Proteolytic Signaling in Health and Disease

Written By Andre Zelanis
Proteolytic Signaling in Health and Disease
  • Publsiher : Academic Press
  • Release : 13 October 2021
  • ISBN : 0323856977
  • Pages : 308 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Proteolytic Signaling in Health and Disease written by Andre Zelanis which was release on 13 October 2021, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: In recent years, powered by evolving technologies and experimental design, studies have better illuminated the regulating role of proteolytic enzymes across human development and pathologies. Proteolytic Signaling in Health and Disease provides an in-depth discussion of fundamental physiological and developmental processes regulated by proteases, from protein turnover and autophagy to antigen processing and presentation and major histocompatibility complex (MHC) molecules. Moving on from basic biology, international chapter authors examine a range of pathological conditions associated with proteolysis, including inflammation, wound healing, and cancer. Later chapters discuss the newly discovered network of connected events among proteases (and their inhibitors), the so-called ‘protease web’, and how best to study it. This book also empowers new research with up-to-date analytical methods and step-by-step protocols for studying proteolytic signaling events. Examines biological events triggered by proteolytic enzyme activity across human development and pathologies Discusses the role of proteolytic signaling in inflammation, wound healing, and cancer, among other disease types Features methods and protocols supporting further study of proteolytic signaling events Includes chapter contributions from international leaders in the field

Proteolytic Signaling in Health and Disease

Proteolytic Signaling in Health and Disease
  • Author : Andre Zelanis
  • Publisher : Academic Press
  • Release Date : 2021-10-13
  • Total pages : 308
  • ISBN : 0323856977
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Summary : In recent years, powered by evolving technologies and experimental design, studies have better illuminated the regulating role of proteolytic enzymes across human development and pathologies. Proteolytic Signaling in Health and Disease provides an in-depth discussion of fundamental physiological and developmental processes regulated by proteases, from protein turnover and autophagy to ...

Proteases in Health and Disease

Proteases in Health and Disease
  • Author : Sajal Chakraborti,Naranjan S. Dhalla
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-12-04
  • Total pages : 403
  • ISBN : 0323856977
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Summary : In view of rapidly growing research in the deregulation of proteases and their impact in human health and diseases, this book will highlight existing and emerging research in this exciting area. In-depth critical state-of-the-art reviews will be written by established investigators on proteases dysfunctions associated with pathogenesis of different diseases ...

Proteases in Health and Disease

Proteases in Health and Disease
  • Author : Enrico Di Cera
  • Publisher : Academic Press
  • Release Date : 2011-03-07
  • Total pages : 328
  • ISBN : 0323856977
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Summary : Proteases occur naturally in all organisms. They are enzymes that are involved in many physiological reactions such as digestion of food and blood clotting. This volume reviews their role in health and disease and presents the latest research and developments. * Discusses new discoveries, approaches, and ideas * Contributions from leading scholars ...

Matrix Proteases in Health and Disease

Matrix Proteases in Health and Disease
  • Author : Niels Behrendt
  • Publisher : John Wiley & Sons
  • Release Date : 2012-07-10
  • Total pages : 416
  • ISBN : 0323856977
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Summary : Presenting a comprehensive overview of the multifaceted field of proteases in the extracellular matrix environment, this reference focuses on the recently elucidated functions of complex proteolytic systems in physiological and pathological tissue remodeling. The proteases treated include both serine proteases such as plasminogen activators and TTSPs, metalloproteases such as MMPs ...

Protein Degradation in Health and Disease

Protein Degradation in Health and Disease
  • Author : Michèle Reboud-Ravaux
  • Publisher : Springer Science & Business Media
  • Release Date : 2002
  • Total pages : 130
  • ISBN : 0323856977
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Summary : Protein degradation has been identified as a major mechanism for the regulation of cellular functions. Not surprisingly, its deregulation is implied in almost any pathological condition. This book describes how aged proteins are eliminated during cell metabolism, how cell proliferation is regulated by protein degradation and how its deregulation can ...

Role of Proteases in Cellular Dysfunction

Role of Proteases in Cellular Dysfunction
  • Author : Naranjan S. Dhalla,Sajal Chakraborti
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-11-22
  • Total pages : 462
  • ISBN : 0323856977
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Summary : It is now well known that proteases are found everywhere, in viruses and bacteria as well as in all human, animal and plant cells, and play a role in a variety of biological functions ranging from digestion, fertilization, development to senescence and death. Under physiological conditions the ability of proteases ...

Post Translational Modifications in Health and Disease

Post Translational Modifications in Health and Disease
  • Author : Cecilio J. Vidal
  • Publisher : Springer
  • Release Date : 2012-12-01
  • Total pages : 490
  • ISBN : 0323856977
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Summary : Post-translational modifications serve many different purposes in several cellular processes such as gene expression, protein folding and transport to appropriate cell compartment, protein-lipid and protein-protein interactions, enzyme regulation, signal transduction, cell proliferation and differentiation, protein stability, recycling and degradation. Although several-hundred different modifications are known, the significance of many of ...

Post Translational Modifications in Health and Disease

Post Translational Modifications in Health and Disease
  • Author : Cecilio J. Vidal
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-10-13
  • Total pages : 490
  • ISBN : 0323856977
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Summary : Post-translational modifications serve many different purposes in several cellular processes such as gene expression, protein folding and transport to appropriate cell compartment, protein-lipid and protein-protein interactions, enzyme regulation, signal transduction, cell proliferation and differentiation, protein stability, recycling and degradation. Although several-hundred different modifications are known, the significance of many of ...

Extracellular Matrix Pathobiology and Signaling

Extracellular Matrix  Pathobiology and Signaling
  • Author : Nikos Karamanos
  • Publisher : Walter de Gruyter
  • Release Date : 2012-08-31
  • Total pages : 938
  • ISBN : 0323856977
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Summary : Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell migration, adhesion and signaling. This comprehensive handbook of the extracellular matrix is organized into seven thematic sections, giving an ...

Neuronal Chloride Transporters in Health and Disease

Neuronal Chloride Transporters in Health and Disease
  • Author : Xin Tang
  • Publisher : Academic Press
  • Release Date : 2020-06-19
  • Total pages : 766
  • ISBN : 0323856977
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Summary : In the past several years, there has been an exciting body of new research that links impairments in the expression or function of neuronal chloride transporters to a growing number of diseases spanning from autism to brain aging. This book introduces the core concepts and highlights the recent advances in ...

NF kB in Health and Disease

NF kB in Health and Disease
  • Author : Michael Karin
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-04-26
  • Total pages : 268
  • ISBN : 0323856977
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Summary : Nearly 25 years of intensive research have uncovered many diverse functions for the dimeric transcription factor known as NF-kappaB (nuclear factor-kappaB). NF-kappaB affects most aspects of cellular physiology—from immunity and inflammation to apoptosis, cell survival, growth, and proliferation...

Regulation of Platelet Receptors in Health and Disease

Regulation of Platelet Receptors in Health and Disease
  • Author : Jianlin Qiao
  • Publisher : Unknown
  • Release Date : 2012
  • Total pages : 344
  • ISBN : 0323856977
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Summary : Platelet-specific receptors glycoprotein (GP)VI that binds collagen, and GPIb[alpha], a subunit of GPIb-IX-V complex that binds von Willebrand factor (VWF), initiate platelet adhesion, activation and aggregation in response to exposed collagen/VWF or elevated fluid-shear stress in haemostasis or arterial thrombosis. The overall hypothesis underlying studies in this ...

Adhesion G Protein coupled Receptors

Adhesion G Protein coupled Receptors
  • Author : Tobias Langenhan,Torsten Schöneberg
  • Publisher : Springer
  • Release Date : 2016-11-09
  • Total pages : 403
  • ISBN : 0323856977
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Summary : Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them ...

Autophagy in Health and Disease

Autophagy in Health and Disease
  • Author : Beverly Rothermel,Abhinav Diwan
  • Publisher : Elsevier
  • Release Date : 2021-09-22
  • Total pages : 454
  • ISBN : 0323856977
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Summary : Autophagy in Health and Disease, Second Edition provides a comprehensive overview of the process of autophagy and its impact on human physiology and pathophysiology. It expands on the scope of the first edition by covering a wider range of cell types, developmental processes, and organ systems. The second edition is ...

Ubiquitination in Health and Diseases

Ubiquitination in Health and Diseases
  • Author : Tomoaki Ishigami
  • Publisher : MDPI
  • Release Date : 2021-05-18
  • Total pages : 292
  • ISBN : 0323856977
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Summary : Ubiquitination is a biological process mediated by ubiquitin itself, the E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme, E3 ubiquitin ligase, and deubiquitinating enzyme, respectively. Currently, these multiple biological steps are revealed to participate in various life phenomena, such as cell proliferation, regulation of cell surface proteins expression, and mitochondrial function, which ...