Overcoming Cancers Resistant to Her 2 Antibodies

Written By Benjamin Bonavida
Overcoming Cancers Resistant to Her 2 Antibodies
  • Publsiher : Sensitizing Agents for Cancer
  • Release : 15 December 2019
  • ISBN : 9780128164082
  • Pages : 250 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Overcoming Cancers Resistant to Her 2 Antibodies written by Benjamin Bonavida which was release on 15 December 2019, this book published by Sensitizing Agents for Cancer. Available in PDF, EPUB and Kindle Format. Book excerpt: Overcoming Cancers Resistant to HER-2 Antibodies provides general updated information on the resistance of various human cancers to anti-HER2 therapeutic antibodies. It also discusses the description of various sensitizing agents that can reverse resistance when used in combination with anti-HER2 antibodies.There have been a lot of reports in which the treatment with anti-HER2 antibodies for various cancers has resulted in clinical responses; however, there have been also subsets of cancer patients who did not respond initially, and several responding patients developed resistance following treatments. Therefore, the use of various immunosensitizing agents to reverse resistance has been considered and this book discusses each of them in depth, such as Lapatinib, Ganetespib, Paclitaxel, Celecoxib, Emantasine, Liposomal Doxorubicin, and Kinase Inhibitors. This book is a valuable source for cancer researchers, oncologists, pharmacologists and different members of biomedical field interested in fighting cancer resistance to HER-2 antibodies. Provides a general summary of various sensitizing agents that can work effectively when used in combination with anti-HER2 antibodies to reverse resistance Offers potential underlying mechanisms by which the cancer cells are either inherently resistant or become unresponsive to antibody treatment Discusses how to develop new targeted agents to underlie resistance in order to expand research on this field

Overcoming Cancers Resistant to Her 2 Antibodies

Overcoming Cancers Resistant to Her 2 Antibodies
  • Author : Benjamin Bonavida
  • Publisher : Sensitizing Agents for Cancer
  • Release Date : 2019-12-15
  • Total pages : 250
  • ISBN : 9780128164082
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Summary : Overcoming Cancers Resistant to HER-2 Antibodies provides general updated information on the resistance of various human cancers to anti-HER2 therapeutic antibodies. It also discusses the description of various sensitizing agents that can reverse resistance when used in combination with anti-HER2 antibodies.There have been a lot of reports in which ...

Current Applications for Overcoming Resistance to Targeted Therapies

Current Applications for Overcoming Resistance to Targeted Therapies
  • Author : Myron R. Szewczuk,Bessi Qorri,Manpreet Sambi
  • Publisher : Springer
  • Release Date : 2019-07-15
  • Total pages : 320
  • ISBN : 9780128164082
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Summary : Targeted therapies were initially developed to exploit the upregulation and dependence on key oncogenic pathways critical to cancer progression. Additionally, they also presented as a method to overcome chemoresistance by supplementing conventional therapeutic regimens with targeted therapies. However, the development of resistance to these combinatorial approaches has led to the ...

Resistance to Immunotherapeutic Antibodies in Cancer

Resistance to Immunotherapeutic Antibodies in Cancer
  • Author : Benjamin Bonavida
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-08-04
  • Total pages : 202
  • ISBN : 9780128164082
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Summary : ​​​​The traditional approaches to treat various cancers include chemotherapy, radiation and/or hormonal therapy. While these therapies continue to be effective in large part, they are not selective and highly toxic. There have been encouraging results in alternative therapeutic approach called antibody-mediated anti-cancer therapy, which is less toxic, more selective, ...

Cancer Chemotherapy and Biotherapy

Cancer Chemotherapy and Biotherapy
  • Author : Bruce A. Chabner,Dan L. Longo
  • Publisher : Lippincott Williams & Wilkins
  • Release Date : 2011-12-07
  • Total pages : 848
  • ISBN : 9780128164082
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Summary : Updated to include the newest drugs and those currently in development, this Fifth Edition is a comprehensive reference on the preclinical and clinical pharmacology of anticancer agents. Organized by drug class, the book provides the latest information on all drugs and biological agents—their mechanisms of action, interactions with other ...

Investigating Novel Therapies for Breast Cancers Resistant to Trastuzumab

Investigating Novel Therapies for Breast Cancers Resistant to Trastuzumab
  • Author : Banujan Balachandran
  • Publisher : Unknown
  • Release Date : 2013
  • Total pages : 212
  • ISBN : 9780128164082
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Summary : "Approximately 20% of all metastatic breast cancers overexpress the HER-2 receptor, a cell surface-bound receptor tyrosine kinase upstream of crucial proliferation and cell survival pathways. Trastuzumab, a humanized monoclonal antibody binding to the extracellular domain of HER-2, has proven to be a beneficial treatment for patients diagnosed as HER-2+ but continues ...

PDK 1 Akt Pathway as Targets for Chemosensitizing Effects

PDK 1 Akt Pathway as Targets for Chemosensitizing Effects
  • Author : Ping-Hui Tseng
  • Publisher : Unknown
  • Release Date : 2005
  • Total pages : 116
  • ISBN : 9780128164082
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Summary : Abstract: Cancer is the leading causes of human deaths all over the world. The growing understanding in cancer biology provides the researchers to develop molecularly targeted therapeutic strategies. However, the toxicity and resistance limit the applications for molecularly targeted agents. Here, we proposed that inhibiting PI3K/PDK-1/Akt signaling ...

Translational Research in Breast Cancer

Translational Research in Breast Cancer
  • Author : Dong-Young Noh
  • Publisher : Springer Nature
  • Release Date : 2021-11-30
  • Total pages : 212
  • ISBN : 9780128164082
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Summary : Download or read online Translational Research in Breast Cancer written by Dong-Young Noh, published by Springer Nature which was released on . Get Translational Research in Breast Cancer Books now! Available in PDF, ePub and Kindle....

Monoclonal Antibodies Advances in Research and Application 2012 Edition

Monoclonal Antibodies   Advances in Research and Application  2012 Edition
  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release Date : 2012-12-26
  • Total pages : 105
  • ISBN : 9780128164082
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Summary : Monoclonal Antibodies—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Monoclonal Antibodies. The editors have built Monoclonal Antibodies—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Monoclonal Antibodies in ...

Cancer Cell Signaling

Cancer Cell Signaling
  • Author : Kasirajan Ayyanathan
  • Publisher : CRC Press
  • Release Date : 2014-06-20
  • Total pages : 410
  • ISBN : 9780128164082
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Summary : This title includes a number of Open Access chapters. Cell signaling is a field that studies how cells communicate to control basic activities and respond to their environment. When looking specifically at cancer cells, researchers can gain a better understanding of cancer on a cellular level, an understanding that may ...

Overcoming Ovarian Cancer Chemoresistance

Overcoming Ovarian Cancer Chemoresistance
  • Author : Goli Samimi,Christina Annunziata
  • Publisher : Academic Press
  • Release Date : 2020-11-06
  • Total pages : 188
  • ISBN : 9780128164082
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Summary : Overcoming Ovarian Cancer Chemoresistance presents non-overlapping review chapters that discuss the state of the field in overcoming chemoresistance of ovarian cancer and treatment options before and following recurrence, considering the genetic makeup of the ovarian cancer patient and her tumor. With the uptake of both germline and somatic gene testing, ...

Translational Medicine

Translational Medicine
  • Author : Robert A. Meyers
  • Publisher : John Wiley & Sons
  • Release Date : 2016-04-29
  • Total pages : 940
  • ISBN : 9780128164082
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Summary : The first complete overview of progress in the field. The two volumes contain selected articles from the prestigious online Encyclopedia of Molecular Cell Biology and Molecular Medicine, fully updated and enriched with numerous new contributions from many eminent scientists. Divided into three parts, the first gives a thorough introduction to ...

Handbook of HER2 targeted agents in breast cancer

Handbook of HER2 targeted agents in breast cancer
  • Author : Ricardo H Alvarez,Javier Cortés,Leticia Mattos-Arruda,Mary Falzon,Angelica Fasolo,Michael Gandy,Luca Gianni,Nadia Harbeck,Martine Piccart,Stefania Zambelli,Dimitrios Zardavas
  • Publisher : Springer
  • Release Date : 2014-05-28
  • Total pages : 96
  • ISBN : 9780128164082
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Summary : ​Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in women worldwide, accounting for nearly a quarter of the total new cancer cases each year. Of these cases, approximately 15–25% overexpress HER2, a transmembrane RTK kinase that is associated with aggressive tumor growth and poor ...

Resistance to Targeted Therapies in Breast Cancer

Resistance to Targeted Therapies in Breast Cancer
  • Author : Jenifer R. Prosperi
  • Publisher : Springer
  • Release Date : 2017-12-04
  • Total pages : 184
  • ISBN : 9780128164082
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Summary : We present an in-depth description of resistance to targeted therapies in breast cancer. Targeted therapies discussed here include those used to treat ER+ or Her2+ breast cancers (i.e., Tamoxifen or trastuzumab) or those targeting signaling pathways aberrantly activated in triple negative breast cancer (i.e., EGFR and Wnt signaling). ...

Targeted Cancer Therapies From Small Molecules to Antibodies

Targeted Cancer Therapies  From Small Molecules to Antibodies
  • Author : Zhe-Sheng Chen,Jian-ye Zhang,Yunkai Zhang,Yan-yan Yan
  • Publisher : Frontiers Media SA
  • Release Date : 2020-07-22
  • Total pages : 212
  • ISBN : 9780128164082
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Summary : Download or read online Targeted Cancer Therapies From Small Molecules to Antibodies written by Zhe-Sheng Chen,Jian-ye Zhang,Yunkai Zhang,Yan-yan Yan, published by Frontiers Media SA which was released on 2020-07-22. Get Targeted Cancer Therapies From Small Molecules to Antibodies Books now! Available in PDF, ePub and Kindle....

Breast Cancer

Breast Cancer
  • Author : Mehmet Gunduz,Esra Gunduz
  • Publisher : BoD – Books on Demand
  • Release Date : 2011-11-30
  • Total pages : 746
  • ISBN : 9780128164082
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Summary : Cancer is the leading cause of death in most countries and its consequences result in huge economic, social and psychological burden. Breast cancer is the most frequently diagnosed cancer type and the leading cause of cancer death among females. In this book, we discussed various aspects of breast cancer carcinogenesis ...