Structure and Function of GPCRs

Written By Guillaume Lebon
Structure and Function of GPCRs
  • Publsiher : Springer
  • Release : 01 August 2019
  • ISBN : 3030245918
  • Pages : 289 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Structure and Function of GPCRs written by Guillaume Lebon which was release on 01 August 2019, this book published by Springer. Available in PDF, EPUB and Kindle Format. Book excerpt: This book introduces readers to the latest advances in G protein-coupled receptor (GPCR) biology. It reviews our current understanding of the structural basis of ligand binding and allosteric mechanisms, following a decade of technological breakthroughs. Several examples of structure-based drug discovery are presented, together with the future challenges involved in designing better drugs that target GPCRs. In turn, the book illustrates the important concept of GPCR biased signaling in physiological contexts, and presents fluorescent- and light-based methodologies frequently used to measure GPCR signaling or to trace their dynamics in cells upon ligand activation. Taken together, the chapters provide an essential overview and toolkit for new scientific investigators who plan to develop GPCR projects. All chapters were written by experts in their respective fields, and share valuable insights and powerful methodologies for the GPCR field.

Structure and Function of GPCRs

Structure and Function of GPCRs
  • Author : Guillaume Lebon
  • Publisher : Springer
  • Release Date : 2019-08-01
  • Total pages : 289
  • ISBN : 3030245918
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Summary : This book introduces readers to the latest advances in G protein-coupled receptor (GPCR) biology. It reviews our current understanding of the structural basis of ligand binding and allosteric mechanisms, following a decade of technological breakthroughs. Several examples of structure-based drug discovery are presented, together with the future challenges involved in ...

Metabotropic GPCRs TGR5 and P2Y Receptors in Health and Diseases

Metabotropic GPCRs  TGR5 and P2Y Receptors in Health and Diseases
  • Author : Senthilkumar Rajagopal,Murugavel Ponnusamy
  • Publisher : Springer
  • Release Date : 2018-11-19
  • Total pages : 76
  • ISBN : 3030245918
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Summary : This book will provide current understandings about two ubiquitously expressed metabotropic GPCRs, G-coupled purinoreceptor type 2 (P2Y) and Takeda G-protein-coupled bile acid receptor 5 (TGR5). G protein coupled receptors (GPCRs) are the largest family of proteins implicated in majority of cellular responses. The two receptor sub-families play a central role in ...

Adhesion GPCRs

Adhesion   GPCRs
  • Author : Simon Yona,Martin Stacey
  • Publisher : Springer
  • Release Date : 2011-01-11
  • Total pages : 199
  • ISBN : 3030245918
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Summary : Upon completion of the human genome project over 800 G protein-coupled receptor 1 (GPCR) genes, subdivided into five categories, were identified. These receptors sense a diverse array of stimuli, including peptides, ions, lipid analogues, light and odour, in a discriminating fashion. Subsequently, they transduce a signal from the ligand–receptor complex into ...

G Protein Coupled Receptors in Drug Discovery

G Protein Coupled Receptors in Drug Discovery
  • Author : Wayne R. Leifert
  • Publisher : Humana Press
  • Release Date : 2016-08-23
  • Total pages : 376
  • ISBN : 3030245918
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Summary : The G protein-coupled receptors (GPCRs) and associated peripheral G proteins underpin a multitude of physiological processes. The GPCRs represent one of the largest superfamilies in the human genome and are a significant target for bioactive and drug discovery programs. It is estimated that greater than 50% of all drugs, including those ...

Modelling of GPCRs

Modelling of GPCRs
  • Author : Andrea Strasser,Hans-Joachim Wittmann
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-08-13
  • Total pages : 218
  • ISBN : 3030245918
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Summary : G protein coupled receptors (GPCRs) comprise an important protein family, which is involved in signal transduction in the cell. Besides that a large number of drugs, available on market, address GPCRs. For an efficient and improved development of appropriate drugs, molecular modelling of GPCRs is – in order to understand the ...

G Protein Coupled Receptors in Health and Disease

G Protein Coupled Receptors in Health and Disease
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2009-08-05
  • Total pages : 224
  • ISBN : 3030245918
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Summary : G protein-coupled receptors (GPCRs) transduce signals from a diverse array of endogenous ligands, including ions, amino acids, nucleotides, lipids, peptides, and large glycoprotein hormones. They are also responsible for our sensing of exogenous stimuli, including photons and odorants. GPCRs regulate almost every aspect of our physiological functions. It is estimated ...

The G Protein Coupled Receptors Handbook

The G Protein Coupled Receptors Handbook
  • Author : Lakshmi A. Devi
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-03-01
  • Total pages : 412
  • ISBN : 3030245918
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Summary : A comprehensive survey of the many recent advances in the field of G protein-coupled receptors (GPCR). The authors describe the current knowledge of GPCR receptor structure and function, the different mechanisms involved in the regulation of GPCR function, and the role of pharmacological chaperones in GPCR folding and maturation. They ...

G Protein Coupled Receptors

G Protein Coupled Receptors
  • Author : Arun K. Shukla
  • Publisher : Academic Press
  • Release Date : 2017
  • Total pages : 260
  • ISBN : 3030245918
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Summary : G Protein Coupled Receptors, Second Edition, Volume 143, a new volume in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. It contains a wide array of topics about the G protein coupled receptors, as well as updates ...

GPCR Molecular Pharmacology and Drug Targeting

GPCR Molecular Pharmacology and Drug Targeting
  • Author : Annette Gilchrist
  • Publisher : John Wiley & Sons
  • Release Date : 2010-12-10
  • Total pages : 544
  • ISBN : 3030245918
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Summary : G protein-coupled receptors (GPCRs) are a large protein family of transmembrane receptors vital in dictating cellular responses. GPCRs are involved in many diseases, but are also the target of around half of all modern medicinal drugs. Shifting Paradigms in G Protein Coupled Receptors takes a look at the way GPCRs ...

G Protein Coupled Receptors Modeling and Simulation

G Protein Coupled Receptors   Modeling and Simulation
  • Author : Marta Filizola
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-10-25
  • Total pages : 228
  • ISBN : 3030245918
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Summary : G protein-coupled receptors (GPCRs) are heptahelical transmembrane receptors that convert extra-cellular stimuli into intra-cellular signaling, and ultimately into biological responses. Since GPCRs are natural targets for approximately 40% of all modern medicines, it is not surprising that they have been the subject of intense research. Notwithstanding the amount of data generated ...

G Protein Coupled Receptors as Drug Targets

G Protein Coupled Receptors as Drug Targets
  • Author : Roland Seifert,Thomas Wieland
  • Publisher : John Wiley & Sons
  • Release Date : 2006-05-12
  • Total pages : 304
  • ISBN : 3030245918
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Summary : With its particular emphasis on the constitutive activity of G-protein-coupled receptors (GPCRs)s, this book comprehensively discusses an important biological process that has not yet been covered in such depth in any other existing books on GPCRs. The international team of highly distinguished authors addresses in detail current models and ...

Ligand Design for G Protein coupled Receptors Volume 30

Ligand Design for G Protein coupled Receptors  Volume 30
  • Author : Didier Rognan,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
  • Publisher : John Wiley & Sons
  • Release Date : 2006-03-10
  • Total pages : 264
  • ISBN : 3030245918
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Summary : 1. G protein-coupled receptors in the human genome -- 2. Why G protein-coupled receptors databases are needed -- 3. A novel drug screening assay for G protein-coupled receptors -- 4. Importance of GPCR dimerization for function : the case of the class C GPCRs -- 5. Molecular mechanisms of GPCR activation -- 6. Allosteric properties and regulation ...

Monitoring endogenous GPCRs lessons for drug design

Monitoring endogenous GPCRs  lessons for drug design
  • Author : Dominique Massotte
  • Publisher : Unknown
  • Release Date : 2015-10-07
  • Total pages : 212
  • ISBN : 3030245918
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Summary : G protein-coupled receptors (GPCRs) are integral membrane proteins forming the fourth largest superfamily in the human genome. Many of these receptors play key physiological roles and several pathologies have been associated with receptor functional abnormalities. GPCRs therefore represent important goals for drug design in pharmaceutical companies since they constitute the ...

GPCRs From Deorphanization to Lead Structure Identification

GPCRs  From Deorphanization to Lead Structure Identification
  • Author : H. Bourne,Richard Horuk,J. Kuhnke,H. Michel
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-07-03
  • Total pages : 269
  • ISBN : 3030245918
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Summary : This book offers an insight into the approaches taken by industry and academia to address GPCRs and depict how mature this target class-oriented research has become in the last decade. Coverage also reflects the actual trends in the fast-emerging field of GPCR research in academia and industry. It is based ...

G Protein Coupled Receptors in Immune Response and Regulation

G Protein Coupled Receptors in Immune Response and Regulation
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2017-09-23
  • Total pages : 398
  • ISBN : 3030245918
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Summary : G Protein-Coupled Receptors in Immune Response and Regulation, Volume 136 presents emerging concepts related to the role of GPCRs in immune response and regulation. Users will find updated chapters on a variety of topics, including Beta-adrenergic signaling in the onset and progression of asthma, the Emerging roles of Regulators of G ...