Genome Chaos

Written By Henry H. Heng
Genome Chaos
  • Publsiher : Academic Press
  • Release : 25 May 2019
  • ISBN : 0128136367
  • Pages : 556 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Genome Chaos written by Henry H. Heng which was release on 25 May 2019, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macro-evolution. In authoring this thought-provoking text, Dr. Heng invigorates fresh discussions in genome theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine. Bridges basic research and clinical application and provides a foundation for re-examining the results of large-scale omics studies and advancing molecular medicine Gathers the most pressing questions in genomic and cytogenomic research Offers alternative explanations to timely puzzles in the field Contains eight evidence-based chapters that discuss 4d-genomics, genes and genomes as distinct biological entities, genome chaos and macro-cellular evolution, evolutionary cytogenetics and cancer, chromosomal coding and fuzzy inheritance, and more

Genome Chaos

Genome Chaos
  • Author : Henry H. Heng
  • Publisher : Academic Press
  • Release Date : 2019-05-25
  • Total pages : 556
  • ISBN : 0128136367
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Summary : Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macro-evolution. In authoring this ...

Chromosome Biology as a Key to Understand Disease Mechanisms Genome Architecture and Evolution

Chromosome Biology as a Key to Understand Disease Mechanisms  Genome Architecture and Evolution
  • Author : Anja Weise,Philipp G. Maass,Ron Hochstenbach
  • Publisher : Frontiers Media SA
  • Release Date : 2021-04-16
  • Total pages : 212
  • ISBN : 0128136367
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Summary : This topic has been realized, and is in collaboration with Dr. Constanze Pentzold, Post Doctoral Researcher at the Institute of Human Genetics, University Hospital Jena....

Intratumor Diversity and Clonal Evolution in Cancer

Intratumor Diversity and Clonal Evolution in Cancer
  • Author : David Gisselsson
  • Publisher : Academic Press
  • Release Date : 2011-09-29
  • Total pages : 368
  • ISBN : 0128136367
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Summary : This specialized volume of Advances in Cancer Research is dedicated to the complex and largely unexplored field of intratumor diversity, with respect to differences in both genotype and phenotype among cell populations within tumors. Unique subject matter: there are relatively few previous publications covering this complex topic, even though it ...

Debating Cancer

Debating Cancer
  • Author : Henry H Heng
  • Publisher : World Scientific
  • Release Date : 2015-10-08
  • Total pages : 464
  • ISBN : 0128136367
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Summary : Cancer research is at a crossroads. Traditionally, cancer has been thought of as a disease of gene mutation, where the stepwise accumulation of cancer gene mutations is the key, and the identification of common gene mutations has been considered to be essential for diagnosis and treatment. Despite extensive research efforts ...

Ecology and Evolution of Cancer

Ecology and Evolution of Cancer
  • Author : Beata Ujvari,Benjamin Roche,Frederic Thomas
  • Publisher : Academic Press
  • Release Date : 2017-02-08
  • Total pages : 290
  • ISBN : 0128136367
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Summary : Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology, and cancer, but also goes beyond by connecting the interfaces of these disciplines. This work engages the expertise of a multidisciplinary research team to ...

Embracing Complexity in Health

Embracing Complexity in Health
  • Author : Joachim P. Sturmberg
  • Publisher : Springer
  • Release Date : 2019-05-16
  • Total pages : 335
  • ISBN : 0128136367
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Summary : This detailed volume illustrates the transformative nature of systems and complexity sciences for practice, research, education, and health system organization. Researchers highlight the fresh perspectives and novel approaches offered by these interdisciplinary fields in addressing the complexities of global, national, and community health challenges in the 21st century. With the ...

Human Interphase Chromosomes

Human Interphase Chromosomes
  • Author : Yuri B. Yurov,Svetlana G. Vorsanova,Ivan Y. Iourov
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-04-03
  • Total pages : 216
  • ISBN : 0128136367
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Summary : This title will focus on the study of human interphase chromosomes and its relation to health and disease. Orchestrated organization and human genome function in interphase nuclei at the chromosomal level have been repeatedly shown to play a significant role in a variety of basic biological processes involved in realization ...

Atlas of Hematopathology

Atlas of Hematopathology
  • Author : Faramarz Naeim,P. Nagesh Rao,Sophie X. Song,Ryan T. Phan
  • Publisher : Academic Press
  • Release Date : 2018-06-22
  • Total pages : 984
  • ISBN : 0128136367
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Summary : Atlas of Hematopathology: Morphology, Immunophenotype, Cytogenetics, and Molecular Approaches, Second Edition, will appeal to both a wide range of people undergoing training in a variety of medical fields and practicing non-hematopathologists. For clinicians, fellows and residents, correct diagnosis (and therefore correct treatment) of diseases depends on a strong understanding of ...

Epigenetics in Cancer

Epigenetics in Cancer
  • Author : Wiley
  • Publisher : John Wiley & Sons
  • Release Date : 2013-07-12
  • Total pages : 174
  • ISBN : 0128136367
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Summary : Epigenetics is the study of heritable changes in gene expression or cellular phenotype, caused by mechanisms other than changes in the DNA sequence. Examples include DNA methylation and histone modification. These changes may remain through cell divisions and multiple generations. Epigenetic differences among individuals may account for some of the ...

Human Interphase Chromosomes

Human Interphase Chromosomes
  • Author : Ivan Iourov,Svetlana Vorsanova,I︠u︡riĭ Borisovich I︠u︡rov,Yuri Yurov
  • Publisher : Springer Nature
  • Release Date : 2020
  • Total pages : 178
  • ISBN : 0128136367
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Summary : This second edition focuses on the study of human interphase chromosomes and its relation to health and disease. Orchestrated organization and behavior of the human genome in interphase nuclei at chromosomal level has been repeatedly shown to play a significant role in almost all basic biological processes involved in the ...

Effective Drug Treatment Induces Drug Resistance Through Rapid Genome Alteration mediated Cancer Evolution

Effective Drug Treatment Induces Drug Resistance Through Rapid Genome Alteration mediated Cancer Evolution
  • Author : Steven Horne
  • Publisher : Unknown
  • Release Date : 2016
  • Total pages : 140
  • ISBN : 0128136367
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Summary : The central paradox associated with current cancer therapeutic strategies is initially effective treatment, which eliminates a high tumor cell count, consistently results in successful drug resistance. Mathematical and evolutionary modeling have previously suggested that therapeutic intervention could provide selective pressure for the expansion of resistant variants. Drug-related stress has been ...

Handbook of Systems and Complexity in Health

Handbook of Systems and Complexity in Health
  • Author : Joachim P Sturmberg,Carmel Martin
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-01-09
  • Total pages : 954
  • ISBN : 0128136367
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Summary : This book is an introduction to health care as a complex adaptive system, a system that feeds back on itself. The first section introduces systems and complexity theory from a science, historical, epistemological, and technical perspective, describing the principles and mathematics. Subsequent sections build on the health applications of systems ...

Evolutionary Computation in Bioinformatics

Evolutionary Computation in Bioinformatics
  • Author : Gary B. Fogel,David W. Corne
  • Publisher : Morgan Kaufmann
  • Release Date : 2003
  • Total pages : 393
  • ISBN : 0128136367
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Summary : This book offers a definitive resource that bridges biology and evolutionary computation. The authors have written an introduction to biology and bioinformatics for computer scientists, plus an introduction to evolutionary computation for biologists and for computer scientists unfamiliar with these techniques....

Chaos Information Processing and Paradoxical Games

Chaos  Information Processing and Paradoxical Games
  • Author : Gregoire Nicolis,Vasileios Basios
  • Publisher : World Scientific
  • Release Date : 2014-12-30
  • Total pages : 476
  • ISBN : 0128136367
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Summary : This volume provides a self-contained survey of the mechanisms presiding information processing and communication. The main thesis is that chaos and complexity are the basic ingredients allowing systems composed of interesting subunits to generate and process information and communicate in a meaningful way. Emphasis is placed on communication in the ...

The Value of Systems and Complexity Sciences for Healthcare

The Value of Systems and Complexity Sciences for Healthcare
  • Author : Joachim P Sturmberg
  • Publisher : Springer
  • Release Date : 2016-03-01
  • Total pages : 285
  • ISBN : 0128136367
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Summary : This visionary reframing of health and healthcare uses a complexity science approach to building healthcare systems that are accessible, effective, and prepared for change and challenges. Its holistic map for understanding the human organism emphasizes the interconnectedness of the individual’s physical, psychological, cognitive, and sociocultural functioning. Applications of this ...