Introduction to Biological and Small Molecule Drug Research and Development

Written By C. Robin Ganellin
Introduction to Biological and Small Molecule Drug Research and Development
  • Publsiher : Academic Press
  • Release : 07 May 2013
  • ISBN : 0123977703
  • Pages : 472 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Introduction to Biological and Small Molecule Drug Research and Development written by C. Robin Ganellin which was release on 07 May 2013, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the business and management issues of these approaches. The latter part of the book provides carefully selected real-life case studies illustrating how the theory presented in the first part of the book is actually put into practice. Studies include Herceptin/T-DM1, erythropoietin (Epogen/Eprex/NeoRecormon), anti-HIV protease inhibitor Darunavir, and more. Introduction to Biological and Small Molecule Drug Research and Development is intended for late-stage undergraduates or postgraduates studying chemistry (at the biology interface), biochemistry, medicine, pharmacy, medicine, or allied subjects. The book is also useful in a wide variety of science degree courses, in post-graduate taught material (Masters and PhD), and as basic background reading for scientists in the pharmaceutical industry. For the first time, the fundamental scientific principles of biopharmaceuticals and small molecule chemotherapeutics are discussed side-by-side at a basic level Edited by three senior scientists with over 100 years of experience in drug research who have compiled the best scientific comparison of small molecule and biopharmaceuticals approaches to new drugs Illustrated with key examples of important drugs that exemplify the basic principles of pharmaceutical drug research and development

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : C. Robin Ganellin,Roy Jefferis,Stanley M. Roberts
  • Publisher : Academic Press
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 0123977703
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Summary : Introduction to Biological and Small Molecule Drug Research and Development provides, for the first time, an introduction to the science behind successful pharmaceutical research and development programs. The book explains basic principles, then compares and contrasts approaches to both biopharmaceuticals (proteins) and small molecule drugs, presenting an overview of the ...

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : James Samanen
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 0123977703
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Summary : Biotechnology has given rise to a broad range of biotherapies or biologics, including biomolecular drugs, vaccines, cell or gene therapies. This chapter focuses on biomolecular drugs, namely monoclonal antibodies (Mabs), cytokines, tissue growth factors and therapeutic proteins. Prior to the US approval of recombinant human insulin in 1982, biomolecular drugs were ...

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : Michael Stocks
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 0123977703
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Summary : Drug discovery of small molecules from target selection through to clinical evaluation is a very complex, challenging but rewarding area of drug discovery. There are many obstacles along the journey from initial hit-finding activities, through optimization of compounds and eventually to delivery of robust candidate drugs (CDs) for clinical evaluation. ...

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : Jill M. Carton,William R. Strohl
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 0123977703
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Summary : Throughout human history, the morbidity and mortality associated with human disease has driven medical science into an ever-expanding quest for treatment and cure. Over the past century, a therapeutic approach complementing chemical drugs has been developing which uses proteins and peptides in the treatment of disease. Many innovative protein therapeutic ...

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : James Samanen
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 0123977703
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Summary : Successful drugs have a good return on investment by bringing in considerably more revenue than the expenses of discovery, development, and manufacturing. Successful drugs pay for all drug projects, those that fail and those that have yet to fail or succeed. Most research and development (R&D) projects fail. Since ...

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : Matthew P. Coghlan,David Fairman
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 0123977703
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Summary : The increasing global prevalence of type 2 diabetes represents a significant burden of disease for afflicted patients and for health care systems. In the developed world poorly controlled diabetes is the leading cause of non-traumatic amputation, blindness and end-stage renal disease requiring dialysis and kidney transplant. Additionally, diabetes represents a significant ...

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : Andy Barker,David Anrews
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 0123977703
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Summary : The epidermal growth factor receptor (EGFR) tyrosine kinase is a target for cancer chemotherapy. This chapter describes the discovery of small-molecule inhibitors of the kinase, their characterization and the medicinal chemistry programme that resulted in the identification of gefitinib. The development and studies undertaken to progress the drug in the ...

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : Jennifer Ann Littlechild
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 0123977703
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Summary : This chapter covers the general features of protein structure and recent advances in structural bioinformatics. The importance of the three-dimensional structure of the protein target in order to understand its mechanism of action as an aid for drug design is illustrated by specific examples of enzyme inhibition, receptor interactions and ...

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : C. Robin Ganellin
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 0123977703
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Summary : A brief introduction to cholesterol and lipoproteins is followed by a short account of the types of drugs which reduce cholesterol levels (bile sequestrants, hypocholesterolaemics, fibrates as acyl-CoA:cholesterol acyltransferase (ACAT) inhibitors, statins as 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, and saponins). This chapter continues with a background to the extraordinary ...

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : Wolfgang Jelkmann
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 0123977703
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Summary : The renal hormone erythropoietin (Epo) is essential for the viability and proliferation of the erythrocytic progenitors generating reticulocytes in the bone marrow. Human Epo consists of a chain of 165 amino acid residues and four glycans. The synthesis of Epo is strongly stimulated by hypoxia. Epo deficiency is the primary cause ...

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : Charles W. Richard
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 0123977703
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Summary : Lysosomal storage disorders (LSDs) represent a group of about 50 genetic disorders caused by deficiencies of lysosomal proteins. The missing lysosomal protein causes a build-up of toxic metabolites in the cells of patients, leading to progressive multisystem disease and premature death. Although individually rare, the combined prevalence of all lysosomal disorders ...

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : Denis Mulleman,Marc Ohresser,Hervé Watier
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 0123977703
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Summary : Parallel studies in septic shock and cancer led to the discovery of the endogenous factors named cachectin and tumour necrosis factor (TNF), respectively, that were shown to be structurally and functionally similar. Further studies identified two forms of TNF, TNF-α and TNF-β. The anticipation that specific anti-TNF antibody might have ...

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : Arun K. Ghosh,Bruno D. Chapsal
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 0123977703
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Summary : The development of HIV protease inhibitors (PIs) and their inclusion in highly active antiretroviral therapies (HAARTs) marked the beginning of a treatment breakthrough in the management of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS). The HAART treatment regimen can cut HIV viral load to undetectable levels. Nonetheless, the rapid ...

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : null Hasmann
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 0123977703
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Summary : HER2 (ErbB-2) is a member of the human epidermal growth factor receptor tyrosine kinase family which is involved in the regulation of cell proliferation, survival and differentiation. Soon after its discovery, HER2 was shown frequently to be overexpressed in breast cancer and was associated with a worse prognosis. It was ...

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development
  • Author : Stanley M. Roberts
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-07
  • Total pages : 472
  • ISBN : 0123977703
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Summary : Menopause affects the quality of life for women, sometimes severely. The symptoms can be addressed by treatment with steroids, namely, an oestrogen alone or an oestrogen with a progestin. The treatment is called hormone replacement therapy (HRT). However, for years, HRT has been associated with side effects, for instance, an ...