Pharmacology in Drug Discovery and Development

Written By Terry Kenakin
Pharmacology in Drug Discovery and Development
  • Publsiher : Academic Press
  • Release : 21 October 2016
  • ISBN : 0128037539
  • Pages : 350 pages
  • Rating : 4/5 from 21 reviews
GET THIS BOOKPharmacology in Drug Discovery and Development


Read or download book entitled Pharmacology in Drug Discovery and Development written by Terry Kenakin which was release on 21 October 2016, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: Pharmacology in Drug Discovery and Development: Understanding Drug Response, Second Edition, is an introductory resource illustrating how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. The concepts discussed in this book allow for the application of more predictive pharmacological procedures aimed at increasing therapeutic efficacy that will lead to more successful drug development. Chapters logically build upon one another to show how to characterize the pharmacology of any given molecule and allow for more informed predictions of drug effects in all biological systems. New chapters are dedicated to the interdisciplinary drug discovery environment in both industry and academia, and special techniques involved in new drug screening and lead optimization. This edition has been fully revised to address the latest advances and research related to real time kinetic assays, pluridimensional efficacy, signaling bias, irreversible and chemical antagonism, allosterically-induced bias, pharmacokinetics and safety, target and pathway validation, and much more. With numerous valuable chapter summaries, detailed references, practical examples and case studies throughout, Dr. Kenakin successfully navigates a highly complex subject, making it accessible for students, professors, and new researchers working in pharmacology and drug discovery. Includes example-based cases that illustrate how the pharmacological concepts discussed in this book lead to practical outcomes for further research Provides vignettes on those researchers and scientists who have contributed significantly to the fields of pharmacology and drug discovery throughout history Offers sample questions throughout the book and an appendix containing answers for self-testing and retention

Pharmacology in Drug Discovery and Development

Pharmacology in Drug Discovery and Development
  • Author : Terry Kenakin
  • Publisher : Academic Press
  • Release Date : 2016-10-21
  • Total pages : 350
  • ISBN : 0128037539
GET BOOK

Summary : Pharmacology in Drug Discovery and Development: Understanding Drug Response, Second Edition, is an introductory resource illustrating how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. The concepts discussed in this book ...

Pharmacology for Chemists

Pharmacology for Chemists
  • Author : Raymond Hill,Terry Kenakin,Tom Blackburn
  • Publisher : Royal Society of Chemistry
  • Release Date : 2017-10-25
  • Total pages : 524
  • ISBN : 0128037539
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Summary : Assuming little previous knowledge of biology, this book aids graduate chemists to close the gap in their knowledge of pharmacology and make the link between medicinal chemistry and the way in which drugs act on the body. The availability of receptor structures has revolutionized drug discovery and development necessitating an ...

Drug Discovery and Evaluation Pharmacological Assays

Drug Discovery and Evaluation  Pharmacological Assays
  • Author : Hans G. Vogel
  • Publisher : Springer Science & Business Media
  • Release Date : 2002-06-13
  • Total pages : 1408
  • ISBN : 0128037539
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Summary : Now expanded and updated to include molecular biology and genetic engineering techniques. The second edition of this successful reference book contains a comprehensive selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Each of the more than 1000 assays comprises a detailed protocol outlining ...

Innovative Approaches in Drug Discovery

Innovative Approaches in Drug Discovery
  • Author : Bhushan Patwardhan,Rathnam Chaguturu
  • Publisher : Academic Press
  • Release Date : 2016-10-03
  • Total pages : 480
  • ISBN : 0128037539
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Summary : Despite considerable technological advances, the pharmaceutical industry is experiencing a severe innovation deficit, especially in the discovery of new drugs. Innovative Approaches in Drug Discovery: Ethnopharmacology, Systems Biology and Holistic Targeting provides a critical review and analysis of health, disease and medicine, and explores possible reasons behind the present crisis ...

Translational Medicine

Translational Medicine
  • Author : Robert A. Meyers
  • Publisher : John Wiley & Sons
  • Release Date : 2018-07-16
  • Total pages : 1064
  • ISBN : 0128037539
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Summary : This reference work gives a compete overview of the different stages of drug development using a translational approach. The book is structured in different parts, following the different stages in drug development. Almost half of the work is dedicated to core of drug discovery using a translational approach, the identification ...

Pharmaceutical Profiling in Drug Discovery for Lead Selection

Pharmaceutical Profiling in Drug Discovery for Lead Selection
  • Author : Ronald Borchardt,Edward Kerns,Christopher Lipinski,Dhrien Thakker,Binghe Wang
  • Publisher : Springer Science & Business Media
  • Release Date : 2005-12-05
  • Total pages : 482
  • ISBN : 0128037539
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Summary : This volume focuses on how to increase the efficiency of drug discovery and development. It is written by experienced discovery scientists from diverse disciplines, including chemistry, drug metabolism, and development sciences. The volume details in silico, in vitro, and in vivo tools for prediction, measurement, and application of compound properties ...

Antiepileptic Drug Discovery

Antiepileptic Drug Discovery
  • Author : Alan Talevi,Luisa Rocha
  • Publisher : Humana Press
  • Release Date : 2016-09-24
  • Total pages : 386
  • ISBN : 0128037539
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Summary : This thorough volume delves into antiepileptic drug discovery with a comprehensive collection of innovative approaches for the development of antiepileptic therapies, focusing on novel molecular targets for antiepileptic drugs, computer-aided approaches for the identification of new drug candidates, and therapeutic strategies to overcome refractory epilepsy. The last section illustrates the ...

Pharmacological Advances in Natural Product Drug Discovery

Pharmacological Advances in Natural Product Drug Discovery
  • Author : Guanhua Du
  • Publisher : Academic Press
  • Release Date : 2020-03
  • Total pages : 312
  • ISBN : 0128037539
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Summary : Pharmacological Advances in Natural Product Drug Discovery, Volume 87 in the Advances in Pharmacology series, presents the latest pharmacological research progresses of 8 medicinal compounds from natural products, including salvianolic acid, tanshinone, paeonol, chlorogenic acid, astragaloside, icariin, ganoderan, and febrifugine. Specific chapters to this new release include Potential Role of Paeonol on ...

Drug Discovery and Clinical Research

Drug Discovery and Clinical Research
  • Author : SK Gupta
  • Publisher : JP Medical Ltd
  • Release Date : 2011-06-01
  • Total pages : 668
  • ISBN : 0128037539
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Summary : The Drug Discovery and Clinical Research bandwagon has been joined by scientists and researchers from all fields including basic sciences, medical sciences, biophysicists, biotechnologists, statisticians, regulatory officials and many more. The joint effort and contribution from all is translating into the fast development of this multi-faceted field. At the same ...

Modern Methods of Drug Discovery

Modern Methods of Drug Discovery
  • Author : Alexander Hillisch,Rolf Hilgenfeld
  • Publisher : Springer Science & Business Media
  • Release Date : 2002-12-11
  • Total pages : 292
  • ISBN : 0128037539
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Summary : Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach ...

Biomarker Methods in Drug Discovery and Development

Biomarker Methods in Drug Discovery and Development
  • Author : Feng Wang
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-03-11
  • Total pages : 396
  • ISBN : 0128037539
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Summary : In this book, expert researchers provide a tool box for those who have a general interest in biomarker research and for those currently specializing in certain technologies but desiring an understanding of other available methodologies. Its chapters include validated, mature methods as well as new, incredibly promising protocols. This book ...

Drug Discovery and Development

Drug Discovery and Development
  • Author : Michael Williams,Jeffrey B. Malick
  • Publisher : Springer Science & Business Media
  • Release Date : 1987-08-27
  • Total pages : 447
  • ISBN : 0128037539
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Summary : The conceptual process of drug discovery is one that is often the result of an identified need in a defined disease area. This need represents a mandate from the marketing department of a phar­ maceutical company or a breakthrough at the research level that has agreed applicability in response to ...

Drug Discovery and Evaluation Methods in Clinical Pharmacology

Drug Discovery and Evaluation  Methods in Clinical Pharmacology
  • Author : H.Gerhard Vogel,Jochen Maas,Alexander Gebauer
  • Publisher : Springer
  • Release Date : 2011-02-03
  • Total pages : 564
  • ISBN : 0128037539
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Summary : Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these ...

Toxins in Drug Discovery and Pharmacology

Toxins in Drug Discovery and Pharmacology
  • Author : Steve Peigneur
  • Publisher : MDPI
  • Release Date : 2018-05-04
  • Total pages : 316
  • ISBN : 0128037539
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Summary : This book is a printed edition of the Special Issue "Toxins in Drug Discovery and Pharmacology" that was published in Toxins...

Drug Discovery and Evaluation Safety and Pharmacokinetic Assays

Drug Discovery and Evaluation  Safety and Pharmacokinetic Assays
  • Author : H. Gerhard Vogel,Jochen Maas,Franz J. Hock,Dieter Mayer
  • Publisher : Springer
  • Release Date : 2013-02-27
  • Total pages : 1404
  • ISBN : 0128037539
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Summary : -A landmark in the continuously changing world of drugs -Essential reading for scientists and managers in the pharmaceutical industry involved in drug finding, drug development and decision making in the development process -Of use for government institutions and committees working on official guidelines for drug evaluation worldwide...