Novel Designs of Early Phase Trials for Cancer Therapeutics

Written By Shivaani Kummar
Novel Designs of Early Phase Trials for Cancer Therapeutics
  • Publsiher : Academic Press
  • Release : 22 May 2018
  • ISBN : 0128125705
  • Pages : 234 pages
  • Rating : 4/5 from 21 reviews
GET THIS BOOKNovel Designs of Early Phase Trials for Cancer Therapeutics


Read or download book entitled Novel Designs of Early Phase Trials for Cancer Therapeutics written by Shivaani Kummar which was release on 22 May 2018, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: Novel Designs of Early Phase Trials for Cancer Therapeutics provides a comprehensive review by leaders in the field of the process of drug development, the integration of molecular profiling, the changes in early phase trial designs, and endpoints to optimally develop a new generation of cancer therapeutics. The book discusses topics such as statistical perspectives on cohort expansions, the role and application of molecular profiling and how to integrate biomarkers in early phase trials. Additionally, it discusses how to incorporate patient reported outcomes in phase one trials. This book is a valuable resource for medical oncologists, basic and translational biomedical scientists, and trainees in oncology and pharmacology who are interested in learning how to improve their research by using early phase trials. Brings a comprehensive review and recommendations for new clinical trial designs for modern cancer therapeutics Provides the reader with a better understanding on how to design and implement early phase oncology trials Presents a better and updated understanding of the process of developing new treatments for cancer, the exciting scientific advances and how they are informing drug development

Novel Designs of Early Phase Trials for Cancer Therapeutics

Novel Designs of Early Phase Trials for Cancer Therapeutics
  • Author : Shivaani Kummar,Chris Takimoto
  • Publisher : Academic Press
  • Release Date : 2018-05-22
  • Total pages : 234
  • ISBN : 0128125705
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Summary : Novel Designs of Early Phase Trials for Cancer Therapeutics provides a comprehensive review by leaders in the field of the process of drug development, the integration of molecular profiling, the changes in early phase trial designs, and endpoints to optimally develop a new generation of cancer therapeutics. The book discusses ...

Biomarkers of the Tumor Microenvironment

Biomarkers of the Tumor Microenvironment
  • Author : Lars A. Akslen,Randolph S. Watnick
  • Publisher : Springer
  • Release Date : 2017-08-02
  • Total pages : 534
  • ISBN : 0128125705
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Summary : This book reviews different aspects of the cancer microenvironment, and its regulation and importance for tumor progression. Practical applications, in terms of how biomarkers are increasingly included in therapy protocols, will also be discussed. Biomarkers of the Tumour Microenvironment: Basic Studies and Practical Applications is aimed at research pathologists in ...

Phase I Oncology Drug Development

Phase I Oncology Drug Development
  • Author : Timothy A. Yap,Jordi Rodon,David S. Hong
  • Publisher : Springer
  • Release Date : 2020-10-07
  • Total pages : 352
  • ISBN : 0128125705
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Summary : This book provides a detailed review of how oncology drug development has changed over the past decade, and serves as a comprehensive guide for the practicalities in setting up phase I trials. The book covers strategies to accelerate the development of novel antitumor compounds from the laboratory to clinical trials ...

Statistical Approaches in Oncology Clinical Development

Statistical Approaches in Oncology Clinical Development
  • Author : Satrajit Roychoudhury,Soumi Lahiri
  • Publisher : CRC Press
  • Release Date : 2018-12-07
  • Total pages : 220
  • ISBN : 0128125705
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Summary : Statistical Approaches in Oncology Clinical Development : Current Paradigm and Methodological Advancement presents an overview of statistical considerations in oncology clinical trials, both early and late phase of development. It illustrates how novel statistical methods can enrich the design and analysis of modern oncology trials. The authors include many relevant real ...

Oncology Clinical Trials

Oncology Clinical Trials
  • Author : Susan Halabi, PhD,Wm. Kevin Kelly, DO
  • Publisher : Demos Medical Publishing
  • Release Date : 2009-12-22
  • Total pages : 168
  • ISBN : 0128125705
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Summary : Clinical trials are the engine of progress in the development of new drugs and devices for the detection, monitoring, prevention and treatment of cancer. A well conceived, carefully designed and efficiently conducted clinical trial can produce results that change clinical practice overnight, deliver new oncology drugs and diagnostics to the ...

Journal of the National Cancer Institute

Journal of the National Cancer Institute
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2004
  • Total pages : 212
  • ISBN : 0128125705
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Summary : "Summaries of papers" contained in the journal accompany each issue, 19--...

Phase I Cancer Clinical Trials

Phase I Cancer Clinical Trials
  • Author : Chris Twelves,Marc E. Buyse
  • Publisher : Oxford University Press, USA
  • Release Date : 2014-06-01
  • Total pages : 368
  • ISBN : 0128125705
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Summary : Preceded by Phase I cancer clinical trials: a practical guide / Elizabeth A. Eisenhauer, Christopher Twelves, Marc Buyse. 1st ed. 2006....

The Journal of Alternative and Complementary Medicine

The Journal of Alternative and Complementary Medicine
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2007
  • Total pages : 212
  • ISBN : 0128125705
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Summary : Download or read online The Journal of Alternative and Complementary Medicine written by , published by which was released on 2007. Get The Journal of Alternative and Complementary Medicine Books now! Available in PDF, ePub and Kindle....

Designs for Clinical Trials

Designs for Clinical Trials
  • Author : David Harrington
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-10-09
  • Total pages : 206
  • ISBN : 0128125705
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Summary : This book will examine current issues and controversies in the design of clinical trials, including topics in adaptive and sequential designs, the design of correlative genomic studies, the design of studies in which missing data is anticipated. Each chapter will be written by an expert conducting research in the topic ...

A Practical Guide to Designing Phase II Trials in Oncology

A Practical Guide to Designing Phase II Trials in Oncology
  • Author : Sarah R. Brown,Walter M. Gregory,Christopher J. Twelves,Julia M. Brown
  • Publisher : John Wiley & Sons
  • Release Date : 2014-03-28
  • Total pages : 256
  • ISBN : 0128125705
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Summary : How to identify optimal phase II trial designs Providing a practical guide containing the information needed to make crucial decisions regarding phase II trial designs, A Practical Guide to Designing Phase II Trials in Oncology sets forth specific points for consideration between the statistician and clinician when designing a phase ...

Handbook of Statistics in Clinical Oncology Third Edition

Handbook of Statistics in Clinical Oncology  Third Edition
  • Author : John Crowley,Antje Hoering
  • Publisher : CRC Press
  • Release Date : 2012-03-26
  • Total pages : 657
  • ISBN : 0128125705
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Summary : Many new challenges have arisen in the area of oncology clinical trials. New cancer therapies are often based on cytostatic or targeted agents, which pose new challenges in the design and analysis of all phases of trials. The literature on adaptive trial designs and early stopping has been exploding. Inclusion ...

Anticancer Drug Development Guide

Anticancer Drug Development Guide
  • Author : Beverly A. Teicher,Paul A. Andrews
  • Publisher : Springer Science & Business Media
  • Release Date : 2004-02-01
  • Total pages : 451
  • ISBN : 0128125705
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Summary : This unique volume traces the critically important pathway by which a "molecule" becomes an "anticancer agent. " The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus ...

Research Report

Research Report
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1999
  • Total pages : 212
  • ISBN : 0128125705
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Summary : Download or read online Research Report written by , published by which was released on 1999. Get Research Report Books now! Available in PDF, ePub and Kindle....

Platform Trial Designs in Drug Development

Platform Trial Designs in Drug Development
  • Author : Zoran Antonijevic,Robert A. Beckman
  • Publisher : CRC Press
  • Release Date : 2018-12-07
  • Total pages : 304
  • ISBN : 0128125705
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Summary : Platform trials test multiple therapies in one indication, one therapy for multiple indications, or both. These novel clinical trial designs can dramatically increase the cost-effectiveness of drug development, leading to life-altering medicines for people suffering from serious illnesses, possibly at lower cost. Currently, the cost of drug development is unsustainable. ...

Oncology

Oncology
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2000
  • Total pages : 212
  • ISBN : 0128125705
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Summary : Download or read online Oncology written by , published by which was released on 2000. Get Oncology Books now! Available in PDF, ePub and Kindle....