G Protein Coupled Receptors

Written By Sandra Siehler
G Protein Coupled Receptors
  • Publsiher : Cambridge University Press
  • Release : 30 September 2010
  • ISBN : 1139491741
  • Pages : 212 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled G Protein Coupled Receptors written by Sandra Siehler which was release on 30 September 2010, this book published by Cambridge University Press. Available in PDF, EPUB and Kindle Format. Book excerpt: Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology of GPCRs, in new assay technologies and drug targeting. The authors take time to detail the importance of the pathophysiological function and drug targeting of GPCRs, specifically β-adrenoceptors in cardiovascular and respiratory diseases, metabotropic glutamate receptors in CNS disorders, S1P receptors in the immune system, and Wnt/Frizzled receptors in osteoporosis. This book will be invaluable to researchers and graduate students in academia and industry who are interested in the GPCR field.

G Protein Coupled Receptors

G Protein Coupled Receptors
  • Author : Sandra Siehler,Graeme Milligan
  • Publisher : Cambridge University Press
  • Release Date : 2010-09-30
  • Total pages : 212
  • ISBN : 1139491741
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Summary : Provides a comprehensive overview of recent discoveries and current understandings of G protein-coupled receptors (GPCRs). Recent advances include the first mammalian non-rhodopsin GPCR structures and reconstitution of purified GPCRs into membrane discs for defined studies, novel signaling features including oligomerization, and advances in understanding the complex ligand pharmacology and physiology ...

Multivalent Ligands

Multivalent Ligands
  • Author : Anabel Molero Milan,Universitat de Barcelona. Departament de Química Orgànica
  • Publisher : Unknown
  • Release Date : 2011
  • Total pages : 284
  • ISBN : 1139491741
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Summary : Download or read online Multivalent Ligands written by Anabel Molero Milan,Universitat de Barcelona. Departament de Química Orgànica, published by which was released on 2011. Get Multivalent Ligands Books now! Available in PDF, ePub and Kindle....

Ligand Design for G Protein coupled Receptors Volume 30

Ligand Design for G Protein coupled Receptors  Volume 30
  • Author : Didier Rognan,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
  • Publisher : John Wiley & Sons
  • Release Date : 2006-03-10
  • Total pages : 264
  • ISBN : 1139491741
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Summary : 1. G protein-coupled receptors in the human genome -- 2. Why G protein-coupled receptors databases are needed -- 3. A novel drug screening assay for G protein-coupled receptors -- 4. Importance of GPCR dimerization for function : the case of the class C GPCRs -- 5. Molecular mechanisms of GPCR activation -- 6. Allosteric properties and regulation ...

G Protein Coupled Receptors Modeling and Simulation

G Protein Coupled Receptors   Modeling and Simulation
  • Author : Marta Filizola
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-10-25
  • Total pages : 228
  • ISBN : 1139491741
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Summary : G protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses. Since GPCRs are natural targets for approximately 40% of all modern medicines, it is not surprising that they have been the subject of intense research. Notwithstanding the amount of data generated ...

GPCRs

GPCRs
  • Author : Beata Jastrzebska,Paul S. H. Park
  • Publisher : Academic Press
  • Release Date : 2019-10
  • Total pages : 552
  • ISBN : 1139491741
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Summary : GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric ...

GPCRs From Deorphanization to Lead Structure Identification

GPCRs  From Deorphanization to Lead Structure Identification
  • Author : H. Bourne,Richard Horuk,J. Kuhnke,H. Michel
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-05-23
  • Total pages : 269
  • ISBN : 1139491741
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Summary : This book offers an insight into the approaches taken by industry and academia to address GPCRs and depict how mature this target class-oriented research has become in the last decade. Coverage also reflects the actual trends in the fast-emerging field of GPCR research in academia and industry. It is based ...

G Protein Coupled Receptors

G Protein Coupled Receptors
  • Author : David Poyner,Mark Wheatley
  • Publisher : John Wiley & Sons
  • Release Date : 2009-12-11
  • Total pages : 310
  • ISBN : 1139491741
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Summary : G-Protein Coupled Receptors (GPCRs) are not only the largest protein family in the human genome but are also the single biggest target for therapeutic agents. Research into GPCRs is therefore growing at a fast pace and the range of techniques that can be applied to GPCRs is vast and continues ...

Adhesion GPCRs

Adhesion   GPCRs
  • Author : Simon Yona,Martin Stacey
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-06-26
  • Total pages : 199
  • ISBN : 1139491741
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Summary : Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand–receptor complex into ...

Adhesion G Protein coupled Receptors

Adhesion G Protein coupled Receptors
  • Author : Tobias Langenhan,Torsten Schöneberg
  • Publisher : Springer
  • Release Date : 2016-11-09
  • Total pages : 403
  • ISBN : 1139491741
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Summary : Latest research on Adhesion GPCRs has unearthed surprising revelations about the events that govern the signal transduction of these receptor molecules and the cellular and organ requirements for these signals. Unexpected and unprecedented findings suggest that Adhesion GPCRs constitute a group of receptors that sense mechanical stimuli and transcode them ...

GPCRs

GPCRs
  • Author : Beata Jastrzebska,Paul S.-H. Park
  • Publisher : Academic Press
  • Release Date : 2019-09-11
  • Total pages : 500
  • ISBN : 1139491741
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Summary : GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric ...

G Protein coupled Receptors

G Protein coupled Receptors
  • Author : Georges Vauquelin,Bengt von Mentzer
  • Publisher : John Wiley & Sons
  • Release Date : 2008-03-11
  • Total pages : 264
  • ISBN : 1139491741
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Summary : G protein-coupled receptors (GPCRs) are membrane proteins that transduce a vast array of extracellular signals into intracellular reactions ranging from cell-cell communication processes to physiological responses. They play an important role in a variety of diseases from cancer and diabetes, to neurodegenerative, inflammatory and respiratory disorders. GPCRs are therefore of ...

G Protein Coupled Receptors

G Protein Coupled Receptors
  • Author : Jesus Giraldo,Jean-Philippe Pin
  • Publisher : Royal Society of Chemistry
  • Release Date : 2011
  • Total pages : 511
  • ISBN : 1139491741
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Summary : This book considers the relationship between structure and function in G protein-coupled receptors (GPCRs) and the implications for drug design....

G protein Coupled Receptor GPCR induced Epidermal Growth Factor Receptor EGFR Transactivation

G protein Coupled Receptor  GPCR  induced Epidermal Growth Factor Receptor  EGFR  Transactivation
  • Author : Chintda Santiskulvong
  • Publisher : Unknown
  • Release Date : 2006
  • Total pages : 278
  • ISBN : 1139491741
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Summary : Download or read online G protein Coupled Receptor GPCR induced Epidermal Growth Factor Receptor EGFR Transactivation written by Chintda Santiskulvong, published by which was released on 2006. Get G protein Coupled Receptor GPCR induced Epidermal Growth Factor Receptor EGFR Transactivation Books now! Available in PDF, ePub and Kindle....

Structure and Function of GPCRs

Structure and Function of GPCRs
  • Author : Guillaume Lebon
  • Publisher : Springer
  • Release Date : 2019-08-01
  • Total pages : 289
  • ISBN : 1139491741
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Summary : This book introduces readers to the latest advances in G protein-coupled receptor (GPCR) biology. It reviews our current understanding of the structural basis of ligand binding and allosteric mechanisms, following a decade of technological breakthroughs. Several examples of structure-based drug discovery are presented, together with the future challenges involved in ...

The G Protein Coupled Receptors Handbook

The G Protein Coupled Receptors Handbook
  • Author : Lakshmi A. Devi
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-03-01
  • Total pages : 412
  • ISBN : 1139491741
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Summary : A comprehensive survey of the many recent advances in the field of G protein-coupled receptors (GPCR). The authors describe the current knowledge of GPCR receptor structure and function, the different mechanisms involved in the regulation of GPCR function, and the role of pharmacological chaperones in GPCR folding and maturation. They ...