Pharmacology in Drug Discovery and Development

Written By Terry Kenakin
Pharmacology in Drug Discovery and Development
  • Publsiher : Academic Press
  • Release : 21 October 2016
  • ISBN : 0128037539
  • Pages : 350 pages
  • Rating : 4/5 from 21 reviews
GET THIS BOOKPharmacology in Drug Discovery and Development


Read or download book entitled Pharmacology in Drug Discovery and Development written by Terry Kenakin which was release on 21 October 2016, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: Pharmacology in Drug Discovery and Development: Understanding Drug Response, Second Edition, is an introductory resource illustrating how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. The concepts discussed in this book allow for the application of more predictive pharmacological procedures aimed at increasing therapeutic efficacy that will lead to more successful drug development. Chapters logically build upon one another to show how to characterize the pharmacology of any given molecule and allow for more informed predictions of drug effects in all biological systems. New chapters are dedicated to the interdisciplinary drug discovery environment in both industry and academia, and special techniques involved in new drug screening and lead optimization. This edition has been fully revised to address the latest advances and research related to real time kinetic assays, pluridimensional efficacy, signaling bias, irreversible and chemical antagonism, allosterically-induced bias, pharmacokinetics and safety, target and pathway validation, and much more. With numerous valuable chapter summaries, detailed references, practical examples and case studies throughout, Dr. Kenakin successfully navigates a highly complex subject, making it accessible for students, professors, and new researchers working in pharmacology and drug discovery. Includes example-based cases that illustrate how the pharmacological concepts discussed in this book lead to practical outcomes for further research Provides vignettes on those researchers and scientists who have contributed significantly to the fields of pharmacology and drug discovery throughout history Offers sample questions throughout the book and an appendix containing answers for self-testing and retention

Pharmacology in Drug Discovery and Development

Pharmacology in Drug Discovery and Development
  • Author : Terry Kenakin
  • Publisher : Academic Press
  • Release Date : 2016-10-21
  • Total pages : 350
  • ISBN : 0128037539
GET BOOK

Summary : Pharmacology in Drug Discovery and Development: Understanding Drug Response, Second Edition, is an introductory resource illustrating how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. The concepts discussed in this book ...

Drug Discovery and Evaluation Methods in Clinical Pharmacology

Drug Discovery and Evaluation  Methods in Clinical Pharmacology
  • Author : H.Gerhard Vogel,Jochen Maas,Alexander Gebauer
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-12-15
  • Total pages : 564
  • ISBN : 0128037539
GET BOOK

Summary : Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these ...

Molecular Pharmacology

Molecular Pharmacology
  • Author : John Dickenson,Fiona Freeman,Chris Lloyd Mills,Christian Thode,Shiva Sivasubramaniam
  • Publisher : John Wiley & Sons
  • Release Date : 2012-11-30
  • Total pages : 424
  • ISBN : 0128037539
GET BOOK

Summary : This textbook provides a fresh, comprehensive and accessible introduction to the rapidly expanding field of molecular pharmacology. Adopting a drug target-based, rather than the traditional organ/system based, approach this innovative guide reflects the current advances and research trend towards molecular based drug design, derived from a detailed understanding of ...

Quantitative Molecular Pharmacology and Informatics in Drug Discovery

Quantitative Molecular Pharmacology and Informatics in Drug Discovery
  • Author : Michael Lutz,Terry Kenakin
  • Publisher : John Wiley & Sons
  • Release Date : 2000-01-10
  • Total pages : 428
  • ISBN : 0128037539
GET BOOK

Summary : Quantitative Molecular Pharmacology and Informatics in Drug Discovery Michael Lutz, Section Head, Cheminformatics Group and Terry Kenakin, Principal Research Scientist, Glaxo Wellcome Research and Development, Research Triangle Park, NC, USA Quantitative Molecular Pharmacology and Informatics in Drug Discovery combines pharmacology, genetics and statistics to provide a complete guide to the ...

Drug Discovery and Evaluation Pharmacological Assays

Drug Discovery and Evaluation  Pharmacological Assays
  • Author : Hans G. Vogel
  • Publisher : Springer Science & Business Media
  • Release Date : 2002-06-13
  • Total pages : 1408
  • ISBN : 0128037539
GET BOOK

Summary : Now expanded and updated to include molecular biology and genetic engineering techniques. The second edition of this successful reference book contains a comprehensive selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Each of the more than 1000 assays comprises a detailed protocol outlining ...

Pharmacology for Chemists

Pharmacology for Chemists
  • Author : Raymond Hill,Terry Kenakin,Tom Blackburn
  • Publisher : Royal Society of Chemistry
  • Release Date : 2017-10-30
  • Total pages : 524
  • ISBN : 0128037539
GET BOOK

Summary : Download or read online Pharmacology for Chemists written by Raymond Hill,Terry Kenakin,Tom Blackburn, published by Royal Society of Chemistry which was released on 2017-10-30. Get Pharmacology for Chemists Books now! Available in PDF, ePub and Kindle....

Issues in Pharmacology Pharmacy Drug Research and Drug Innovation 2012 Edition

Issues in Pharmacology  Pharmacy  Drug Research  and Drug Innovation  2012 Edition
  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release Date : 2013-01-10
  • Total pages : 617
  • ISBN : 0128037539
GET BOOK

Summary : Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Molecular Pharmacology. The editors have built Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information ...

Drug Discovery and Evaluation

Drug Discovery and Evaluation
  • Author : Hans G. Vogel,Wolfgang H. Vogel
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-04-17
  • Total pages : 759
  • ISBN : 0128037539
GET BOOK

Summary : This reference book contains a comprehensive selection of the most frequently used assays for reliably detecting pharmacological effects of potential drugs, including tests for cardiovascular, analgesic, psychotropic, metabolic, endocrine, respiratory, renal, and immunomodulatory activities. Each of the over 700 assays comprises a detailed protocol with the purpose and rationale of the ...

Drug Discovery and Development E Book

Drug Discovery and Development   E Book
  • Author : Raymond G Hill
  • Publisher : Elsevier Health Sciences
  • Release Date : 2012-07-20
  • Total pages : 368
  • ISBN : 0128037539
GET BOOK

Summary : The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from ...

Modern Methods of Drug Discovery

Modern Methods of Drug Discovery
  • Author : Alexander Hillisch,Rolf Hilgenfeld
  • Publisher : Birkhäuser
  • Release Date : 2012-11-28
  • Total pages : 292
  • ISBN : 0128037539
GET BOOK

Summary : Research in the pharmaceutical industry today is in many respects quite different from what it used to be only fifteen years ago. There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity. While chemical modification of existing leads was the most important approach ...

Drug Discovery and Development Third Edition

Drug Discovery and Development  Third Edition
  • Author : James J. O'Donnell,John Somberg,Vincent Idemyor,James T. O'Donnell
  • Publisher : CRC Press
  • Release Date : 2019-11-21
  • Total pages : 668
  • ISBN : 0128037539
GET BOOK

Summary : Drug Discovery and Development, Third Edition presents up-to-date scientific information for maximizing the ability of a multidisciplinary research team to discover and bring new drugs to the marketplace. It explores many scientific advances in new drug discovery and development for areas such as screening technologies, biotechnology approaches, and evaluation of ...

New Approaches to Drug Discovery

New Approaches to Drug Discovery
  • Author : Ulrich Nielsch,Ulrike Fuhrmann,Stefan Jaroch
  • Publisher : Springer
  • Release Date : 2018-04-25
  • Total pages : 341
  • ISBN : 0128037539
GET BOOK

Summary : This volume gives an overview of state of the art technologies and future developments in the field of preclinical pharmaceutical research. A balanced mix of experts from academia and industry give insight in selected new developments in the drug discovery pathway. The topics cover the different parts of the drug ...

The Science and Business of Drug Discovery

The Science and Business of Drug Discovery
  • Author : Edward D. Zanders
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-07-08
  • Total pages : 397
  • ISBN : 0128037539
GET BOOK

Summary : The Science and Business of Drug Discovery is written for those who want to learn about the biopharmaceutical industry and its products whatever their level of technical knowledge. Its aim is to demystify the jargon used in drug development, but in a way that avoids over simplification and the resulting ...

A Pharmacology Primer

A Pharmacology Primer
  • Author : Terry Kenakin
  • Publisher : Academic Press
  • Release Date : 2018-10-26
  • Total pages : 488
  • ISBN : 0128037539
GET BOOK

Summary : A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Fifth Edition features the latest ideas and research regarding the application of pharmacology to the process of drug discovery. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. ...

Drug Discovery and Clinical Research

Drug Discovery and Clinical Research
  • Author : SK Gupta
  • Publisher : JP Medical Ltd
  • Release Date : 2011-06-01
  • Total pages : 668
  • ISBN : 0128037539
GET BOOK

Summary : The Drug Discovery and Clinical Research bandwagon has been joined by scientists and researchers from all fields including basic sciences, medical sciences, biophysicists, biotechnologists, statisticians, regulatory officials and many more. The joint effort and contribution from all is translating into the fast development of this multi-faceted field. At the same ...