RNA Therapeutics

Written By Mouldy Sioud
RNA Therapeutics
  • Publsiher : Humana
  • Release : 23 August 2016
  • ISBN : 9781493961511
  • Pages : 526 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled RNA Therapeutics written by Mouldy Sioud which was release on 23 August 2016, this book published by Humana. Available in PDF, EPUB and Kindle Format. Book excerpt: Central to the synthesis of proteins, the performance of catalysis, and many other physiological processes, the aberrant expression of which can be linked to human diseases including cancers, RNA has proven to be key target for therapeutics as well as a tool for therapy. In RNA Therapeutics: Function, Design, and Delivery, expert contributors from a broad spectrum of scientific backgrounds highlight the roles that messenger RNAs and small RNAs can play in biology and medicine. While covering the five major RNA-based drugs, namely the use of ribozymes to cleave and/or correct mRNA transcript, the use of siRNA for targeted silencing of gene transcripts, the use of aptamers, like short RNA molecules, for neutralizing the protein functions, the use mRNA-transfected DCs to activate immune system against tumor cells, as well as the use of RNA to reprogram T and/or DC cell function, this extensive volume brings together the fields of coding (mRNA) and non-coding RNA such as ribozymes, RNAse P, siRNAs, and miRNAs into one convenient source. Written in the highly successful Methods in Molecular BiologyTM series format, the cutting-edge protocol chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and practical tips on troubleshooting and avoiding known pitfalls. Also, the book contains several excellent reviews for teaching purposes. Authoritative and comprehensive, RNA Therapeutics: Function, Design, and Delivery provides key models and tools which will assist researchers in increasing our understanding of RNA functions, modifications, and their involvement in diseases in order to lead to the design of vital new RNA-based therapeutics.

RNA Therapeutics

RNA Therapeutics
  • Author : Mouldy Sioud
  • Publisher : Humana
  • Release Date : 2016-08-23
  • Total pages : 526
  • ISBN : 9781493961511
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Summary : Central to the synthesis of proteins, the performance of catalysis, and many other physiological processes, the aberrant expression of which can be linked to human diseases including cancers, RNA has proven to be key target for therapeutics as well as a tool for therapy. In RNA Therapeutics: Function, Design, and ...

RNA Therapeutics

RNA Therapeutics
  • Author : Amanda L. Garner
  • Publisher : Springer
  • Release Date : 2017-09-26
  • Total pages : 259
  • ISBN : 9781493961511
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Summary : Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the ...

RNA Therapeutics

RNA Therapeutics
  • Author : Paloma H. Giangrande,Vittorio Defranciscis,John J. Rossi
  • Publisher : Academic Press
  • Release Date : 2021-06-15
  • Total pages : 512
  • ISBN : 9781493961511
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Summary : RNA Therapeutics: The Evolving Landscape of RNA Therapeutics provides a comprehensive overview of RNA therapeutic modalities, from bench-to-bedside, with emphasis on the increasingly impactful areas of gene therapy, oligonucleotide therapeutics, gene editing, and delivery. International leaders in the field examine RNA-based therapeutics tools that have been developed to-date to modulate ...

Entering the RNA Wonderland Opportunities and Challenges for RNA Therapeutics in the Cardiovascular System

Entering the RNA Wonderland  Opportunities and Challenges for RNA Therapeutics in the Cardiovascular System
  • Author : Anna Zampetaki,Lars Maegdefessel
  • Publisher : Frontiers Media SA
  • Release Date : 2020-07-22
  • Total pages : 212
  • ISBN : 9781493961511
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Summary : Download or read online Entering the RNA Wonderland Opportunities and Challenges for RNA Therapeutics in the Cardiovascular System written by Anna Zampetaki,Lars Maegdefessel, published by Frontiers Media SA which was released on 2020-07-22. Get Entering the RNA Wonderland Opportunities and Challenges for RNA Therapeutics in the Cardiovascular System ...

RNA Nanotechnology and Therapeutics

RNA Nanotechnology and Therapeutics
  • Author : Peixuan Guo,Farzin Haque
  • Publisher : CRC Press
  • Release Date : 2013-07-09
  • Total pages : 611
  • ISBN : 9781493961511
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Summary : Interest in RNA nanotechnology has increased in recent years as recognition of its potential for applications in nanomedicine has grown. Edited by the world's foremost experts in nanomedicine, this comprehensive, state-of-the-art reference details the latest research developments and challenges in the biophysical and single molecule approaches in R...

RNA Interference from Biology to Therapeutics

RNA Interference from Biology to Therapeutics
  • Author : Kenneth A. Howard
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-10-19
  • Total pages : 340
  • ISBN : 9781493961511
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Summary : The enormous potential of siRNA as a therapeutic has led to an explosion of interest from the scientific community. There has been intense interest from Big Pharma to capitalise on this new technology but the fact remains that delivery is a key determinant in realizing the full clinical potential of ...

AGO Driven Non Coding RNAs

AGO Driven Non Coding RNAs
  • Author : Bibekanand Mallick
  • Publisher : Academic Press
  • Release Date : 2019-01-20
  • Total pages : 387
  • ISBN : 9781493961511
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Summary : The ‘RNA world’ hypothesis that proposed RNA molecules as the first form of genetic material was put forwarded in the late 1980s but got impetus only recently when high-throughput sequencing technologies began unearthing new types of non-coding RNA (ncRNA) transcripts in higher eukaryotes. Till then, research on ncRNAs were primarily ...

Design and Application of RNA Therapeutics for Splice Site Mutations

Design and Application of RNA Therapeutics for Splice Site Mutations
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2015
  • Total pages : 67
  • ISBN : 9781493961511
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Summary : Download or read online Design and Application of RNA Therapeutics for Splice Site Mutations written by , published by which was released on 2015. Get Design and Application of RNA Therapeutics for Splice Site Mutations Books now! Available in PDF, ePub and Kindle....

RNA Delivery Function for Anticancer Therapeutics

RNA Delivery Function for Anticancer Therapeutics
  • Author : Loutfy H. Madkour
  • Publisher : CRC Press
  • Release Date : 2022-01-26
  • Total pages : 424
  • ISBN : 9781493961511
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Summary : This book presents an overview of the current status of translating the RNAi cancer therapeutics in the clinic, a brief description of the biological barriers in drug delivery, and the roles of imaging in aspects of administration route, systemic circulation, and cellular barriers for the clinical translation of RNAi cancer ...

Therapeutic RNA Nanotechnology

Therapeutic RNA Nanotechnology
  • Author : Kirill A. Afonin,Morgan Chandler
  • Publisher : CRC Press
  • Release Date : 2021-07-22
  • Total pages : 1228
  • ISBN : 9781493961511
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Summary : This collection of research articles and reviews covers the latest work in the design, delivery, dynamic abilities, and immune stimulation of RNA nanoparticles which have driven the utilization of their immunomodulatory properties. The unknown immune properties of nucleic acid nanoparticles have been a major hurdle in their adaptation until the ...

Long Non Coding RNA

Long Non Coding RNA
  • Author : Syed Mudasir Ahmad,Nazir Ahmad Ganai
  • Publisher : Cambridge Scholars Publishing
  • Release Date : 2020-09-03
  • Total pages : 201
  • ISBN : 9781493961511
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Summary : Long non-coding RNAs (LncRNAs) were originally regarded as “noise” in the genome due to their lack of protein-encoding capacity. However, their roles are now understood to cover various biological functions like gene regulation, cell proliferation, survival, differentiation, and chromatin remodeling. As an emerging group of non-coding RNA molecules, LncRNAs are ...

From Nucleic Acids Sequences to Molecular Medicine

From Nucleic Acids Sequences to Molecular Medicine
  • Author : Volker A. Erdmann,Jan Barciszewski
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-06-13
  • Total pages : 654
  • ISBN : 9781493961511
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Summary : Despite a half century of structural, biophysical and biochemical investigations of ribonucleic acids, they are still mysterious. RNAs stand at fertile crossroads of disciplines, integrating concepts from genomics, proteomics, dynamics as well as biochemistry and molecular biology. From 20 years it is clear, that genetic regulation of eukaryotic organisms has been ...

Nucleic Acid Therapeutics in Cancer

Nucleic Acid Therapeutics in Cancer
  • Author : Alan M. Gewirtz
  • Publisher : Springer Science & Business Media
  • Release Date : 2004-03-25
  • Total pages : 221
  • ISBN : 9781493961511
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Summary : A cutting-edge review of the important issues underlying the therapeutic use of nucleic acid-mediated gene silencing. Topics range from basic methodology and delivery to targeting and clinical targets. The authors thoroughly explain the latest developments in RNA biology, as well as the underpinnings of RNA interference, oligodeoxynucleotide delivery into cells, ...

Gold Nanoparticle Enhancements in Electroporation Mediated DNA and RNA Therapeutics

Gold Nanoparticle Enhancements in Electroporation Mediated DNA and RNA Therapeutics
  • Author : Shuyan Huang
  • Publisher : Unknown
  • Release Date : 2015
  • Total pages : 224
  • ISBN : 9781493961511
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Summary : Download or read online Gold Nanoparticle Enhancements in Electroporation Mediated DNA and RNA Therapeutics written by Shuyan Huang, published by which was released on 2015. Get Gold Nanoparticle Enhancements in Electroporation Mediated DNA and RNA Therapeutics Books now! Available in PDF, ePub and Kindle....

RNA Delivery Function for Anticancer Therapeutics

RNA Delivery Function for Anticancer Therapeutics
  • Author : Loutfy H. Madkour
  • Publisher : CRC Press
  • Release Date : 2022-01-26
  • Total pages : 424
  • ISBN : 9781493961511
GET BOOK

Summary : This book presents an overview of the current status of translating the RNAi cancer therapeutics in the clinic, a brief description of the biological barriers in drug delivery, and the roles of imaging in aspects of administration route, systemic circulation, and cellular barriers for the clinical translation of RNAi cancer ...