Principles of Asymmetric Synthesis

Written By Robert E. Gawley
Principles of Asymmetric Synthesis
  • Publsiher : Elsevier
  • Release : 17 June 2021
  • ISBN : 0080448607
  • Pages : 555 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Principles of Asymmetric Synthesis written by Robert E. Gawley which was release on 17 June 2021, this book published by Elsevier. Available in PDF, EPUB and Kindle Format. Book excerpt: The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance to the topics under discussion. The study of stereoselectivity has evolved from issues of diastereoselectivity, through auxiliary-based methods for the synthesis of enantiomerically pure compounds (diastereoselectivity followed by separation and auxiliary cleavage), to asymmetric catalysis. In the latter instance, enantiomers (not diastereomers) are the products, and highly selective reactions and modern purification techniques allow preparation - in a single step - of chiral substances in 99% ee for many reaction types. After an explanation of the basic physical-organic principles of stereoselectivity, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on "Analytical Methods" provides a critical overview of the most common methods for analysis of stereoisomers. The authors then follow the 'tried-and-true' format of grouping the material by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions (enolate alkylations, organometal additions to carbonyls, aldol and Michael reactions, and cycloadditions and rearrangements), one chapter on reductions and hydroborations (carbon-hydrogen bond forming reactions), and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). Leading references are provided to natural product synthesis that have been accomplished using a given reaction as a key step. In addition to tables of examples that show high selectivity, a transition state analysis is presented to explain - to the current level of understanding - the stereoselectivity of each reaction. In one case (Cram's rule) the evolution of the current theory is detailed from its first tentative (1952) postulate to the current Felkin-Anh-Heathcock formalism. For other reactions, only the currently accepted rationale is presented. Examination of these rationales also exposes the weaknesses of current theories, in that they cannot always explain the experimental observations. These shortcomings provide a challenge for future mechanistic investigations. Authoritative glossary to aid understanding of stereochemical terminology Explanations of the key factors influencing stereoselectivity with numerous examples, organized by reaction type A handy reference guide to the literature of asymmetric synthesis for practitioners in the field

Principles of Asymmetric Synthesis

Principles of Asymmetric Synthesis
  • Author : Robert E. Gawley,Jeffrey Aubé
  • Publisher : Elsevier
  • Release Date : 2012
  • Total pages : 555
  • ISBN : 0080448607
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Summary : The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present ...

Principles and Applications of Asymmetric Synthesis

Principles and Applications of Asymmetric Synthesis
  • Author : Guo-Qiang Lin,Yue-Ming Li,Albert S. C. Chan
  • Publisher : John Wiley & Sons
  • Release Date : 2003-05-29
  • Total pages : 536
  • ISBN : 0080448607
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Summary : Asymmetric synthesis remains a challenge to practicing scientistsas the need for enantiomerically pure or enriched compoundscontinues to increase. Over the last decade, a large amount ofliterature has been published in this field. Principles andApplications of Asymmetric Synthesis consolidates and evaluates themost useful methodologies into a one-volume resource for theconvenience of ...

Asymmetric Synthesis

Asymmetric Synthesis
  • Author : Garry Procter
  • Publisher : Oxford University Press on Demand
  • Release Date : 1996
  • Total pages : 237
  • ISBN : 0080448607
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Summary : This book covers a wide range of reactions which are of importance in the asymmetric synthesis of organic compounds. The principles of asymmetric additions to carbonyls, enolate alkylation, aldol reactions, additions to C-C double bonds, reduction and oxidation, rearrangements, and hydrolysis/ esterification reactions are covered, and selected examples used to ...

Principles of Asymmetric Synthesis

Principles of Asymmetric Synthesis
  • Author : Robert E. Gawley,Jeffrey Aubé
  • Publisher : Elsevier Science Limited
  • Release Date : 1996
  • Total pages : 372
  • ISBN : 0080448607
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Summary : The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present ...

Principles of Asymmetric Synthesis

Principles of Asymmetric Synthesis
  • Author : R.E. Gawley,J. Aubé
  • Publisher : Elsevier
  • Release Date : 1996-11-21
  • Total pages : 394
  • ISBN : 0080448607
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Summary : The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present ...

The Principles of Asymmetric Synthesis

The Principles of Asymmetric Synthesis
  • Author : Joseph Fredric Haskins
  • Publisher : Unknown
  • Release Date : 1920
  • Total pages : 26
  • ISBN : 0080448607
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Summary : Download or read online The Principles of Asymmetric Synthesis written by Joseph Fredric Haskins, published by which was released on 1920. Get The Principles of Asymmetric Synthesis Books now! Available in PDF, ePub and Kindle....

Asymmetric Synthesis

Asymmetric Synthesis
  • Author : Y. Vatsala
  • Publisher : Unknown
  • Release Date : 2014-03-01
  • Total pages : 178
  • ISBN : 0080448607
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Summary : Deals with stereochemistry of specialised topics. This book provides a comprehensive account of concepts of Asymmetric Synthesis. It is based on three important principles: concepts and terminology used in asymmetric synthesis, the four types of asymmetric synthesis, and applications of asymmetric synthesis....

Principles and Applications of Asymmetric Synthesis

Principles and Applications of Asymmetric Synthesis
  • Author : Guo-Qiang Lin,Yue-Ming Li,Albert S. C. Chan
  • Publisher : John Wiley & Sons
  • Release Date : 2001-02-21
  • Total pages : 536
  • ISBN : 0080448607
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Summary : Asymmetric synthesis remains a challenge to practicing scientists as the need for enantiomerically pure or enriched compounds continues to increase. Over the last decade, a large amount of literature has been published in this field. Principles and Applications of Asymmetric Synthesis consolidates and evaluates the most useful methodologies into a ...

Asymmetric Catalysis In Organic Synthesis

Asymmetric Catalysis In Organic Synthesis
  • Author : Ryoji Noyori
  • Publisher : Wiley-Interscience
  • Release Date : 1994-02-03
  • Total pages : 378
  • ISBN : 0080448607
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Summary : Deals with basic principles of asymmetric catalysis focusing on its synthetic significance. Covers homogeneous asymmetric hydrogenation, asymmetric catalysis via chiral metal complexes, heterogeneous catalysis and non-organometallic catalysis. The collection of a range of stereoselective reactions illustrate various strategies and methodologies as well as their general utility....

Chiral Reagents for Asymmetric Synthesis

Chiral Reagents for Asymmetric Synthesis
  • Author : Leo A. Paquette
  • Publisher : Wiley
  • Release Date : 2003-08-01
  • Total pages : 582
  • ISBN : 0080448607
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Summary : Derived from the renowned, Encyclopedia of Reagents for Organic Synthesis (EROS), the related editors have created a new handbook which focuses on chiral reagents used in asymmetric synthesis and is designed for the chemist at the bench. This new handbook follows the same format as the Encyclopedia, including an introduction ...

Dynamic Stereochemistry of Chiral Compounds

Dynamic Stereochemistry of Chiral Compounds
  • Author : Christian Wolf
  • Publisher : Royal Society of Chemistry
  • Release Date : 2008
  • Total pages : 512
  • ISBN : 0080448607
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Summary : A comprehensive overview of fundamental concepts of asymmetric synthesis along with in-depth discussion. Recent developments that address important synthetic challenges are presented and highlighted with hundreds of examples....

Asymmetric Synthesis

Asymmetric Synthesis
  • Author : R. Alan Aitken,S. Nicholas Kilényi
  • Publisher : Springer
  • Release Date : 2012-10-29
  • Total pages : 233
  • ISBN : 0080448607
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Summary : Very few fields in science have shown. such an acceleration from theory to practice as the field of asymIfletric synthesis. When one considers that the phrase 'asymmetric synthesis' was just a mechanistic curiosity in 1965 with no one seriously believing that this could someday be an important part of molecular synthesis, ...

Stereochemistry and Organic Reactions

Stereochemistry and Organic Reactions
  • Author : Dipak Kumar Mandal
  • Publisher : Academic Press
  • Release Date : 2021-04-26
  • Total pages : 638
  • ISBN : 0080448607
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Summary : Stereochemistry and Organic Reactions: Conformation, Configuration, Stereoelectronic Effects and Asymmetric Synthesis provides coverage on the stereochemistry of reactions of all mechanistic types, ranging from ionic, pericyclic and transition metal-catalyzed to radical and photochemical. Chapters cover acyclic molecules, cyclic molecules, the stereochemistry of organic reactions, the perturbation molecular orbital theory for ...

Synthesis of Prostaglandins

Synthesis of Prostaglandins
  • Author : Csaba Szántay,Lajos Novák
  • Publisher : Unknown
  • Release Date : 1978
  • Total pages : 267
  • ISBN : 0080448607
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Summary : Download or read online Synthesis of Prostaglandins written by Csaba Szántay,Lajos Novák, published by which was released on 1978. Get Synthesis of Prostaglandins Books now! Available in PDF, ePub and Kindle....

Handbook of Asymmetric Heterogeneous Catalysis

Handbook of Asymmetric Heterogeneous Catalysis
  • Author : Kuiling Ding,Yasuhiro Uozumi
  • Publisher : John Wiley & Sons
  • Release Date : 2008-09-08
  • Total pages : 466
  • ISBN : 0080448607
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Summary : In this most up-to-date handbook each chapter contains a general introduction, followed by the principles of the immobilization and, finally, applications. In this way, it covers the most important approaches currently employed for the heterogenization of chiral catalysts, including data tables, applications, reaction types and literature citations. For chemists in ...