Strategies and Tactics in Organic Synthesis

Written By Michael Harmata
Strategies and Tactics in Organic Synthesis
  • Publsiher : Academic Press
  • Release : 31 December 2012
  • ISBN : 0123865395
  • Pages : 460 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Strategies and Tactics in Organic Synthesis written by Michael Harmata which was release on 31 December 2012, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, this book vividly demonstrates through first hand accounts how synthesis is really done and how by discovering new reactions, creating new designs and building molecules with atom and step economies, the advancement of the science of organic synthesis is providing solutions through function to create a better world. Presents state-of-the-art developments in organic synthesis Provides insight and offers new perspective to problem-solving Written by leading experts in the field

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Michael Harmata
  • Publisher : Academic Press
  • Release Date : 2012-12-31
  • Total pages : 460
  • ISBN : 0123865395
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Summary : A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, this book vividly demonstrates through first hand accounts ...

Strategies and Tactics In Organic Synthesis

Strategies and Tactics In Organic Synthesis
  • Author : Thomas Lindberg
  • Publisher : Elsevier
  • Release Date : 2012-12-02
  • Total pages : 384
  • ISBN : 0123865395
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Summary : Strategies and Tactics in Organic Synthesis presents the chronological development of ideas and experimentation in organic synthesis. This book is organized into 13 chapters that explore the synthetic pathways of various organic compounds. The first four chapters describe the variations in the synthesis of superphane, gibberellic acid, prostaglandin, and alkaloids. The ...

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Michael Harmata
  • Publisher : Academic Press
  • Release Date : 2008-01
  • Total pages : 516
  • ISBN : 0123865395
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Summary : This work provides a forum for investigators to discuss their approach to the science and art of organic. Rather than a simple presentation of data or a second-hand analysis, it provides stories which demonstrate the power of the human endeavour known as organic synthesis and the creativity and tenacity of ...

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Michael Harmata
  • Publisher : Academic Press
  • Release Date : 2004-06-29
  • Total pages : 436
  • ISBN : 0123865395
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Summary : A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the ...

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Michael Harmata
  • Publisher : Elsevier
  • Release Date : 2011-08-09
  • Total pages : 536
  • ISBN : 0123865395
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Summary : A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic. Rather than a simple presentation of data or a second-hand analysis, we are given stories that vividly demonstrate the power ...

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Erik J. Sorensen,David A. Siler,Jeffrey D. Mighion
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-07-29
  • Total pages : 344
  • ISBN : 0123865395
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Summary : This chapter defines risk-taking in organic synthesis as the deliberate pursuit of strategies that do not have near neighbors in the chemical literature. In these ventures into the unknown, chemical behavior can be difficult to predict. The literature of organic chemistry is replete with examples of powerful, bond-forming strategies that ...

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Jason M. Tenenbaum,William J. Morris,Daniel W. Custar,Karl A. Scheidt
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-07-29
  • Total pages : 344
  • ISBN : 0123865395
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Summary : This account describes the convergent synthesis of (−)-okilactomycin. The first-generation approach focused on the assembly of two complex fragments through a Prins reaction of a dioxinone and α-hydroxy aldehyde. While this route was not ultimately successful, a related Maitland–Japp process employing a β-keto ester in place of the dioxinone ...

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Michael F. Greaney,Lei Shi,Naim Nazef
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-07-29
  • Total pages : 344
  • ISBN : 0123865395
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Summary : This chapter describes the synthesis of two related sesquiterpenes, anislactone A and merrilactone A. We initially accessed a tetracyclic oxetane in the merrilactone series using a Paternò–Büchi reaction but found the compound to be too underfunctionalized to advance further. We then developed an approach based on reductive epoxide ...

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Steven L. Castle,Bing Ma
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-07-29
  • Total pages : 344
  • ISBN : 0123865395
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Summary : This account describes the total synthesis of the title compound, an antimitotic bicyclic peptide. A first-generation approach involving right-hand ring formation followed by left-hand ring annulation was unsuccessful but yielded several interesting observations. A revised strategy was devised in which left-hand ring synthesis would precede right-hand macrocycle construction. A suitably ...

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Michel Miesch,Tania Welsch,Vincent Rietsch,Laurence Miesch
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-07-29
  • Total pages : 344
  • ISBN : 0123865395
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Summary : This chapter describes various syntheses of hamigeran B. Different methodologies were developed, and for our part, we achieved a formal synthesis of (±)-hamigeran B involving an intramolecular alkynylogous Mukaiyama aldol reaction promoted by dual Lewis acid activation as a key step. This unexpected reaction was discovered by treating a ketone ...

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Gopal Sirasani,Rodrigo B. Andrade
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-07-29
  • Total pages : 344
  • ISBN : 0123865395
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Summary : Described herein is an account of my laboratory’s entry into the magnificent field of complex alkaloid total synthesis, spanning the development of novel methods for quickly assembling polycyclic frameworks through the total synthesis of various members of the Strychnos alkaloids. A discussion of the prior art related to our ...

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Joseph D. Panarese,Stephen P. Waters
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-07-29
  • Total pages : 344
  • ISBN : 0123865395
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Summary : In 2008, (+)-aspergillide C, a structurally novel marine metabolite bearing a 14-membered macrolactone around a 2,6-dihydropyran core, was isolated from a marine-derived fungus, Aspergillus ostianus. In a biological assay, (+)-aspergillide C displayed promising anticancer activity (LD50=2.0μg/ml) against mouse lymphocytic leukemia cells (L1210). Due to its notable biological activity and ...

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Jenny B. Werness,Wei Zhang,Weiping Tang
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-07-29
  • Total pages : 344
  • ISBN : 0123865395
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Summary : Addition of halogen and nucleophiles to conjugated 1,3-enynes in a 1,4-fashion produces a chiral allene and a stereogenic center. The diastereo- and enantioselectivity of this process are discussed in detail. The 1,4-bromoetherification of 1,3-enynes can be applied to the synthesis of various bromoallene-containing natural products. Our diastereo- and enantioselective total ...

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Thomas James Lindberg,Michael Harmata
  • Publisher : Unknown
  • Release Date : 2008
  • Total pages : 516
  • ISBN : 0123865395
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Summary : Download or read online Strategies and Tactics in Organic Synthesis written by Thomas James Lindberg,Michael Harmata, published by which was released on 2008. Get Strategies and Tactics in Organic Synthesis Books now! Available in PDF, ePub and Kindle....

Strategies and Tactics in Organic Synthesis

Strategies and Tactics in Organic Synthesis
  • Author : Masayuki Inoue,Daisuke Urabe
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-07-29
  • Total pages : 344
  • ISBN : 0123865395
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Summary : In this chapter, we described the asymmetric total synthesis of merrilactone A and resolvin E2 based on the symmetry-driven strategy. The enantio- and diastereoselective transannular aldol reaction of the meso eight-membered diketone led to the efficient total syntheses of both enantiomers of merrilactone A, and the convergent assembly of the ...