Quantitative Systems Pharmacology

Written By Davide Manca
Quantitative Systems Pharmacology
  • Publsiher : Elsevier
  • Release : 18 July 2018
  • ISBN : 0444639675
  • Pages : 418 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Quantitative Systems Pharmacology written by Davide Manca which was release on 18 July 2018, this book published by Elsevier. Available in PDF, EPUB and Kindle Format. Book excerpt: Quantitative Systems Pharmacology: Models and Model-Based Systems with Applications, Volume 42, provides a quantitative approach to problem-solving that is targeted to engineers. The book gathers the contributions of doctors, pharmacists, biologists, and chemists who give key information on the elements needed to model a complex machine like the human body. It presents information on diagnoses, administration and release of therapeutics, distribution metabolism and excretion of drugs, compartmental pharmacokinetics, physiologically-based pharmacokinetics, pharmacodynamics, identifiability of models, numerical methods for models identification, design of experiments, in vitro and in vivo models, and more. As the pharma community is progressively acknowledging that a quantitative and systematic approach to drug administration, release, pharmacokinetics and pharmacodynamics is highly recommended to understand the mechanisms and effects of drugs, this book is a timely resource. Outlines a model-based approach (based on Process Systems Engineering-OSE and Computer Aided Process Engineering-CAPE) in quantitative pharmacology Explains how therapeutics work in the human body and how anatomy and physiology influences drug efficacy Discusses how drugs are driven to specific targets using nanoparticles Offers insight into how in vitro and in vivo experiments help understand the drug mechanism of action and optimize their performance Includes case studies showing the positive outcome of these methods in personalized therapies, therapeutic drug monitoring, clinical trials analysis and drug formulation

Quantitative Systems Pharmacology

Quantitative Systems Pharmacology
  • Author : Davide Manca
  • Publisher : Elsevier
  • Release Date : 2018-07-18
  • Total pages : 418
  • ISBN : 0444639675
GET BOOK

Summary : Quantitative Systems Pharmacology: Models and Model-Based Systems with Applications, Volume 42, provides a quantitative approach to problem-solving that is targeted to engineers. The book gathers the contributions of doctors, pharmacists, biologists, and chemists who give key information on the elements needed to model a complex machine like the human body. It ...

The Emerging Discipline of Quantitative Systems Pharmacology

The Emerging Discipline of Quantitative Systems Pharmacology
  • Author : Tarek A. Leil,Sergey Ermakov
  • Publisher : Unknown
  • Release Date : 2015-09-07
  • Total pages : 212
  • ISBN : 0444639675
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Summary : In 2011, the National Institutes of Health (NIH), in collaboration with leaders from the pharmaceutical industry and the academic community, published a white paper describing the emerging discipline of Quantitative Systems Pharmacology (QSP), and recommended the establishment of NIH-supported interdisciplinary research and training programs for QSP. QSP is still in its ...

The Emerging Discipline of Quantitative Systems Pharmacology

The Emerging Discipline of Quantitative Systems Pharmacology
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2021-06-25
  • Total pages : 212
  • ISBN : 0444639675
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Summary : Download or read online The Emerging Discipline of Quantitative Systems Pharmacology written by , published by which was released on . Get The Emerging Discipline of Quantitative Systems Pharmacology Books now! Available in PDF, ePub and Kindle....

Biochemical Thermodynamic Modelling of Cellular Bioenergetics

Biochemical Thermodynamic Modelling of Cellular Bioenergetics
  • Author : R. A. Kelly
  • Publisher : Unknown
  • Release Date : 2018
  • Total pages : 212
  • ISBN : 0444639675
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Summary : Download or read online Biochemical Thermodynamic Modelling of Cellular Bioenergetics written by R. A. Kelly, published by which was released on 2018. Get Biochemical Thermodynamic Modelling of Cellular Bioenergetics Books now! Available in PDF, ePub and Kindle....

Abstracts ASCPT 2015 Annual Meeting Quantitative Systems Pharmacology Multiscale Model Based Drug Development Through Integrating Systems Biology and Pharmacometrics Pre Conference

Abstracts ASCPT 2015 Annual Meeting   Quantitative Systems Pharmacology  Multiscale Model Based Drug Development Through Integrating Systems Biology and Pharmacometrics Pre Conference
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2015
  • Total pages : 116
  • ISBN : 0444639675
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Summary : Download or read online Abstracts ASCPT 2015 Annual Meeting Quantitative Systems Pharmacology Multiscale Model Based Drug Development Through Integrating Systems Biology and Pharmacometrics Pre Conference written by , published by which was released on 2015. Get Abstracts ASCPT 2015 Annual Meeting Quantitative Systems Pharmacology Multiscale Model Based Drug Development Through Integrating Systems Biology and ...

Abstracts ASCPT 2013 Annual Meeting Quantitative Systems Pharmacology an Integrating Framework for Translational Medicine

Abstracts ASCPT 2013 Annual Meeting   Quantitative Systems Pharmacology  an Integrating Framework for Translational Medicine
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2013
  • Total pages : 137
  • ISBN : 0444639675
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Summary : Download or read online Abstracts ASCPT 2013 Annual Meeting Quantitative Systems Pharmacology an Integrating Framework for Translational Medicine written by , published by which was released on 2013. Get Abstracts ASCPT 2013 Annual Meeting Quantitative Systems Pharmacology an Integrating Framework for Translational Medicine Books now! Available in PDF, ePub and Kindle....

Systems Pharmacology and Pharmacodynamics

Systems Pharmacology and Pharmacodynamics
  • Author : Donald E. Mager,Holly H.C. Kimko
  • Publisher : Springer
  • Release Date : 2016-11-29
  • Total pages : 511
  • ISBN : 0444639675
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Summary : While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from ...

Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune Mediated Inflammatory Diseases

Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune Mediated Inflammatory Diseases
  • Author : Honghui Zhou,Diane R. Mould
  • Publisher : Wiley
  • Release Date : 2019-03-19
  • Total pages : 496
  • ISBN : 0444639675
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Summary : Thorough Overview Identifies and Addresses Critical Gaps in the Treatment of Several Chronic Diseases With increasing numbers of patients suffering from Immune-Mediated Inflammatory Diseases (IMIDs), and with the increasing reliance on biopharmaceuticals to treat them, it is imperative that researchers and medical practitioners have a thorough understanding of the absorption, ...

Computational Systems Pharmacology and Toxicology

Computational Systems Pharmacology and Toxicology
  • Author : Rudy J Richardson,Dale E Johnson
  • Publisher : Royal Society of Chemistry
  • Release Date : 2017-03-01
  • Total pages : 332
  • ISBN : 0444639675
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Summary : The network approaches of systems pharmacology and toxicology serve as early predictors of the most relevant screening approach to pursue both in drug discovery and development and ecotoxicological assessments. Computational approaches have the potential to improve toxicological experimental design, enable more rapid drug efficacy and safety testing and also reduce ...

Quantitative Methods in System Based Drug Discovery

Quantitative Methods in System Based Drug Discovery
  • Author : Yuzhen Luo
  • Publisher : Unknown
  • Release Date : 2016
  • Total pages : 212
  • ISBN : 0444639675
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Summary : Modern pharmaceutical industries have faced significant challenges to deliver safe and effective medicines because of significant toxicity and severe side effects of discovered drugs. On the other hand, recent developments and advances in system-based pharmacology aim to address these challenges. In this chapter, we provide an overview of quantitative methods ...

Proceedings of the First International Pharmacological Meeting Abstracts

Proceedings of the First International Pharmacological Meeting  Abstracts
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1962
  • Total pages : 212
  • ISBN : 0444639675
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Summary : Download or read online Proceedings of the First International Pharmacological Meeting Abstracts written by , published by which was released on 1962. Get Proceedings of the First International Pharmacological Meeting Abstracts Books now! Available in PDF, ePub and Kindle....

Improving the Use of G CSF During Chemotherapy Using Physiological Mathematical Modelling

Improving the Use of G CSF During Chemotherapy Using Physiological Mathematical Modelling
  • Author : Morgan Craig
  • Publisher : Unknown
  • Release Date : 2015
  • Total pages : 212
  • ISBN : 0444639675
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Summary : Dose-limitation or interruption of chemotherapeutic treatment is most often prompted by a decrease in circulating neutrophils, the most abundant white blood cell in the human body. Myelosuppression, or a reduction in absolute neutrophil counts (ANCs) by anti-cancer treatments, is precipitated by the nonspecific killing effect of chemotherapeutic drugs which have ...

Computational Neurology and Psychiatry

Computational Neurology and Psychiatry
  • Author : Péter Érdi,Basabdatta Sen Bhattacharya,Amy L. Cochran
  • Publisher : Springer
  • Release Date : 2017-01-25
  • Total pages : 448
  • ISBN : 0444639675
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Summary : This book presents the latest research in computational methods for modeling and simulating brain disorders. In particular, it shows how mathematical models can be used to study the relationship between a given disorder and the specific brain structure associated with that disorder. It also describes the emerging field of computational ...

Bioinformatics and Biomedical Engineering

Bioinformatics and Biomedical Engineering
  • Author : Francisco Ortuño,Ignacio Rojas
  • Publisher : Springer
  • Release Date : 2015-04-01
  • Total pages : 674
  • ISBN : 0444639675
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Summary : The two volume set LNCS 9043 and 9044 constitutes the refereed proceedings of the Third International Conference on Bioinformatics and Biomedical Engineering, IWBBIO 2015, held in Granada, Spain in April 2015. The 134 papers presented were carefully reviewed and selected from 268 submissions. The scope of the conference spans the following areas: bioinformatics for healthcare and ...

Modeling Evolution of Heterogeneous Populations

Modeling Evolution of Heterogeneous Populations
  • Author : Irina Kareva,Georgy Karev
  • Publisher : Academic Press
  • Release Date : 2019-10-16
  • Total pages : 354
  • ISBN : 0444639675
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Summary : Modeling Evolution of Heterogeneous Populations: Theory and Applications describes, develops and provides applications of a method that allows incorporating population heterogeneity into systems of ordinary and discrete differential equations without significantly increasing system dimensionality. The method additionally allows making use of results of bifurcation analysis performed on simplified homogeneous systems, ...