A Mechanistic and Functional Study of White opaque Phenotypic Switching in Candida Albicans

Written By Mathew Gregory Miller
A Mechanistic and Functional Study of White opaque Phenotypic Switching in Candida Albicans
  • Publsiher : Unknown
  • Release : 03 March 2021
  • ISBN : 0987654321
  • Pages : 340 pages
  • Rating : 4/5 from 21 reviews
GET THIS BOOKA Mechanistic and Functional Study of White opaque Phenotypic Switching in Candida Albicans


Read or download book entitled A Mechanistic and Functional Study of White opaque Phenotypic Switching in Candida Albicans written by Mathew Gregory Miller which was release on 03 March 2021, this book published by Unknown. Available in PDF, EPUB and Kindle Format. Book excerpt: Candida albicans is a major fungal pathogen of humans. It is a harmless commensal in healthy individuals, but it can cause serious infections in immune-compromised hosts. C. albicans undergoes a meta-stable and reversible switch between two distinct cell types known as white and opaque. The role of white-opaque switching in the biology of C. albicans was originally not well understood. We discovered an unexpected relationship between white-opaque switching and the sexual cycle of C. albicans . The mating type locus of C. albicans (MTL) encodes transcriptional regulatory proteins that regulate mating. We demonstrated that two MTL -encoded homeodomain proteins, a 1 and alpha2, work together to repress white-opaque switching in C. albicans . The observations that the MTL locus controlled both mating and white-opaque switching led us to hypothesize that opaque cells played a role in mating. Indeed, we found that opaque cells mate one million times more efficiently than do white cells. Additionally, opaque cells, but not white cells, developed specialized mating projections when exposed to mating pheromone. Thus, opaque cells are a specialized mating form of C. albicans . As white cells are generally more robust in a mammalian host than opaque cells, this strategy allows the organism to survive the rigors of life within a mammalian host, while generating a small population of mating-competent cells. The mechanism that controls white-opaque switching is not well understood. To better understand the mechanism, we investigated the regulation of white-opaque switching by a 1-alpha2. We demonstrated that a 1-alpha2 regulates white-opaque switching by destabilizing opaque cells, and we monitored gene expression during the transition from opaque to white using DNA microarrays. We used a candidate approach to identify additional regulators of white-opaque switching among genes enriched for their expression in the opaque phase. We identified two potent positive regulators of white-opaque switching: the opaque-specific transcriptional regulatory proteins Czf1 and Naf1. We also further investigated the role of Efg1, a previously identified regulator of white-opaque switching, and found that efg1/efg1 mutants were unable to bypass a 1-alpha2 repression of switching. Finally, we determined the epistatic and regulatory relationships between Efg1, Czf1 and Naf1.

A Mechanistic and Functional Study of White opaque Phenotypic Switching in Candida Albicans

A Mechanistic and Functional Study of White opaque Phenotypic Switching in Candida Albicans
  • Author : Mathew Gregory Miller
  • Publisher : Unknown
  • Release Date : 2005
  • Total pages : 340
  • ISBN : 0987654321
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Summary : Candida albicans is a major fungal pathogen of humans. It is a harmless commensal in healthy individuals, but it can cause serious infections in immune-compromised hosts. C. albicans undergoes a meta-stable and reversible switch between two distinct cell types known as white and opaque. The role of white-opaque switching in ...

Phenotypic Switching

Phenotypic Switching
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  • Publisher : Academic Press
  • Release Date : 2020-06-10
  • Total pages : 762
  • ISBN : 0987654321
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Summary : Phenotypic Switching: Implications in Biology and Medicine provides a comprehensive examination of phenotypic switching across biological systems, including underlying mechanisms, evolutionary significance, and its role in biomedical science. Contributions from international leaders discuss conceptual and theoretical aspects of phenotypic plasticity, its influence over biological development, differentiation, biodiversity, and potential applications ...

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Summary : Inflammatory Disorders - Part B, Volume 120 explores inflammation in the immune system and how the body's own cells or tissues may cause abnormal inflammation, thus resulting in chronic pain, redness, swelling, stiffness, and damage to normal tissues. Chapters in this updated volume include Proteins in monogenic autoinflammatory disorders, Virulence factors ...

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Summary : Now expanded with the latest information of relevance to current dental practice, Oral Microbiology retains its unique ecological approach to the subject which helps the reader determine whether an organism will have a pathogenic or commensal relationship at a given site. In the new edition, greater emphasis is placed on ...

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  • Author : National Academy of Sciences (U.S.)
  • Publisher : Unknown
  • Release Date : 2007
  • Total pages : 212
  • ISBN : 0987654321
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Summary : Download or read online Proceedings of the National Academy of Sciences of the United States of America written by National Academy of Sciences (U.S.), published by which was released on 2007. Get Proceedings of the National Academy of Sciences of the United States of America Books now! Available in PDF, ...

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  • Publisher : Academic Press
  • Release Date : 2020-05
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  • ISBN : 0987654321
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Summary : Protein Interactions as Targets in Drug Discovery, Volume 121, is dedicated to the design of therapeutics, both experimental and computational, that target protein interactions. Chapters in this new release include Trends in structure based drug design with protein targets, From fragment- to peptide-protein interaction: addressing the structural basis of binding using ...

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Summary : Download or read online Bibliography of Agriculture written by , published by which was released on 1990. Get Bibliography of Agriculture Books now! Available in PDF, ePub and Kindle....

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Summary : Download or read online Microbiology written by , published by which was released on 1997. Get Microbiology Books now! Available in PDF, ePub and Kindle....

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  • Author : Anonim
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Summary : Download or read online Archives of Medical Research written by , published by which was released on 1993. Get Archives of Medical Research Books now! Available in PDF, ePub and Kindle....

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Smithsonian Contributions to Zoology
  • Author : Smithsonian Institution
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Summary : Download or read online Smithsonian Contributions to Zoology written by Smithsonian Institution, published by which was released on 1969. Get Smithsonian Contributions to Zoology Books now! Available in PDF, ePub and Kindle....

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Summary : The first textbook of mycology ever to focus on the management of patients with fungal infections, CLINICAL MYCOLOGY represents an expert, authoritative examination of clinical problem-solving approaches to diagnosis and management. It offers specific recommendations for understanding, controlling, and preventing fungal infections based on underlying principles of epidemiology and infection ...

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  • Publisher : Quintessence Publishing (IL)
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Summary : Brings together the papers presented at this important 1993 workshop. Addressed is a wide array of issues of interest to the dental practitioner and researcher, from oral lesions to periodontal concerns to provision of care and infection control practices. [editor]....

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  • Publisher : Unknown
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Summary : Download or read online The Life History and Ecology of the Entocytherid Ostracod Uncinocythere Occidentalis Kozloff and Whitman in Idaho written by C. W. Hart, published by which was released on 1985. Get The Life History and Ecology of the Entocytherid Ostracod Uncinocythere Occidentalis Kozloff and Whitman in Idaho Books now! ...

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Summary : Download or read online Postnaupliar Development of a Looking glass written by Frank D. Ferrari, published by which was released on 1985. Get Postnaupliar Development of a Looking glass Books now! Available in PDF, ePub and Kindle....

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  • ISBN : 0987654321
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Summary : Proceedings of a workshop held at the U. of Florida Health Center in Gainesville, February 1989. Surveys and evaluates the status of research in the related fields of bacteriology, mycology, immunology, and host-parasite relationships. The five sections address bacterial factors; fungal factors; bacterial factors in sexually transmitted diseases; biologic factors; and ...