The History of Alternative Test Methods in Toxicology

Written By Anonim
The History of Alternative Test Methods in Toxicology
  • Publsiher : Academic Press
  • Release : 20 October 2018
  • ISBN : 0128136987
  • Pages : 352 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled The History of Alternative Test Methods in Toxicology written by Anonim which was release on 20 October 2018, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement,Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated, miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing, capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialized areas, such as inhalation toxicity studies. The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history of alternative test development, validation, and use, with an emphasis on humanity and good science, in line with the Three Rs (Replacement, Reduction, Refinement) concept expounded by William Russell and Rex Burch in 1959 in their now-classic volume, The Principles of Humane Experimental Technique. The book describes the historical development of technologies that have influenced the application of alternatives in toxicology and safety testing. These range from single cell monocultures to sophisticated miniaturised and microfluidic organism-on-a-chip devices, and also include molecular modelling, chemoinformatics and QSAR analysis, and the use of stem cells, tissue engineering and hollow fibre bioreactors. This has been facilitated by the wider availability of human tissues, advances in tissue culture, analytical and diagnostic methods, increases in computational processing capabilities, and a greater understanding of cell biology and molecular mechanisms of toxicity. These technological developments have enhanced the range and information content of the toxicity endpoints detected, and therefore the relevance of test systems and data interpretation, while new techniques for non-invasive diagnostic imaging and high resolution detection methods have permitted an increased role for human studies. Several key examples of how these technologies are being harnessed to meet 21st century safety assessment challenges are provided, including their deployment in integrated testing schemes in conjunction with kinetic modelling, and in specialised areas, such as inhalation toxicity studies.

The History of Alternative Test Methods in Toxicology

The History of Alternative Test Methods in Toxicology
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2018-10-20
  • Total pages : 352
  • ISBN : 0128136987
GET BOOK

Summary : The History of Alternative Test Methods in Toxicology uses a chronological approach to demonstrate how the use of alternative methods has evolved from their conception as adjuncts to traditional animal toxicity tests to replacements for them. This volume in the History of Toxicology and Environmental Health series explores the history ...

Alternative Toxicological Methods

Alternative Toxicological Methods
  • Author : Harry Salem,Sidney A. Katz
  • Publisher : CRC Press
  • Release Date : 2003-03-26
  • Total pages : 616
  • ISBN : 0128136987
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Summary : Bringing together the recent and relevant contributions of over 125 scientists from industry, government, and academia in North America and Western Europe, Alternative Toxicological Methods explores the development and validation of replacement, reduction, and refinement alternatives (the 3Rs) to animal testing. Internationally recognized scientist...

Information Resources in Toxicology

Information Resources in Toxicology
  • Author : Steve Gilbert,Asish Mohapatra,Sol Bobst,Antoinette Hayes,Sara T. Humes
  • Publisher : Academic Press
  • Release Date : 2020-05-16
  • Total pages : 1054
  • ISBN : 0128136987
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Summary : This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, ...

Principles and Methods of Toxicology Fifth Edition

Principles and Methods of Toxicology  Fifth Edition
  • Author : A. Wallace Hayes
  • Publisher : CRC Press
  • Release Date : 2007-09-25
  • Total pages : 2296
  • ISBN : 0128136987
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Summary : Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and ...

Hazardous Waste Hazardous Materials

Hazardous Waste   Hazardous Materials
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1988
  • Total pages : 212
  • ISBN : 0128136987
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Summary : Download or read online Hazardous Waste Hazardous Materials written by , published by which was released on 1988. Get Hazardous Waste Hazardous Materials Books now! Available in PDF, ePub and Kindle....

Proceedings of the Indian National Science Academy

Proceedings of the Indian National Science Academy
  • Author : Indian National Science Academy
  • Publisher : Unknown
  • Release Date : 2001
  • Total pages : 212
  • ISBN : 0128136987
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Summary : Download or read online Proceedings of the Indian National Science Academy written by Indian National Science Academy, published by which was released on 2001. Get Proceedings of the Indian National Science Academy Books now! Available in PDF, ePub and Kindle....

Proceedings

Proceedings
  • Author : Indian National Science Academy
  • Publisher : Unknown
  • Release Date : 2001
  • Total pages : 212
  • ISBN : 0128136987
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Summary : Download or read online Proceedings written by Indian National Science Academy, published by which was released on 2001. Get Proceedings Books now! Available in PDF, ePub and Kindle....

Animals and Alternatives in Testing

Animals and Alternatives in Testing
  • Author : Joanne Zurlo,Deborah Rudacille,Alan M. Goldberg
  • Publisher : Unknown
  • Release Date : 1994
  • Total pages : 86
  • ISBN : 0128136987
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Summary : Download or read online Animals and Alternatives in Testing written by Joanne Zurlo,Deborah Rudacille,Alan M. Goldberg, published by which was released on 1994. Get Animals and Alternatives in Testing Books now! Available in PDF, ePub and Kindle....

United States Code

United States Code
  • Author : United States
  • Publisher : Unknown
  • Release Date : 2001
  • Total pages : 212
  • ISBN : 0128136987
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Summary : Download or read online United States Code written by United States, published by which was released on 2001. Get United States Code Books now! Available in PDF, ePub and Kindle....

United States Code Annotated

United States Code Annotated
  • Author : United States
  • Publisher : Unknown
  • Release Date : 1927
  • Total pages : 212
  • ISBN : 0128136987
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Summary : Download or read online United States Code Annotated written by United States, published by which was released on 1927. Get United States Code Annotated Books now! Available in PDF, ePub and Kindle....

Non Animal Techniques in Biomedical and Behavioral Research and Testing

Non Animal Techniques in Biomedical and Behavioral Research and Testing
  • Author : Michael Kapis,Shayne C. Gad
  • Publisher : CRC Press
  • Release Date : 1993-06-24
  • Total pages : 288
  • ISBN : 0128136987
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Summary : Non-Animal Techniques in Biomedical and Behavioral Research and Testing features the contributions of noted experts describing the application of non-animal methods in a wide variety of research and testing situations, including computer modeling/graphics, protein sequence analysis, behavioral analysis, drug design/testing, cosmetic and household products testing, toxicological testing, clinical ...

United States Congressional Serial Set

United States Congressional Serial Set
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2002
  • Total pages : 212
  • ISBN : 0128136987
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Summary : Download or read online United States Congressional Serial Set written by , published by which was released on 2002. Get United States Congressional Serial Set Books now! Available in PDF, ePub and Kindle....

Alternatives to Laboratory Animals

Alternatives to Laboratory Animals
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2008
  • Total pages : 212
  • ISBN : 0128136987
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Summary : Download or read online Alternatives to Laboratory Animals written by , published by which was released on 2008. Get Alternatives to Laboratory Animals Books now! Available in PDF, ePub and Kindle....

Veterinary and Human Toxicology

Veterinary and Human Toxicology
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1998
  • Total pages : 212
  • ISBN : 0128136987
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Summary : Download or read online Veterinary and Human Toxicology written by , published by which was released on 1998. Get Veterinary and Human Toxicology Books now! Available in PDF, ePub and Kindle....

Departments of Labor and Health and Human Services Education and Related Agencies Appropriations

Departments of Labor  and Health and Human Services  Education  and Related Agencies Appropriations
  • Author : United States. Congress. Senate. Committee on Appropriations
  • Publisher : Unknown
  • Release Date : 2006
  • Total pages : 212
  • ISBN : 0128136987
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Summary : Download or read online Departments of Labor and Health and Human Services Education and Related Agencies Appropriations written by United States. Congress. Senate. Committee on Appropriations, published by which was released on 2006. Get Departments of Labor and Health and Human Services Education and Related Agencies Appropriations Books now! Available in ...