NETosis At the Intersection of Cell Biology Microbiology and Immunology

Written By Mariana J. Kaplan
NETosis  At the Intersection of Cell Biology  Microbiology  and Immunology
  • Publsiher : Frontiers E-books
  • Release : 08 August 2013
  • ISBN : 2889191583
  • Pages : 212 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled NETosis At the Intersection of Cell Biology Microbiology and Immunology written by Mariana J. Kaplan which was release on 08 August 2013, this book published by Frontiers E-books. Available in PDF, EPUB and Kindle Format. Book excerpt: NETosis is a unique form of cell death that is characterized by the release of decondensed chromatin and granular contents to the extracellular space. The initial observation of NETosis placed the process within the context of the innate immune response to infections. Neutrophils, the most numerous leukocytes that arrive quickly at the site of an infection, were the first cell type shown to undergo extracellular trap formation. However, subsequent studies showed that other granulocytes are also capable of releasing nuclear chromatin following stimulation. The extracellular chromatin acts to immobilize microbes and prevent their dispersal in the host. Bacterial breakdown products and inflammatory stimuli induce NETosis and the release of NETs requires enzyme activities. Histones in NET chromatin become modified by peptidylarginine deiminase 4 (PAD4) and cleaved at specific sites by proteases. NETs serve for attachment of bactericidal enzymes including myeloperoxidase, leukocyte proteases, and the cathelicidin LL-37. While the benefit of NETs in an infection appears clear, NETs also figure prominently at the center of various pathologic states. Therefore, it is important for NETs to be efficiently cleared; else digestive enzymes may gain access to tissues where inflammation takes place. Persistent NET exposure at sites of inflammation may lead to a further complication: NET antigens may provoke acquired immune responses and, over time, could initiate autoimmune reactions. Recent studies identified aberrant NET synthesis and/or clearance in inflammatory/autoimmune conditions such as systemic lupus erythematosus (SLE), psoriasis, ANCA-positive vasculitis, gout and Felty’s syndrome. In the case of SLE, for example, it appears that LL-37 exposed in the NETs may be a significant trigger of type I Interferon responses in this disease. Recent evidence also implicates aberrant NET formation in the development of endothelial damage, atherosclerosis and thrombosis. NETosis is thus of interest to researchers who investigate innate immune responses, host-pathogen interactions, chronic inflammatory disorders, cell and vascular biology, biochemistry, and autoimmunity. As we approach the 10-year-anniversary of the initial discovery of NETosis, it is useful and timely to review the so far identified mechanisms and pathways of NET formation, their role in bacterial and fungal defense and their putative importance as inducers of autoimmune responses. We look forward to a rich and rigorous discussion of these and related issues that benefit from interdisciplinary approaches, collaborations and exciting discoveries.

NETosis At the Intersection of Cell Biology Microbiology and Immunology

NETosis  At the Intersection of Cell Biology  Microbiology  and Immunology
  • Author : Mariana J. Kaplan,Marko Radic
  • Publisher : Frontiers E-books
  • Release Date : 2013-08-08
  • Total pages : 212
  • ISBN : 2889191583
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Summary : NETosis is a unique form of cell death that is characterized by the release of decondensed chromatin and granular contents to the extracellular space. The initial observation of NETosis placed the process within the context of the innate immune response to infections. Neutrophils, the most numerous leukocytes that arrive quickly ...

NETosis

NETosis
  • Author : Geeta Rai
  • Publisher : Academic Press
  • Release Date : 2019-06-01
  • Total pages : 200
  • ISBN : 2889191583
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Summary : NETosis: Immunity, Pathogenesis and Therapeutics takes a focused approach to the clinical aspects of NETosis and drug development, bringing critical findings. Chapters introduce NETosis, consider mechanisms and antimicrobial strategies regulating NETosis, examine NETosis in neonates, explore the role of NETosis in autoimmunity, delve into NETosis and other diseases, and present ...

NETosis 2 The Excitement Continues

NETosis 2  The Excitement Continues
  • Author : Mariana J. Kaplan,Marko Radic,Martin Herrmann
  • Publisher : Frontiers Media SA
  • Release Date : 2017-12-28
  • Total pages : 212
  • ISBN : 2889191583
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Summary : NETosis, a form of cell death that manifests by the release of decondensed chromatin to the extracellular space, provides valuable insights into mechanisms and consequences of cellular demise. Because extracellular chromatin can immobilize microbes, the extended nucleohistone network was called a neutrophil extracellular trap (NET), and the process of chromatin ...

Oxford Textbook of Rheumatoid Arthritis

Oxford Textbook of Rheumatoid Arthritis
  • Author : David L. Scott,James Galloway,Andrew Cope,Vibeke Strand
  • Publisher : Oxford University Press, USA
  • Release Date : 2020-05-12
  • Total pages : 576
  • ISBN : 2889191583
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Summary : The Oxford Textbook of Rheumatoid Arthritis covers all relevant aspects of the fisease, ranging from basic science, epidemiology, clinical and laboratory assessments, drug and non-drug treatments, and disease outcomes. Written by an international team of experts, it will be an invaluable resource for those involved with people with RA....

Damage Associated Molecular Patterns in Human Diseases

Damage Associated Molecular Patterns in Human Diseases
  • Author : Walter Gottlieb Land
  • Publisher : Springer
  • Release Date : 2018-10-09
  • Total pages : 870
  • ISBN : 2889191583
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Summary : This book presents current understanding of the importance of modern immunology in the etiopathogenesis of human diseases and explores how this understanding is impacting on diagnosis, prognosis, treatment, and prophylaxis. As the core of modern immunology, the “danger/injury model” is introduced and addressed throughout the book. Volume I of ...

Physical Phenotyping of Neutrophil NETosis Using Fluorescence Imaging Deformability Cytometry

Physical Phenotyping of Neutrophil NETosis Using Fluorescence Imaging Deformability Cytometry
  • Author : Hector Enrique Munoz
  • Publisher : Unknown
  • Release Date : 2020
  • Total pages : 176
  • ISBN : 2889191583
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Summary : The cell mechanical phenotype is a useful measure to understand cell identity and state. Cell mechanical properties such as deformability can provide an understanding of cellular processes or intracellular composition without direct labeling. The cell nucleus is a significant component of the cell and it is useful to understand how ...

The Role of Galectin 3 mediated NETosis in Systemic Lupus Erythematosus

The Role of Galectin 3 mediated NETosis in Systemic Lupus Erythematosus
  • Author : 陳璟儀
  • Publisher : Unknown
  • Release Date : 2017
  • Total pages : 39
  • ISBN : 2889191583
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Summary : Download or read online The Role of Galectin 3 mediated NETosis in Systemic Lupus Erythematosus written by 陳璟儀, published by which was released on 2017. Get The Role of Galectin 3 mediated NETosis in Systemic Lupus Erythematosus Books now! Available in PDF, ePub and Kindle....

On the Role of Neutrophils and NETosis in Acute Pancreatitis

On the Role of Neutrophils and NETosis in Acute Pancreatitis
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2020
  • Total pages : 212
  • ISBN : 2889191583
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Summary : Download or read online On the Role of Neutrophils and NETosis in Acute Pancreatitis written by , published by which was released on 2020. Get On the Role of Neutrophils and NETosis in Acute Pancreatitis Books now! Available in PDF, ePub and Kindle....

Healthy and Beauty Finding of current life science experiment for human sustainability

Healthy and Beauty  Finding of current life science experiment for human sustainability
  • Author : Mohd Hilmi Abu Bakar
  • Publisher : GRIN Verlag
  • Release Date : 2019-08-08
  • Total pages : 27
  • ISBN : 2889191583
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Summary : Abstract from the year 2019 in the subject Medicine - Public Health, grade: 10.0, , language: English, abstract: This work is a collection of studies concerning human sustainability. We were proud for having Postgrad Colloquium 2019, Faculty of Health Sciences Universiti Sultan Zainal Abidin (UniSZA). It was held on 30th April 2019 at Academic Building ...

Role of Neutrophils in Inflammatory Diseases

Role of Neutrophils in Inflammatory Diseases
  • Author : Laurent Reber,Thomas Marichal,Onur Boyman
  • Publisher : Frontiers Media SA
  • Release Date : 2021-01-20
  • Total pages : 212
  • ISBN : 2889191583
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Summary : Download or read online Role of Neutrophils in Inflammatory Diseases written by Laurent Reber,Thomas Marichal,Onur Boyman, published by Frontiers Media SA which was released on 2021-01-20. Get Role of Neutrophils in Inflammatory Diseases Books now! Available in PDF, ePub and Kindle....

Dermatopathology Fourth Edition

Dermatopathology  Fourth Edition
  • Author : Raymond L. Barnhill,A. Neil Crowson,Cynthia M. Magro,Michael W. Piepkorn
  • Publisher : McGraw Hill Professional
  • Release Date : 2019-06-22
  • Total pages : 1568
  • ISBN : 2889191583
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Summary : The definitive survey of diagnostic dermatopathology—and the single-best resource for addressing differential diagnosis at the microscopic level For virtually every kind of skin lesion, this skill-sharpening resource has everything clinicians need to successfully perform differential diagnosis at the microscopic level. Dermatopathology features a systematic, algorithmic approach that cuts through ...

Williams Hematology 9E

Williams Hematology  9E
  • Author : Kenneth Kaushansky,Marshall A. Lichtman,Josef Prchal,Marcel M. Levi,Oliver W Press,Linda J Burns,Michael Caligiuri
  • Publisher : McGraw Hill Professional
  • Release Date : 2015-12-23
  • Total pages : 2528
  • ISBN : 2889191583
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Summary : Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The world's most highly regarded reference text on the mechanisms and clinical management of blood diseases A Doody's Core Title for 2019! Edition after ...

Pathology A Modern Case Study

Pathology  A Modern Case Study
  • Author : Howard Reisner
  • Publisher : McGraw Hill Professional
  • Release Date : 2014-09-22
  • Total pages : 672
  • ISBN : 2889191583
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Summary : A unique case-based molecular approach to understanding pathology Pathology: A Modern Case Study is a concise, focused text that emphasizes the molecular and cellular biology essential to understanding the concepts of disease causation. The book includes numerous case studies designed to highlight the role of the pathologist in the team ...

Role of Neutrophils in Disease Pathogenesis

Role of Neutrophils in Disease Pathogenesis
  • Author : Maitham Khajah
  • Publisher : BoD – Books on Demand
  • Release Date : 2017-06-07
  • Total pages : 180
  • ISBN : 2889191583
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Summary : This book highlights the important role of neutrophils in health as well as in the pathogenesis of various diseases. Section 1 provides a general background information regarding the mechanisms and various triggers of neutrophil extracellular traps (NETs) formation and their role in various infectious and noninfectious diseases (such as postinjury inflammation). ...

The Role of Flagellar Motility in Pseudomonas Aeruginosa induced Formation of Neutrophil Extracellular Traps NETs

The Role of Flagellar Motility in Pseudomonas Aeruginosa induced Formation of Neutrophil Extracellular Traps  NETs
  • Author : Madison Shea Floyd
  • Publisher : Unknown
  • Release Date : 2015
  • Total pages : 156
  • ISBN : 2889191583
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Summary : Cystic fibrosis (CF) is a primarily pulmonary disease characterized by impaired mucociliary clearance and chronic bacterial infections. Pseudomonas aeruginosa is the main CF pathogen responsible for large-scale neutrophil recruitment in the airways. When neutrophils fail to clear bacteria, P. aeruginosa-induced neutrophil extracellular traps (NETs) likely form, during which neutrophil granulocytes ...