Physiologically Based Pharmacokinetic PBPK Modeling and Simulations

Written By Sheila Annie Peters
Physiologically Based Pharmacokinetic  PBPK  Modeling and Simulations
  • Publsiher : John Wiley & Sons
  • Release : 17 February 2012
  • ISBN : 1118140303
  • Pages : 450 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Physiologically Based Pharmacokinetic PBPK Modeling and Simulations written by Sheila Annie Peters which was release on 17 February 2012, this book published by John Wiley & Sons. Available in PDF, EPUB and Kindle Format. Book excerpt: The only book dedicated to physiologically-based pharmacokineticmodeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has becomeincreasingly widespread within the pharmaceutical industry over thelast decade, but without one dedicated book that provides theinformation researchers need to learn these new techniques, itsapplications are severely limited. Describing the principles,methods, and applications of PBPK modeling as used inpharmaceutics, Physiologically-Based Pharmacokinetic (PBPK)Modeling and Simulations fills this void. Connecting theory with practice, the book explores theincredible potential of PBPK modeling for improving drug discoveryand development. Comprised of two parts, the book first provides adetailed and systematic treatment of the principles behindphysiological modeling of pharmacokinetic processes,inter-individual variability, and drug interactions for smallmolecule drugs and biologics. The second part looks in greaterdetail at the powerful applications of PBPK to drug research. Designed for a wide audience encompassing readers looking for abrief overview of the field as well as those who need more detail,the book includes a range of important learning aids. Featuringend-of-chapter keywords for easy reference—a valuable assetfor general or novice readers without a PBPK background—alongwith an extensive bibliography for those looking for furtherinformation, Physiologically- Based Pharmacokinetic (PBPK) Modelingand Simulations is the essential single-volume text on one of thehottest topics in the pharmaceutical sciences today.

Physiologically Based Pharmacokinetic PBPK Modeling and Simulations

Physiologically Based Pharmacokinetic  PBPK  Modeling and Simulations
  • Author : Sheila Annie Peters
  • Publisher : John Wiley & Sons
  • Release Date : 2012-02-17
  • Total pages : 450
  • ISBN : 1118140303
GET BOOK

Summary : The only book dedicated to physiologically-based pharmacokineticmodeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has becomeincreasingly widespread within the pharmaceutical industry over thelast decade, but without one dedicated book that provides theinformation researchers need to learn these new techniques, itsapplications are severely limited. Describing the principles,methods, and applications of ...

Translational Physiologically based Pharmacokinetic PBPK Modeling and Simulation to Support Drug Development and Pharmacotherapy

Translational Physiologically based Pharmacokinetic  PBPK  Modeling and Simulation to Support Drug Development and Pharmacotherapy
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2018
  • Total pages : 212
  • ISBN : 1118140303
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Summary : Download or read online Translational Physiologically based Pharmacokinetic PBPK Modeling and Simulation to Support Drug Development and Pharmacotherapy written by , published by which was released on 2018. Get Translational Physiologically based Pharmacokinetic PBPK Modeling and Simulation to Support Drug Development and Pharmacotherapy Books now! Available in PDF, ePub and Kindle....

Physiologically Based Pharmacokinetic Modeling

Physiologically Based Pharmacokinetic Modeling
  • Author : Micaela Reddy,R. S. Yang,Melvin E. Andersen,Harvey J. Clewell III
  • Publisher : John Wiley & Sons
  • Release Date : 2005-06-14
  • Total pages : 420
  • ISBN : 1118140303
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Summary : A definitive, single source of information on PBPK modeling Physiologically-based pharmacokinetic (PBPK) modeling is becomingincreasingly important in human health risk assessments and insupporting pharmacodynamic modeling for toxic responses. Organizedby classes of compounds and modeling purposes so users can quicklyaccess information, this is the first comprehensive reference ofits kind. This book ...

Physiologically Based Pharmacokinetic PBPK Model Development of Perfluorocarboxylic Acids for Rats and Humans

Physiologically Based Pharmacokinetic  PBPK  Model Development of Perfluorocarboxylic Acids for Rats and Humans
  • Author : 晴美
  • Publisher : Unknown
  • Release Date : 2013
  • Total pages : 212
  • ISBN : 1118140303
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Summary : Download or read online Physiologically Based Pharmacokinetic PBPK Model Development of Perfluorocarboxylic Acids for Rats and Humans written by 晴美, published by which was released on 2013. Get Physiologically Based Pharmacokinetic PBPK Model Development of Perfluorocarboxylic Acids for Rats and Humans Books now! Available in PDF, ePub and Kindle....

Physiologically Based Pharmacokinetic Toxicokinetic Modeling in Risk Assessment

Physiologically Based Pharmacokinetic Toxicokinetic Modeling in Risk Assessment
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2005
  • Total pages : 40
  • ISBN : 1118140303
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Summary : Physiologically-based pharmacokinetic (PBPK) modeling has become the tool of choice to develop estimates of target site dosimetries in animals and humans for risk assessment purposes. PBPK model compartments correspond directly to the tissues and organs in the species. The drawbacks of PBPK modeling primarily relate to the time, effort and ...

Approaches for the Application of Physiologically Based Pharmacokinetic PBPK Models and Supporting Data in Risk Assessment

Approaches for the Application of Physiologically Based Pharmacokinetic  PBPK  Models and Supporting Data in Risk Assessment
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2006
  • Total pages : 123
  • ISBN : 1118140303
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Summary : Download or read online Approaches for the Application of Physiologically Based Pharmacokinetic PBPK Models and Supporting Data in Risk Assessment written by , published by which was released on 2006. Get Approaches for the Application of Physiologically Based Pharmacokinetic PBPK Models and Supporting Data in Risk Assessment Books now! Available in PDF, ...

Physiologically Based Pharmacokinetic Modeling

Physiologically Based Pharmacokinetic Modeling
  • Author : Jasmine Davda
  • Publisher : LAP Lambert Academic Publishing
  • Release Date : 2009-08
  • Total pages : 112
  • ISBN : 1118140303
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Summary : This book describes the application of physiologically based pharmacokinetic (PBPK) modeling to characterize the disposition of therapeutic monoclonal antibodies (MAbs). These macromolecules exhibit distinctly different pharmacokinetic features compared with conventional small-molecule drugs. A PBPK model was developed to characterize the biodistribution of the pancarcinoma MAb CC49 in normal and neoplastic ...

CYP450 mediated Drug drug Interactions

CYP450 mediated Drug drug Interactions
  • Author : Niloufar Marsousi
  • Publisher : Unknown
  • Release Date : 2017
  • Total pages : 214
  • ISBN : 1118140303
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Summary : Download or read online CYP450 mediated Drug drug Interactions written by Niloufar Marsousi, published by which was released on 2017. Get CYP450 mediated Drug drug Interactions Books now! Available in PDF, ePub and Kindle....

A Parameter Analysis of a Physiologically Based Pharmacokinetic PBPK Model Describing the Movements of 2 3 7 8 tetrachlorodibenzo p dioxin in the Mouse

A Parameter Analysis of a Physiologically Based Pharmacokinetic  PBPK  Model Describing the Movements of 2 3 7 8 tetrachlorodibenzo p dioxin in the Mouse
  • Author : Jessica Leigh Wagner
  • Publisher : Unknown
  • Release Date : 2017
  • Total pages : 60
  • ISBN : 1118140303
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Summary : Download or read online A Parameter Analysis of a Physiologically Based Pharmacokinetic PBPK Model Describing the Movements of 2 3 7 8 tetrachlorodibenzo p dioxin in the Mouse written by Jessica Leigh Wagner, published by which was released on 2017. Get A Parameter Analysis of a Physiologically Based Pharmacokinetic PBPK Model Describing the Movements of 2 3 7 8 ...

A General and Age dependent Physiological Based Pharmacokinetic PBPK Model Development

A General and Age dependent Physiological Based Pharmacokinetic  PBPK  Model Development
  • Author : Xianping Tong
  • Publisher : Unknown
  • Release Date : 2006
  • Total pages : 134
  • ISBN : 1118140303
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Summary : Download or read online A General and Age dependent Physiological Based Pharmacokinetic PBPK Model Development written by Xianping Tong, published by which was released on 2006. Get A General and Age dependent Physiological Based Pharmacokinetic PBPK Model Development Books now! Available in PDF, ePub and Kindle....

Physiologically Based Pharmacokinetic PBPK Models for the Description of Sequential Metabolism of Codeine to Morphine and Morphine 3 Glucuronide M3G in Man and Rat

Physiologically Based Pharmacokinetic  PBPK  Models for the Description of Sequential Metabolism of Codeine to Morphine and Morphine 3 Glucuronide  M3G  in Man and Rat
  • Author : Shu Chen
  • Publisher : Unknown
  • Release Date : 2010
  • Total pages : 250
  • ISBN : 1118140303
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Summary : Whole-body PBPK models were developed based on both the intestinal traditional model (TM) and segregated-flow model (SFM) to describe codeine sequential metabolism in man/rat. Model parameters were optimized with ScientistRTM and SimcypRTM simulator to predict literature data after oral (p.o.) and intravenous (i.v.) codeine administration in man/...

Providing a Theoretical Basis for Nanotoxicity Risk Analysis Departing from Traditional Physiologically based Pharmacokinetic PBPK Modeling

Providing a Theoretical Basis for Nanotoxicity Risk Analysis Departing from Traditional Physiologically based Pharmacokinetic  PBPK  Modeling
  • Author : Dirk P. Yamamoto
  • Publisher : Unknown
  • Release Date : 2010
  • Total pages : 376
  • ISBN : 1118140303
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Summary : Download or read online Providing a Theoretical Basis for Nanotoxicity Risk Analysis Departing from Traditional Physiologically based Pharmacokinetic PBPK Modeling written by Dirk P. Yamamoto, published by which was released on 2010. Get Providing a Theoretical Basis for Nanotoxicity Risk Analysis Departing from Traditional Physiologically based Pharmacokinetic PBPK Modeling Books now! ...

A Comparison of Physiologically Based Pharmacokinetic PBPK Models of Methyl Tertiary Butyl Ether MTBE

A Comparison of Physiologically Based Pharmacokinetic  PBPK  Models of Methyl Tertiary Butyl Ether  MTBE
  • Author : Nikki Shavon Smith
  • Publisher : Unknown
  • Release Date : 2018
  • Total pages : 124
  • ISBN : 1118140303
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Summary : Download or read online A Comparison of Physiologically Based Pharmacokinetic PBPK Models of Methyl Tertiary Butyl Ether MTBE written by Nikki Shavon Smith, published by which was released on 2018. Get A Comparison of Physiologically Based Pharmacokinetic PBPK Models of Methyl Tertiary Butyl Ether MTBE Books now! Available in PDF, ePub ...

Physiologically Based Pharmacokinetic PBPK Modelling of Cisplatin in Rats and Humans

Physiologically Based Pharmacokinetic  PBPK  Modelling of Cisplatin in Rats and Humans
  • Author : Hyunjin Park
  • Publisher : Unknown
  • Release Date : 2019
  • Total pages : 212
  • ISBN : 1118140303
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Summary : The physiologically based pharmacokinetic (PBPK) modelling has been accepted as one of the most effective mechanistic techniques to analyze pharmacokinetics (PK) of drugs in the drug development process. Its effectiveness in predicting the PK of drugs is important not only to the current drug development industry but also to potential ...

Consequences of a Lack of Adult Intravenous Data on the Prediction Accuracy of Pediatric Physiologically Based Pharmacokinetic PBPK Modeling

Consequences of a Lack of Adult Intravenous Data on the Prediction Accuracy of Pediatric Physiologically Based Pharmacokinetic  PBPK  Modeling
  • Author : Rabiya Chandani
  • Publisher : Unknown
  • Release Date : 2015
  • Total pages : 130
  • ISBN : 1118140303
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Summary : Lack of pediatric clinical data has led to a large gap in knowledge concerning drug efficacy, safety and dosing guidelines within the pediatric population. Many pediatric off-label doses are based largely on adult studies with little or no pediatric experience; this has the potential to lead to treatment failures, toxicities, ...