Drug Efflux Pumps in Cancer Resistance Pathways From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy

Written By Anonim
Drug Efflux Pumps in Cancer Resistance Pathways  From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy
  • Publsiher : Academic Press
  • Release : 07 November 2019
  • ISBN : 0128141417
  • Pages : 394 pages
  • Rating : 4/5 from 21 reviews
GET THIS BOOKDrug Efflux Pumps in Cancer Resistance Pathways From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy


Read or download book entitled Drug Efflux Pumps in Cancer Resistance Pathways From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy written by Anonim which was release on 07 November 2019, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy, Volume Seven, describes the fundamental aspects of efflux pumps of the ATP-binding cassette superfamily in cancer resistance pathways, along with strategies to target and improve chemotherapy efficacy. Pumps of the ATP-binding cassette superfamily (ABCs) regulate the access of drugs to the intracellular space. In this context, the overexpression of ABCs is a well-known mechanism of multidrug resistance in cancer and is associated with therapeutic failure. Cancer types discussed include breast, endocrine, hematologic, gastrointestinal, musculoskeletal, lung, skin and central nervous system cancers. The book is a valuable source for researchers and advanced students in cancer, biology, pharmacology, pharmaceutical sciences, biomaterials and medical/clinical sciences that are interested in accessing a comprehensive compendium on efflux pumps in mechanisms of cancer resistance. Offers comprehensive and detailed descriptions of the basic aspects of efflux pumps in a very schematic and didactic manner Describes the involvement of efflux pumps in cancer resistance in different cancer types Encompasses an updated overview on state-of-the-art approaches that capitalize on their inhibition to improve chemotherapy and overcome resistance

Drug Efflux Pumps in Cancer Resistance Pathways From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy

Drug Efflux Pumps in Cancer Resistance Pathways  From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-11-07
  • Total pages : 394
  • ISBN : 0128141417
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Summary : Drug Efflux Pumps in Cancer Resistance Pathways: From Molecular Recognition and Characterization to Possible Inhibition Strategies in Chemotherapy, Volume Seven, describes the fundamental aspects of efflux pumps of the ATP-binding cassette superfamily in cancer resistance pathways, along with strategies to target and improve chemotherapy efficacy. Pumps of the ATP-binding cassette ...

Drug Resistance in Bacteria Fungi Malaria and Cancer

Drug Resistance in Bacteria  Fungi  Malaria  and Cancer
  • Author : Gunjan Arora,Andaleeb Sajid,Vipin Chandra Kalia
  • Publisher : Springer
  • Release Date : 2017-03-21
  • Total pages : 630
  • ISBN : 0128141417
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Summary : This book is a compilation of past and recent knowledge in the field of emerging drug resistance. The book covers major aspects of drug resistance in bacteria, fungi, malaria, and cancer.Human survival on earth is constantly threatened by disease and syndrome. From the early days, the aim of research ...

The PI3kinase Pathway and the Susceptibility of Its Inhibitors to ABC Transporters

The PI3kinase Pathway and the Susceptibility of Its Inhibitors to ABC Transporters
  • Author : Ripudaman Singh
  • Publisher : Unknown
  • Release Date : 2012
  • Total pages : 220
  • ISBN : 0128141417
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Summary : The PI3kinase pathway and ABC transporters play a crucial role in normal growth, survival and death of a cell. However in cancer cells, disturbances in these pathways lead to uncontrolled growth even under treatment of various anticancer drugs. Two major efflux pumps i.e. p-glycoprotein (Pgp) and multidrug resistance ...

Using Natural Products to Elucidate a Multidrug Resistance Pathway

Using Natural Products to Elucidate a Multidrug Resistance Pathway
  • Author : Kara Michelle Pearson
  • Publisher : Unknown
  • Release Date : 2000
  • Total pages : 132
  • ISBN : 0128141417
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Summary : Download or read online Using Natural Products to Elucidate a Multidrug Resistance Pathway written by Kara Michelle Pearson, published by which was released on 2000. Get Using Natural Products to Elucidate a Multidrug Resistance Pathway Books now! Available in PDF, ePub and Kindle....

Overcoming Drug Resistance in Gynecologic Cancers

Overcoming Drug Resistance in Gynecologic Cancers
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2021-08-11
  • Total pages : 388
  • ISBN : 0128141417
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Summary : Overcoming Drug Resistance in Gynecologic Cancers provides up-to-date information related to important gynecologic cancers and focuses on mechanisms of drug resistance, genetics, signaling, immunology, health disparities, nanotechnology, economic considerations and financial impacts. The book covers not only drug resistance but also important means to reverse resistance both in the laboratory ...

Drug Resistance in Colorectal Cancer Molecular Mechanisms and Therapeutic Strategies

Drug Resistance in Colorectal Cancer  Molecular Mechanisms and Therapeutic Strategies
  • Author : Chi Hin Cho,Tao Hu
  • Publisher : Academic Press
  • Release Date : 2020-05-24
  • Total pages : 240
  • ISBN : 0128141417
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Summary : Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies, Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal cancer, along with the most up-to-date therapeutic strategies available. The book discusses reasons why colorectal tumors become refractory during the progression of the disease, but also explains how drug ...

Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance

Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance
  • Author : Andrew Freywald,Franco Vizeacoumar
  • Publisher : Academic Press
  • Release Date : 2020-12-04
  • Total pages : 308
  • ISBN : 0128141417
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Summary : Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance, Volume 12, discusses new approaches that are being undertaken to counteract tumor plasticity, understand and tackle the interactions with the microenvironment, and disrupt the rewiring of malignant cells or bypass biological mechanism of resistance by using targeted radionuclide therapies. This ...

Multiple Drug Resistance in Cancer 2

Multiple Drug Resistance in Cancer 2
  • Author : Martin Clynes
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-04-17
  • Total pages : 344
  • ISBN : 0128141417
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Summary : Resistance to chemotherapy, and especially multi-drug resistance, represents a significant barrier to the successful treatment of cancer. This multi-author volume brings together a wide range of up-to-date reviews on different aspects of our knowledge of drug-resistance mechanisms, written by experts in the different areas. Particular attention is paid to recently ...

Therapeutic Strategies to Overcome ALK Resistance in Cancer

Therapeutic Strategies to Overcome ALK Resistance in Cancer
  • Author : Luc Friboulet
  • Publisher : Academic Press
  • Release Date : 2021-01-18
  • Total pages : 216
  • ISBN : 0128141417
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Summary : Therapeutic Strategies to Overcome ALK Resistance in Cancer, Volume 13, presents current strategies to improve and prolong clinical benefit in ALK driven cancers. Most patients with ALK-driven cancer are sensitive to tyrosine kinase inhibitor (TKI) therapy, but resistance invariably develops. This book discusses topics such as structure and function of ALK, ...

Overcoming Ovarian Cancer Chemoresistance

Overcoming Ovarian Cancer Chemoresistance
  • Author : Goli Samimi,Christina Annunziata
  • Publisher : Academic Press
  • Release Date : 2020-11-06
  • Total pages : 188
  • ISBN : 0128141417
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Summary : Overcoming Ovarian Cancer Chemoresistance presents non-overlapping review chapters that discuss the state of the field in overcoming chemoresistance of ovarian cancer and treatment options before and following recurrence, considering the genetic makeup of the ovarian cancer patient and her tumor. With the uptake of both germline and somatic gene testing, ...

Signal and Response Signal Transduction

Signal and Response   Signal Transduction
  • Author : Amrit Rattan K. Baidwan-macfarland
  • Publisher : Authorhouse UK
  • Release Date : 2019-03-30
  • Total pages : 302
  • ISBN : 0128141417
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Summary : The ground-breaking scientific study of Amrit Rattan K Baidwan Macfarland (Amrit K Macfarland) asks why and how malignant cancers can be cured. This scientific status is visualised through novel ALL cells lines in vitro, in vivo, and in developing natural human foetal tissues. The resistance status of malignancy to treatment ...

Glioblastoma Resistance to Chemotherapy Molecular Mechanisms and Innovative Reversal Strategies

Glioblastoma Resistance to Chemotherapy  Molecular Mechanisms and Innovative Reversal Strategies
  • Author : Ramasamy Paulmurugan,Tarik F. Massoud
  • Publisher : Academic Press
  • Release Date : 2021-06-25
  • Total pages : 828
  • ISBN : 0128141417
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Summary : Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies brings current knowledge from an international team of experts on the science and clinical management of glioblastoma chemoresistance. The book discusses topics such as molecular mechanisms of chemoresistance, experimental models to study chemoresistance, chemoresistance to drugs other than Temozolomide, and ...

New Targeting in The Reversal of Resistant Glioblastomas

New Targeting in The Reversal of Resistant Glioblastomas
  • Author : Ali Syed Arbab
  • Publisher : Academic Press
  • Release Date : 2021-03-05
  • Total pages : 202
  • ISBN : 0128141417
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Summary : New Targeting in The Reversal of Resistant Glioblastomas discusses alternative treatment strategies that not only target tumor cells but also target the tumor microenvironment, metabolic pathways and interaction of cytokines in tumor cells. The current treatment for primary and recurrent glioblastomas is failing because clinicians are not considering the effect ...

Epigenetic Regulation in Overcoming Chemoresistance

Epigenetic Regulation in Overcoming Chemoresistance
  • Author : Chunfu Wu,Lihui Wang
  • Publisher : Academic Press
  • Release Date : 2021-06-26
  • Total pages : 144
  • ISBN : 0128141417
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Summary : Epigenetic Regulation in Overcoming Chemoresistance, Volume 19, explains how epigenetic agents can enhance the chemotherapy sensitivity of diverse types of cancers. The book provides a comprehensive delineation and the recent development of the scientific studies on the epigenetic regulation in enhancing chemo-sensitivity. In addition, it discusses several topics such as DNA ...

pH Interfering Agents as Chemosensitizers in Cancer Therapy

pH Interfering Agents as Chemosensitizers in Cancer Therapy
  • Author : Claudiu Supuran,Simone Carradori
  • Publisher : Academic Press
  • Release Date : 2020-09-15
  • Total pages : 228
  • ISBN : 0128141417
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Summary : pH Interfering Agents as Chemosensitizers In Cancer Therapy, Volume Thirteen, provides a detailed overview of the chemosensitizers for the treatment of cancer spanning from biochemical and structural features to pharmacology and drug-design, including technological applications. The book is structured with innovative outlines and a distinction between experimental and clinical results. ...