Structure and Function of Intrinsically Disordered Proteins

Written By Peter Tompa
Structure and Function of Intrinsically Disordered Proteins
  • Publsiher : CRC Press
  • Release : 18 November 2009
  • ISBN : 9781420078930
  • Pages : 359 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Structure and Function of Intrinsically Disordered Proteins written by Peter Tompa which was release on 18 November 2009, this book published by CRC Press. Available in PDF, EPUB and Kindle Format. Book excerpt: The existence and functioning of intrinsically disordered proteins (IDPs) challenge the classical structure-function paradigm that equates function with a well-defined 3D structure. Uncovering the disordered complement of proteomes and understanding their functioning can extend the structure-function paradigm to herald new breakthroughs in drug development. Structure and Function of Intrinsically Disordered Proteins thoroughly covers the history up to the latest developments in this field. After examining the principles of protein structure, the classical paradigm, and the history of structural disorder, the book focuses on physical techniques for the identification and characterization of IDPs. It discusses proteomic and bioinformatic approaches and shows how IDPs behave under crowding conditions in living cells. The next several chapters describe the structure, correlating biological processes, and molecular mechanisms of IDPs. The author also explores the evolutionary advancement of structural disorder in proteomes and possible ways of extending the structure-function paradigm to encompass both ordered and disordered states of proteins. He concludes with discussions on the involvement of IDPs in various diseases and how to establish rational drug design through detailed characterization of IDPs. Although drug discovery rates have leveled off, new insight generated by the study of IDPs may offer fresh strategies for drug development. This work illustrates how these proteins defy the structure-function paradigm and play important regulatory and signaling roles.

Structure and Function of Intrinsically Disordered Proteins

Structure and Function of Intrinsically Disordered Proteins
  • Author : Peter Tompa,Alan Fersht
  • Publisher : CRC Press
  • Release Date : 2009-11-18
  • Total pages : 359
  • ISBN : 9781420078930
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Summary : The existence and functioning of intrinsically disordered proteins (IDPs) challenge the classical structure-function paradigm that equates function with a well-defined 3D structure. Uncovering the disordered complement of proteomes and understanding their functioning can extend the structure-function paradigm to herald new breakthroughs in drug development. Structure and Function of Intrinsically Disordered ...

Intrinsically Disordered Protein Analysis

Intrinsically Disordered Protein Analysis
  • Author : Vladimir N. Uversky,A. Keith Dunker
  • Publisher : Humana Press
  • Release Date : 2012-07-05
  • Total pages : 511
  • ISBN : 9781420078930
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Summary : Over the past decade, there has been an explosive development of research of intrinsically disordered proteins (IDPs), which are also known as unfolded proteins. Structural biologists now recognize that the functional diversity provided by disordered regions complements the functional repertoire of ordered protein regions. In Intrinsically Disordered Protein Analysis :Methods ...

Intrinsically Disordered Proteins

Intrinsically Disordered Proteins
  • Author : Vladimir N. Uversky
  • Publisher : Springer
  • Release Date : 2014-08-05
  • Total pages : 61
  • ISBN : 9781420078930
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Summary : In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their ...

Intrinsically Disordered Proteins

Intrinsically Disordered Proteins
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2018-11-21
  • Total pages : 754
  • ISBN : 9781420078930
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Summary : Intrinsically Disordered Proteins, Volume 611, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics of interest, including the Characterization of Structure-Function relationships in the intrinsically disordered protein complexin, Distances, distance distributions, and ensembles of IDPs from ...

Intrinsically Disordered Proteins

Intrinsically Disordered Proteins
  • Author : Nicola Salvi
  • Publisher : Academic Press
  • Release Date : 2019-06-14
  • Total pages : 355
  • ISBN : 9781420078930
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Summary : Intrinsically Disordered Proteins: Dynamics, Binding, and Function thoroughly examines and ties together the fundamental biochemical functions of intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs), including signaling, binding, and regulation, with the methodology for study and the associated pathways for drug design and therapeutic intervention. The role of new ...

Dancing Protein Clouds Intrinsically Disordered Proteins in the Norm and Pathology

Dancing Protein Clouds  Intrinsically Disordered Proteins in the Norm and Pathology
  • Author : Vladimir Uversky
  • Publisher : Academic Press
  • Release Date : 2019-09-15
  • Total pages : 424
  • ISBN : 9781420078930
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Summary : "Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their ...

Intrinsically Disordered Proteins Studied by NMR Spectroscopy

Intrinsically Disordered Proteins Studied by NMR Spectroscopy
  • Author : Isabella C. Felli,Roberta Pierattelli
  • Publisher : Springer
  • Release Date : 2015-09-19
  • Total pages : 421
  • ISBN : 9781420078930
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Summary : This book discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). The properties of IDPs and IDPRs are highly complementary to those deriving from the presence of a unique and well-defined three-dimensional fold. Ignored for a long time in ...

Intrinsically Disordered Proteins

Intrinsically Disordered Proteins
  • Author : Birthe B Kragelund,Karen Skriver
  • Publisher : Humana
  • Release Date : 2020-07-05
  • Total pages : 951
  • ISBN : 9781420078930
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Summary : The edition details methods to study intrinsically disordered proteins (IDPs) including recent topics such as extremely high-affinity disordered complexes, kinetics that evade established concepts, liquid-liquid phase separation, and novel disorder-driven allosteric mechanisms. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, ...

Intrinsically Disordered Proteins IDPs

Intrinsically Disordered Proteins  IDPs
  • Author : Violet Weber
  • Publisher : Unknown
  • Release Date : 2016
  • Total pages : 115
  • ISBN : 9781420078930
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Summary : Intrinsically disordered proteins (IDPs) are biomolecules that do not have a definite 3D structure; their role in the biochemical network of a cell relates to their ability to switch rapidly among different secondary and tertiary structures. The emergence of IDPs has challenged the classical protein structure-function paradigm. IDPs play an ...

Dancing Protein Clouds Intrinsically Disordered Proteins in Health and Disease Part B

Dancing Protein Clouds  Intrinsically Disordered Proteins in Health and Disease  Part B
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2020-09-01
  • Total pages : 402
  • ISBN : 9781420078930
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Summary : Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and ...

Instrumental Analysis of Intrinsically Disordered Proteins

Instrumental Analysis of Intrinsically Disordered Proteins
  • Author : Vladimir Uversky,Sonia Longhi
  • Publisher : John Wiley & Sons
  • Release Date : 2011-01-31
  • Total pages : 600
  • ISBN : 9781420078930
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Summary : Instrumental techniques for analyzing intrinsically disordered proteins The recently recognized phenomenon of protein intrinsic disorder is gaining significant interest among researchers, especially as the number of proteins and protein domains that have been shown to be intrinsically disordered rapidly grows. The first reference to tackle this little-documented area, Instrumental Analysis ...

Dancing Protein Clouds

Dancing Protein Clouds
  • Author : Vladimir N. Uversky
  • Publisher : Unknown
  • Release Date : 2019
  • Total pages : 413
  • ISBN : 9781420078930
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Summary : ""Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their ...

Dancing Protein Clouds Intrinsically Disordered Proteins in the Norm and Pathology Part C

Dancing Protein Clouds  Intrinsically Disordered Proteins in the Norm and Pathology  Part C
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2021-11-15
  • Total pages : 300
  • ISBN : 9781420078930
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Summary : Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology, Part C represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this volume include discussion of the evolution of disorder; consideration of the peculiarities of phase separation of the ...

Unfolded Proteins

Unfolded Proteins
  • Author : Trevor P. Creamer
  • Publisher : Nova Publishers
  • Release Date : 2008
  • Total pages : 309
  • ISBN : 9781420078930
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Summary : The word revolution has a number of definitions (The American Heritage Dictionary, 2006). The one most pertinent to this series and volume is 'a sudden or momentous change in a situation'. Recent years have seen an unprecedented explosion of interest in unfolded proteins in all of their various forms. Coupled with ...

Intrinsically Disordered Proteins Share a Common Molecular Mechanism in Membranes Damages Lipid chaperone Hypothesis

Intrinsically Disordered Proteins Share a Common Molecular Mechanism in Membranes Damages  Lipid chaperone Hypothesis
  • Author : Carmelo La Rosa
  • Publisher : Unknown
  • Release Date : 2017
  • Total pages : 212
  • ISBN : 9781420078930
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Summary : Researchers over the past thirty years have highlighted the role played by a class of small proteins that form pathogenic amyloid aggregates in vivo include the amyloid Au03b2 peptide (Alzheimeru2019s disease), u03b1-synuclein (Parkinsonu2019s disease), and IAPP, (type 2 diabetes). These proteins called also intrinsically disordered proteins (...