explains the principles and fundamentals of nanomaterials, with information on both pure and composite-based materials with e nanostructures, outlines the latest ...

Principles and Methods of Toxicology Fifth Edition

Principles and Methods of Toxicology  Fifth Edition
  • Author : A. Wallace Hayes
  • Publisher : CRC Press
  • Release Date : 2007-09-25
  • Total pages : 2304
  • ISBN : 0128136987
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Summary : Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and ...

Validation of Alternative Methods for Toxicity Testing

Validation of Alternative Methods for Toxicity Testing
  • Author : Chantra Eskes,Maurice Whelan
  • Publisher : Springer
  • Release Date : 2016-09-26
  • Total pages : 407
  • ISBN : 0128136987
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Summary : This book provides information on best practices and new thinking regarding the validation of alternative methods for toxicity testing. It covers the validation of experimental and computational methods and integrated approaches to testing and assessment. Validation strategies are discussed for methods employing the latest technologies such as tissue-on-a-chip systems, stem ...

Reducing Refining and Replacing the Use of Animals in Toxicity Testing

Reducing  Refining and Replacing the Use of Animals in Toxicity Testing
  • Author : Dave Allen,Mike D Waters
  • Publisher : Royal Society of Chemistry
  • Release Date : 2013-10-31
  • Total pages : 362
  • ISBN : 0128136987
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Summary : Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain ...

Molecular Clinical and Environmental Toxicology

Molecular  Clinical and Environmental Toxicology
  • Author : Andreas Luch
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-03-01
  • Total pages : 619
  • ISBN : 0128136987
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Summary : Clinical Toxicology is the second volume of a three-volume set on molecular, clinical and environmental toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals of daily life. By providing intriguing insights far down to the molecular level, this three-volume work covers the entire ...