Ocular Transporters and Receptors

Written By Ashim K Mitra
Ocular Transporters and Receptors
  • Publsiher : Elsevier
  • Release : 31 October 2013
  • ISBN : 190881831X
  • Pages : 276 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Ocular Transporters and Receptors written by Ashim K Mitra which was release on 31 October 2013, this book published by Elsevier. Available in PDF, EPUB and Kindle Format. Book excerpt: Ocular transporters and receptors contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. The complex anatomy and the existence of multiple barriers in the eye pose a considerable challenge to successful drug delivery to the eye. Hence ocular transporters and receptors are important targets for drug delivery. A significant advancement has been made in the field of ocular transport research and their role in drug delivery. In this book the cutting edge research being carried out in this field is compiled and summarized. The book focuses on key areas, including the anatomy and physiology of the eye, biology of ocular transporters and receptors, techniques in characterization of transporters and receptors, transporters and receptors in the anterior and posterior segment in the eye, the role of ocular transporters and receptors in drug delivery, and transporter-metabolism interplay in the eye. Highly focused on ocular transporters Most up-to-date research compilation Detailed description of role of transporters and receptors in ocular drug discovery and delivery

Ocular Transporters and Receptors

Ocular Transporters and Receptors
  • Author : Ashim K Mitra
  • Publisher : Elsevier
  • Release Date : 2013-10-31
  • Total pages : 276
  • ISBN : 190881831X
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Summary : Ocular transporters and receptors contains detailed descriptions of major transporters and receptors expressed in the eye, with special emphasis on their role in drug delivery. The complex anatomy and the existence of multiple barriers in the eye pose a considerable challenge to successful drug delivery to the eye. Hence ocular ...

Ocular Transporters in Ophthalmic Diseases and Drug Delivery

Ocular Transporters in Ophthalmic Diseases and Drug Delivery
  • Author : Joyce Tombran-Tink,Colin J. Barnstable
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-04-09
  • Total pages : 467
  • ISBN : 190881831X
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Summary : In this exceptionally important new work, a panel of distinguished authors discusses all the latest developments in the study of ocular transporters. Focusing on the molecular characteristics, localization, and substrate specificities in various compartments of the eye, this volume discusses how transporters regulate the clarity of the cornea and lens, ...

Prodrugs and Targeted Delivery

Prodrugs and Targeted Delivery
  • Author : Jarkko Rautio
  • Publisher : John Wiley & Sons
  • Release Date : 2011-01-11
  • Total pages : 520
  • ISBN : 190881831X
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Summary : This topical reference and handbook addresses the chemistry, pharmacology, toxicology and the patentability of prodrugs, perfectly mirroring the integrated approach prevalent in today's drug design. It summarizes current experiences and strategies for the rational design of prodrugs, beginning at the early stages of the development process, as well as discussing ...

The Biology of the Eye

The Biology of the Eye
  • Author : Jorge Fischbarg
  • Publisher : Elsevier
  • Release Date : 2005-12-09
  • Total pages : 406
  • ISBN : 190881831X
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Summary : Acknowledgement This book is the result of a collective effort. Due to an oversight, mention of three of the contributors who played an especially decisive role in bringing the work to fruition was omitted from the book. They should share fully in the intellectual credits accruing from this publication. I ...

Transporters in Drug Discovery and Development

Transporters in Drug Discovery and Development
  • Author : Yurong Lai
  • Publisher : Woodhead Publishing
  • Release Date : 2014-08-22
  • Total pages : 780
  • ISBN : 190881831X
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Summary : Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant ...

Pharmacology of Ocular Therapeutics

Pharmacology of Ocular Therapeutics
  • Author : Thirumurthy Velpandian
  • Publisher : Springer
  • Release Date : 2016-02-29
  • Total pages : 535
  • ISBN : 190881831X
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Summary : This book comprises an integrated review of ocular therapeutics across all relevant fields. It addresses the real-world requirements of ophthalmologists, pharmacists and optometrists, as observed through working alongside these practitioners for two decades. Knowledge surrounding agents used in ophthalmic practice has, historically, been scattered. The book facilitates understanding of ocular ...

Drug Delivery Research Advances

Drug Delivery Research Advances
  • Author : Boris O. Mashkevich
  • Publisher : Nova Publishers
  • Release Date : 2007
  • Total pages : 259
  • ISBN : 190881831X
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Summary : Drug delivery is a term that refers to the delivery of a pharmaceutical compound to humans or animals. Most common methods of delivery include the preferred non-invasive oral (through the mouth), nasal, pneumonial (inhalation), and rectal routes. Many medications, however, can not be delivered using these routes because they might ...

Design of Amino Acid Prodrugs of Acyclovir for Improved Bioavailability and Therapeutic Activity

Design of Amino Acid Prodrugs of Acyclovir for Improved Bioavailability and Therapeutic Activity
  • Author : Suresh Katragadda,Ashim K. Mitra
  • Publisher : Unknown
  • Release Date : 2007
  • Total pages : 366
  • ISBN : 190881831X
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Summary : Infection with herpes simplex virus is the single most frequent cause of corneal opacities in developed countries. Currently available therapy for HSV keratitis involves the use of trifluorothymidine, idoxuridine and vidarabine. However, one of major problems associated with these drugs is their poor ocular absorption and cytotoxicity restricting their use ...

Polysaccharide Carriers for Drug Delivery

Polysaccharide Carriers for Drug Delivery
  • Author : Sabyasachi Maiti,Sougata Jana
  • Publisher : Woodhead Publishing
  • Release Date : 2019-06-14
  • Total pages : 802
  • ISBN : 190881831X
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Summary : Polysaccharide Carriers for Drug Delivery presents the latest information on the selection of safe materials. Due to reported safety profiles on polysaccharides; they have been the natural choice for investigation. A wide variety of drug delivery and biomedical systems have been studied, however, the related information either concept-wise or application-oriented ...

Chitin Chitosan

Chitin Chitosan
  • Author : Rajendra Dongre
  • Publisher : BoD – Books on Demand
  • Release Date : 2018-07-18
  • Total pages : 382
  • ISBN : 190881831X
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Summary : Chitin is the second most abundant biopolymer after cellulose and is a resourceful copious and cheap biomaterial discovered in 1859 owing to significant industrial and technological utility. Raw chitin-chitosan resembles keratin in its biological functions. Chitin chemistry vastly developed via innate unparalleled biological features and exceptional physicochemical characters. Chitosan endures assorted ...

Peptide and Protein Delivery

Peptide and Protein Delivery
  • Author : Chris Van Der Walle
  • Publisher : Academic Press
  • Release Date : 2011-05-12
  • Total pages : 380
  • ISBN : 190881831X
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Summary : The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary ...

Design of Prodrugs of Acyclovir for Ocular Oral and Genital Herpes Virus Infections Targeting the Oligopeptide and Amino Acid Transporter on the Cornea and Intestine for Improved Bioavailability Safety and Therapeutic Activity

Design of Prodrugs of Acyclovir for Ocular  Oral and Genital Herpes Virus Infections  Targeting the Oligopeptide and Amino Acid Transporter on the Cornea and Intestine for Improved Bioavailability  Safety and Therapeutic Activity
  • Author : Banmeet Singh Anand
  • Publisher : Unknown
  • Release Date : 2004
  • Total pages : 260
  • ISBN : 190881831X
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Summary : Recently significant amount of work has been reported on substrate specificities of membrane transporters and receptors leading to successful design of prodrugs targeted to them for improved efficacy and absorption. VACV is such a prodrug that is recognized by the peptide transporter, hPEPT1 resulting in enhancement of oral bioavailability of ...

Mucosal Delivery of Drugs and Biologics in Nanoparticles

Mucosal Delivery of Drugs and Biologics in Nanoparticles
  • Author : Pavan Muttil,Nitesh K. Kunda
  • Publisher : Springer Nature
  • Release Date : 2020-03-18
  • Total pages : 277
  • ISBN : 190881831X
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Summary : Nanotechnology has revolutionized the approach to designing and developing novel drug delivery systems. The last two decades have seen a great interest in the use of nanotechnology to offer efficient ways of delivering new and existing drugs and macromolecules. The focus of this book is the application of nanotechnology to ...

Drug Delivery for the Retina and Posterior Segment Disease

Drug Delivery for the Retina and Posterior Segment Disease
  • Author : Jayvadan K. Patel,Vijaykumar Sutariya,Jagat Rakesh Kanwar,Yashwant V. Pathak
  • Publisher : Springer
  • Release Date : 2018-10-08
  • Total pages : 494
  • ISBN : 190881831X
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Summary : This book addresses the issues relating to a wide variety of ocular diseases from which millions of people suffer. Long-term challenges include visual impairment and ocular blindness. Certain ocular diseases are quite rare, whereas others, such as cataracts, age-related macular degeneration (AMD), and glaucoma, are very common, especially in the ...

Ocular Periphery and Disorders

Ocular Periphery and Disorders
  • Author : Darlene A. Dartt,Peter Bex,Patricia D'Amore
  • Publisher : Academic Press
  • Release Date : 2011
  • Total pages : 553
  • ISBN : 190881831X
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Summary : This selection of articles from the Encyclopedia of the Eye is the first single-volume overview presenting articles on the function, biology, physiology, and pathology of the structures of the ocular periphery, as well as the related disorders and their treatment. The peripheral structures are implicated in a number of important ...