Pyrazole Based Drug Discovery

Written By Nachiket S. Dighe
Pyrazole Based Drug Discovery
  • Publsiher : Elsevier
  • Release : 15 June 2021
  • ISBN : 9780128241400
  • Pages : 370 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Pyrazole Based Drug Discovery written by Nachiket S. Dighe which was release on 15 June 2021, this book published by Elsevier. Available in PDF, EPUB and Kindle Format. Book excerpt: Pyrazole-Based Drug Discovery outlines the complexities of the pyrazole scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Designed as a guide for both experts and students working in this and related areas, this volume will facilitate the continued design and development of novel pharmaceuticals based on pyrazole and its derivatives. Heterocyclic compounds are of central importance to medicinal chemistry, as demonstrated by the high percentage of marketable drugs that feature heterocyclic fragments in their structures. As starting points for drug discovery they offer a broad range of attractive properties, and a detailed understanding of the particular characteristics of each is of great benefit to researchers. Pyrazole is a novel heterocycle with anti-fungal, antimicrobial, anti-tubercular, and antipsychotic pharmacological activities, proving to be a promising agent for medicinal chemists to synthesize various new chemical entities with desired biological activities. This book is ideal for researchers working in organic and medicinal chemistry both in academia and industry. Explores this extremely important heterocycle in a high level of detail Describes synthesis methods for current drugs based on pyrazole scaffolds Gives drug designers all the key knowledge required to develop new drugs utilizing pyrazole Provides pharmacologists a solid overview of the chemical background of existing pyrazole-based drugs

Pyrazole Based Drug Discovery

Pyrazole Based Drug Discovery
  • Author : Nachiket S. Dighe,Ravindra B. Laware
  • Publisher : Elsevier
  • Release Date : 2021-06-15
  • Total pages : 370
  • ISBN : 9780128241400
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Summary : Pyrazole-Based Drug Discovery outlines the complexities of the pyrazole scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Designed as a guide for both experts and students working in this and related areas, this volume will facilitate the continued design and development of ...

Pyrazole

Pyrazole
  • Author : Dilipkumar Pal
  • Publisher : Nova Science Publishers
  • Release Date : 2020
  • Total pages : 563
  • ISBN : 9780128241400
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Summary : "This book has comprehensively reviewed the latest information on pyrazoles, their preparations and uses. It provides extended ideas on pyrazole and its derivatives including their synthesis, chemistry, structure activity relationship (SAR) and therapeutic applications. The health promoting properties of these pyrazoles are discussed in this book with different therapeutic applications ...

Heterocyclic Chemistry in Drug Discovery

Heterocyclic Chemistry in Drug Discovery
  • Author : Jie Jack Li
  • Publisher : John Wiley & Sons
  • Release Date : 2013-04-26
  • Total pages : 720
  • ISBN : 9780128241400
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Summary : Enables researchers to fully realize the potential to discover new pharmaceuticals among heterocyclic compounds Integrating heterocyclic chemistry and drug discovery, this innovative text enables readers to understand how and why these two fields go hand in hand in the effective practice of medicinal chemistry. Contributions from international leaders in the ...

Structure based Drug Discovery

Structure based Drug Discovery
  • Author : Harren Jhoti,Andrew R. Leach
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-05-24
  • Total pages : 250
  • ISBN : 9780128241400
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Summary : This book describes some of the most exciting developments for the discovery of new drugs, such as Fragment-based methods. It contains the latest developments in technologies that can be used to obtain the 3-D structures. This book includes experimental approaches using X-ray crystallography and NMR for Fragment-based screening as well ...

Applications of Heterocycles in the Design of Drugs and Agricultural Products

Applications of Heterocycles in the Design of Drugs and Agricultural Products
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2021-06-18
  • Total pages : 330
  • ISBN : 9780128241400
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Summary : Applications of Heterocycles in the Design of Drugs and Agricultural Products, Volume 134 in the Advances in Heterocyclic Chemistry series represents the most definitive series in the field - one of great importance to organic chemists, polymer chemists, and many biological scientists. Chapters in this updated volume cover Hydroxy azoles as ...

Drug Discovery for Leishmaniasis

Drug Discovery for Leishmaniasis
  • Author : Carmen Gil,Luis Rivas
  • Publisher : Royal Society of Chemistry
  • Release Date : 2017-10-26
  • Total pages : 402
  • ISBN : 9780128241400
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Summary : For human health, leishmaniasis is among the most important protozoan diseases, superseded only by malaria. Globally, 10 to 12 million people are infected with 1.5 million new cases every year. The development of cheaper new drugs is urgently needed for this neglected disease that is developing resistance to current treatments. Chemotherapy remains the ...

Drug Discovery and Drug Development

Drug Discovery and Drug Development
  • Author : Madhu Dikshit
  • Publisher : Springer Nature
  • Release Date : 2021-08-01
  • Total pages : 212
  • ISBN : 9780128241400
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Summary : Download or read online Drug Discovery and Drug Development written by Madhu Dikshit, published by Springer Nature which was released on . Get Drug Discovery and Drug Development Books now! Available in PDF, ePub and Kindle....

Privileged Structures in Drug Discovery

Privileged Structures in Drug Discovery
  • Author : Larry Yet
  • Publisher : John Wiley & Sons
  • Release Date : 2018-03-07
  • Total pages : 560
  • ISBN : 9780128241400
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Summary : A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that ...

Scope of Selective Heterocycles from Organic and Pharmaceutical Perspective

Scope of Selective Heterocycles from Organic and Pharmaceutical Perspective
  • Author : Ravi Varala
  • Publisher : BoD – Books on Demand
  • Release Date : 2016-06-30
  • Total pages : 168
  • ISBN : 9780128241400
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Summary : Scope of Selective Heterocycles from Organic and Pharmaceutical Perspective is a compilation of bioactive-chosen heterocyclic scaffolds intended for postgraduates, research scholars, pharmaceutical scientists, and others interested in an appreciation of the title subject. It is an edited book and is not comprehensive as well in the mentioned field. Few synthetic ...

Synthetic Methods in Drug Discovery

Synthetic Methods in Drug Discovery
  • Author : David C. Blakemore,Paul M. Doyle,Yvette M. Fobian
  • Publisher : Royal Society of Chemistry
  • Release Date : 2016-05-30
  • Total pages : 474
  • ISBN : 9780128241400
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Summary : The number of available synthetic methods can be overwhelming. In order to create novel motifs and templates which confer new and potentially valuable drug-like properties, it is important to know which synthetic methodologies will give the best results. Similarly, which methodologies are used to progress potential drug candidates from leads ...

Privileged Scaffolds in Medicinal Chemistry

Privileged Scaffolds in Medicinal Chemistry
  • Author : Stefan Bräse
  • Publisher : Royal Society of Chemistry
  • Release Date : 2015-11-20
  • Total pages : 468
  • ISBN : 9780128241400
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Summary : One strategy to expedite the discovery of new drugs, a process that is somewhat slow and serendipitous, is the identification and use of privileged scaffolds. This book covers the history of the discovery and use of privileged scaffolds and addresses the various classes of these important molecular fragments. The first ...

Analogue based Drug Discovery III

Analogue based Drug Discovery III
  • Author : János Fischer,C. Robin Ganellin,David P. Rotella
  • Publisher : John Wiley & Sons
  • Release Date : 2012-10-15
  • Total pages : 404
  • ISBN : 9780128241400
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Summary : Most drugs are analogue drugs. There are no general rules how a new drug can be discovered, nevertheless, there are some observations which help to find a new drug, and also an individual story of a drug discovery can initiate and help new discoveries. Volume III is a continuation of ...

Chemical Sciences in Early Drug Discovery

Chemical Sciences in Early Drug Discovery
  • Author : Pierfausto Seneci
  • Publisher : Elsevier
  • Release Date : 2018-06-05
  • Total pages : 194
  • ISBN : 9780128241400
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Summary : Chemical Sciences in Early Drug Discovery: Medicinal Chemistry 2.0 describes how new technologies and approaches can be used to improve the probability of success in fulfilling the perennial goal of finding and developing new drugs. Drawing on the author's extensive experience consulting and teaching in medicinal chemistry, the book outlines ways ...

Pharmaceutical Sciences Breakthroughs in Research and Practice

Pharmaceutical Sciences  Breakthroughs in Research and Practice
  • Author : Management Association, Information Resources
  • Publisher : IGI Global
  • Release Date : 2016-12-28
  • Total pages : 1584
  • ISBN : 9780128241400
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Summary : The delivery of optimal pharmaceutical services to patients is a pivotal concern in the healthcare field. By examining current trends and techniques in the industry, processes can be maintained and improved. Pharmaceutical Sciences: Breakthroughs in Research and Practice provides comprehensive coverage of the latest innovations and advancements for pharmaceutical applications. ...

Drug Discovery for Psychiatric Disorders

Drug Discovery for Psychiatric Disorders
  • Author : Zoran Rankovic,Richard Hargreaves,Matilda Bingham
  • Publisher : Royal Society of Chemistry
  • Release Date : 2012-10-08
  • Total pages : 678
  • ISBN : 9780128241400
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Summary : The discovery and development of effective medicines for the treatment of psychiatric disorders such as schizophrenia and depression has been heralded as one of the great medical achievements of the past century. Indeed, the profound impact of these medicines on our understanding of the pathophysiology underlying these diseases, the treatment ...