Co localization of Polycystic Ovary Syndrome Candidate Gene Products in Human Theca Cells Suggests Novel Signaling Pathways

Written By Rewa M. Kulkarni
Co localization of Polycystic Ovary Syndrome Candidate Gene Products in Human Theca Cells Suggests Novel Signaling Pathways
  • Publsiher : Unknown
  • Release : 08 March 2021
  • ISBN : 0987654321
  • Pages : 212 pages
  • Rating : 4/5 from 21 reviews
GET THIS BOOKCo localization of Polycystic Ovary Syndrome Candidate Gene Products in Human Theca Cells Suggests Novel Signaling Pathways


Read or download book entitled Co localization of Polycystic Ovary Syndrome Candidate Gene Products in Human Theca Cells Suggests Novel Signaling Pathways written by Rewa M. Kulkarni which was release on 08 March 2021, this book published by Unknown. Available in PDF, EPUB and Kindle Format. Book excerpt: Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility and the most common endocrinopathy of women of reproductive age. Genome-wide association studies (GWAS) identified a number of loci associated PCOS in different ethnic populations, including women with Asian and European ancestry. Replication studies have confirmed some of these associations. Among the loci identified are those located near the LH receptor gene (LHCGR), a clathrin-binding protein gene (DENND1A) that also functions as a guanine nucleotide exchange factor, and the gene encoding RAB5B, a GTPase and protein involved in vesicular trafficking. The functional significance of one of these GWAS candidates (DENND1A) was supported by our discovery that a truncated protein splice variant of DENND1A termed DENND1A.V2, is elevated in PCOS theca cells, and that forced expression of DENND1A.V2 in normal theca cells increased CYP11A1 and CYP17A1 expression and androgen synthesis, a hallmark of PCOS. We previously proposed that the PCOS GWAS loci could be assembled into a functional network that contributes to altered gene expression in ovarian theca cells, resulting in increased androgen synthesis. Here we demonstrate the localization of LHCGR, DENND1AV. 2 and RAB5B proteins in various cellular compartments in normal and PCOS theca cells. hCG and forskolin stimulation affects the distribution and co-localization of DENND1A.V2 and RAB5B in various cellular compartments This cytological evidence supports our PCOS gene network concept, and raises the intriguing possibility that LHCGR activation, via a cAMP-mediated process, promotes the translocation of DENND1A.V2 and RAB5B-containing vesicles from the PCOS theca cell cytoplasm into the nucleus, resulting in increased transcription of genes involved in androgen synthesis.

Co localization of Polycystic Ovary Syndrome Candidate Gene Products in Human Theca Cells Suggests Novel Signaling Pathways

Co localization of Polycystic Ovary Syndrome Candidate Gene Products in Human Theca Cells Suggests Novel Signaling Pathways
  • Author : Rewa M. Kulkarni
  • Publisher : Unknown
  • Release Date : 2019
  • Total pages : 212
  • ISBN : 0987654321
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Summary : Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility and the most common endocrinopathy of women of reproductive age. Genome-wide association studies (GWAS) identified a number of loci associated PCOS in different ethnic populations, including women with Asian and European ancestry. Replication studies have confirmed some of these ...

Polycystic Ovary Syndrome

Polycystic Ovary Syndrome
  • Author : Gabor T. Kovacs,Robert Norman
  • Publisher : Cambridge University Press
  • Release Date : 2007-02-22
  • Total pages : 212
  • ISBN : 0987654321
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Summary : Polycystic ovary syndrome (PCOS) is one of the most common reproductive health problems of women. Despite this, its effective treatment remains a significant challenge to the medical profession. This second edition (published 2007) of a highly successful and well-reviewed book is a thorough update on the syndrome, its aetiology, pathology, impact ...

Quercetin Decreases Insulin Resistance in a Polycystic Ovary Syndrome Rat Model by Improving Inflammatory Microenvironment

Quercetin Decreases Insulin Resistance in a Polycystic Ovary Syndrome Rat Model by Improving Inflammatory Microenvironment
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2021-03-08
  • Total pages : 212
  • ISBN : 0987654321
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Summary : Download or read online Quercetin Decreases Insulin Resistance in a Polycystic Ovary Syndrome Rat Model by Improving Inflammatory Microenvironment written by , published by which was released on . Get Quercetin Decreases Insulin Resistance in a Polycystic Ovary Syndrome Rat Model by Improving Inflammatory Microenvironment Books now! Available in PDF, ePub and ...

A Patient s Guide to PCOS

A Patient s Guide to PCOS
  • Author : Walter Futterweit, M.D.,George Ryan
  • Publisher : Holt Paperbacks
  • Release Date : 2006-03-21
  • Total pages : 272
  • ISBN : 0987654321
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Summary : A comprehensive guide to polycystic ovary syndrome, from a leading authority on the condition One in ten American women of childbearing age is affected by polycystic ovary syndrome (PCOS) to some degree, and many suffer from serious symptoms, such as infertility, early miscarriage, chronic pelvic pain, weight gain, high blood ...

The Polycystic Ovary Syndrome

The Polycystic Ovary Syndrome
  • Author : Duru Shah,R. K. Bhathena,Safala Shroff
  • Publisher : Orient Blackswan
  • Release Date : 2004
  • Total pages : 214
  • ISBN : 0987654321
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Summary : This Is An Important Condition In Gynecologic Practice. The Book Will Take Up Clinical Presentation, Diagnosis And Treatment Of The Disorder. The Book Is Contributory In Nature. This Book Will Be Useful For Postgraduate Students And Practicing Gynecologists...

The PCOS Plan

The PCOS Plan
  • Author : Nadia Brito Pateguana,Jason Fung
  • Publisher : Greystone Books Ltd
  • Release Date : 2020-04-14
  • Total pages : 224
  • ISBN : 0987654321
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Summary : New York Times bestselling author Dr. Jason Fung joins forces with naturopathic doctor Nadia Pateguana to offer methods to prevent and reverse PCOS through diet and intermittent fasting. Polycystic Ovary Syndrome (PCOS) is the most common reproductive disorder in the world, affecting an estimated eight to 20 percent of women of ...

Hyperandrogenism in Women

Hyperandrogenism in Women
  • Author : R. Pasquali,D. Pignatelli
  • Publisher : Karger Medical and Scientific Publishers
  • Release Date : 2019-09-09
  • Total pages : 192
  • ISBN : 0987654321
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Summary : Hyperandrogenism profoundly affects women’s lives from lowering self-esteem to changing cognition and affective motivation. The polycystic ovary syndrome (PCOS) is the most common androgen excess disorder worldwide. While it is not the focus of this book, some aspects are discussed. The aim of this book is to improve understanding ...

Cumulated Index Medicus

Cumulated Index Medicus
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1999
  • Total pages : 212
  • ISBN : 0987654321
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Summary : Download or read online Cumulated Index Medicus written by , published by which was released on 1999. Get Cumulated Index Medicus Books now! Available in PDF, ePub and Kindle....

Polycystic Ovary Syndrome

Polycystic Ovary Syndrome
  • Author : R. Jeffrey Chang,Serono Symposia, USA.
  • Publisher : Springer
  • Release Date : 1996-10-25
  • Total pages : 370
  • ISBN : 0987654321
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Summary : The term polycystic ovary syndrome (peOS) is meant to describe a clinical endocrinopathy characterized by menstrual irregularity and evidence of hyperandrogenism. While recognized since the 1800s, a clinical composite was not constructed until 1935 when Stein and Leventhal reported their findings of seven women with infertility, menstrual dysfunction, hirsutism, and enlarged ...

Oxford Textbook of Obstetrics and Gynaecology

Oxford Textbook of Obstetrics and Gynaecology
  • Author : Sabaratnam Arulkumaran,William Ledger,Stergios Doumouchtsis,Lynette Denny
  • Publisher : Oxford University Press, USA
  • Release Date : 2019-12
  • Total pages : 928
  • ISBN : 0987654321
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Summary : The Oxford Textbook of Obstetrics and Gynaecology is an up-to-date, objective and readable text that covers the full speciality of Obstetrics and Gynaecology. This comprehensive and rigorously referenced textbook will be a vital resource in print and online for all practising clinicians. Edited by a team of four leading figures ...

PCOS

PCOS
  • Author : Colette Harris,Adam Carey
  • Publisher : HarperCollins UK
  • Release Date : 2000
  • Total pages : 211
  • ISBN : 0987654321
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Summary : The bestselling guide to this increasingly common womens' health concern....

A Guide to the Polycystic Ovary

A Guide to the Polycystic Ovary
  • Author : Gabor Kovacs,Jane Smith
  • Publisher : Tfm Pub Limited
  • Release Date : 2002
  • Total pages : 120
  • ISBN : 0987654321
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Summary : Several studies have looked at populations of volunteers, women from the electoral roll and women attending general practices, and have reported the ultrasound appearance of polycystic ovaries in as many as one in three to one in five. If groups of women with irregular periods are looked at, up to 90% ...

Polycystic Ovary Syndrome

Polycystic Ovary Syndrome
  • Author : Gautam Allahbadia,Rina Agrawal
  • Publisher : Anshan
  • Release Date : 2007
  • Total pages : 497
  • ISBN : 0987654321
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Summary : Our knowledge about infertility has expanded and improved significantly in recent years and Polycystic Ovary Syndrome (PCOS) is now recognised as a major cause. PCOS is a term which covers a variety of symptoms, and in this new volume the editors have compiled a wide ranging collection of studies dealing ...

Endocrinology

Endocrinology
  • Author : Leslie J. DeGroot
  • Publisher : Unknown
  • Release Date : 2006
  • Total pages : 3633
  • ISBN : 0987654321
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Summary : Revised throughout, the 5th Edition presents a complete and up-to-date review and analysis of all aspects of endocrinology, diabetes, and bone metabolism. Readers will also find state-of-the-art information on genetics, proteinomics, and hormone signaling, and coverage of the field{19}s hottest topics in nearly 20 new chapters. Joined by an international ...

Polycystic Ovary Syndrome

Polycystic Ovary Syndrome
  • Author : Andrea Dunaif,R. Jeffrey Chang,Stephen Franks,Richard S. Legro
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-01-12
  • Total pages : 350
  • ISBN : 0987654321
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Summary : This volume includes the latest diagnostic criteria for PCOS and comprises the most up-to-date information about the genetic features and pathogenesis of PCOS. It critically reviews the methodological approaches and the evidence for various PCOS susceptibility genes. The book also discusses additional familial phenotypes of PCOS and their potential genetic ...