Domino Reactions in Drug Discovery

Written By Shanta Bhar
Domino Reactions in Drug Discovery
  • Publsiher : Elsevier
  • Release : 01 October 2020
  • ISBN : 9780128193747
  • Pages : 315 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Domino Reactions in Drug Discovery written by Shanta Bhar which was release on 01 October 2020, this book published by Elsevier. Available in PDF, EPUB and Kindle Format. Book excerpt: Domino Reactions in Drug Discovery presents a concise selection of domino reactions employed in routes for the synthesis of pharmaceuticals, agrochemicals and the design of new drug candidates. These versatile reactions play an important and integral part in both the aesthetic appeal and functional aspects of strategic drug discovery, lending enhanced efficiency and synthetic versatility to pharmaceutical drug design. Due to their atom economy, these reactions are increasingly popular in the development of complex scaffolds and multifunctional derivatives aimed at the synthesis of new chemical entities and approved APIs across diverse therapeutic classes, including antidiabetics [DPP4 inhibitors], anticancer therapies and HIV integrase inhibitors. Features illustrated schemes with mechanisms, procedures and results Includes a compendium of Domino Name Reactions for drugs Provides a concise, comprehensive coverage of domino reactions in drug discovery, with a focus on sustainable practices

Domino Reactions in Drug Discovery

Domino Reactions in Drug Discovery
  • Author : Shanta Bhar
  • Publisher : Elsevier
  • Release Date : 2020-10
  • Total pages : 315
  • ISBN : 9780128193747
GET BOOK

Summary : Domino Reactions in Drug Discovery presents a concise selection of domino reactions employed in routes for the synthesis of pharmaceuticals, agrochemicals and the design of new drug candidates. These versatile reactions play an important and integral part in both the aesthetic appeal and functional aspects of strategic drug discovery, lending ...

Synthesis of Aromatic Heterocycles by Palladium 0 catalyzed Domino Reactions and Cyclization of Hydrazone Dianions

Synthesis of Aromatic Heterocycles by Palladium 0  catalyzed Domino Reactions and Cyclization of Hydrazone Dianions
  • Author : Thang Ngoc Ngo
  • Publisher : Unknown
  • Release Date : 2016
  • Total pages : 212
  • ISBN : 9780128193747
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Summary : Download or read online Synthesis of Aromatic Heterocycles by Palladium 0 catalyzed Domino Reactions and Cyclization of Hydrazone Dianions written by Thang Ngoc Ngo, published by which was released on 2016. Get Synthesis of Aromatic Heterocycles by Palladium 0 catalyzed Domino Reactions and Cyclization of Hydrazone Dianions Books now! Available in PDF, ePub ...

Multicomponent Reactions

Multicomponent Reactions
  • Author : Jieping Zhu,Hugues Bienaymé
  • Publisher : John Wiley & Sons
  • Release Date : 2006-03-06
  • Total pages : 484
  • ISBN : 9780128193747
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Summary : In the very first book on this hot topic, the expert editors andauthors present a comprehensive overview of these elegantreactions. From the contents: Organoboron compounds Free-radical mediated multicomponent coupling reactions Applications in drug discovery Metal catalyzed reactions Total synthesis of natural products Asymmetric isocyanide-based reactions The Biginelli reaction Asymmetric isocyanide-based ...

Domino Reactions

Domino Reactions
  • Author : Lutz F. Tietze
  • Publisher : John Wiley & Sons
  • Release Date : 2013-12-23
  • Total pages : 648
  • ISBN : 9780128193747
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Summary : The follow-up to the successful "Domino Reaction in Organic Synthesis", this ready reference brings up to date on the original concept. The chapters have been arranged according to the name of well-known transformations of the first step and in combination with the formed products. Each chapter is written by an ...

Domino Reactions in Organic Synthesis

Domino Reactions in Organic Synthesis
  • Author : Lutz F. Tietze,Gordon Brasche,Kersten Gericke
  • Publisher : John Wiley & Sons
  • Release Date : 2006-12-13
  • Total pages : 631
  • ISBN : 9780128193747
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Summary : Domino reactions enable you to build complex structures in one-pot reactions without the need to isolate intermediates- a dream comes true. In this book, the well-respected expert, Professor Lutz Tietze, summarizes the possibilities of this reaction type - an approach for an efficiant, economically benificial and ecological benign synthesis. A ...

Asymmetric Domino Reactions

Asymmetric Domino Reactions
  • Author : Helene Pellissier
  • Publisher : Royal Society of Chemistry
  • Release Date : 2013-03-13
  • Total pages : 500
  • ISBN : 9780128193747
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Summary : This book covers the latest developments in asymmetric domino reactions, focussing on those published in the last 6 years. These fascinating reactions have rapidly become one of the most current fields in organic chemistry, since they allow reaching easily high molecular complexity in an economically favourable way with advantages of savings ...

Privileged Structures in Drug Discovery

Privileged Structures in Drug Discovery
  • Author : Larry Yet
  • Publisher : John Wiley & Sons
  • Release Date : 2018-03-07
  • Total pages : 560
  • ISBN : 9780128193747
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Summary : A comprehensive guide to privileged structures and their application in the discovery of new drugs The use of privileged structures is a viable strategy in the discovery of new medicines at the lead optimization stages of the drug discovery process. Privileged Structures in Drug Discovery offers a comprehensive text that ...

Diversity Oriented Synthesis

Diversity Oriented Synthesis
  • Author : Andrea Trabocchi
  • Publisher : John Wiley & Sons
  • Release Date : 2013-06-17
  • Total pages : 664
  • ISBN : 9780128193747
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Summary : Discover an enhanced synthetic approach to developing andscreening chemical compound libraries Diversity-oriented synthesis is a new paradigm for developinglarge collections of structurally diverse small molecules as probesto investigate biological pathways. This book presents the mosteffective methods in diversity-oriented synthesis for creatingsmall molecule collections. It offers tested and proven strategiesfor developing ...

Small Molecule Drug Discovery

Small Molecule Drug Discovery
  • Author : Andrea Trabocchi,Elena Lenci
  • Publisher : Elsevier
  • Release Date : 2019-11-23
  • Total pages : 356
  • ISBN : 9780128193747
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Summary : Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second ...

Medicinal Chemistry of Anticancer Drugs

Medicinal Chemistry of Anticancer Drugs
  • Author : Carmen Avendano,J. Carlos Menendez
  • Publisher : Elsevier
  • Release Date : 2015-06-11
  • Total pages : 768
  • ISBN : 9780128193747
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Summary : Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. ...

Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience

Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience
  • Author : Zbigniew J. Witczak,Roman Bielski
  • Publisher : John Wiley & Sons
  • Release Date : 2016-01-14
  • Total pages : 368
  • ISBN : 9780128193747
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Summary : The book consists of a brief introduction, a foreward provided byprofessor Danishefsky of Columbia University, and about 14 –16 chapters, each written by one or two eminent scholars/authorsdescribing their recent research in the area of either dominoreactions or intramolecular rearrangements in carbohydratechemistry. Three or four chapters will be reviews. The domino (...

Drug Discovery and Development

Drug Discovery and Development
  • Author : Ramarao Poduri
  • Publisher : Springer Nature
  • Release Date : 2021-07-27
  • Total pages : 212
  • ISBN : 9780128193747
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Summary : Download or read online Drug Discovery and Development written by Ramarao Poduri, published by Springer Nature which was released on . Get Drug Discovery and Development Books now! Available in PDF, ePub and Kindle....

Innovations in Green Chemistry and Green Engineering

Innovations in Green Chemistry and Green Engineering
  • Author : Paul T. Anastas,Julie B. Zimmerman
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-13
  • Total pages : 334
  • ISBN : 9780128193747
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Summary : Processes that meet the objectives of green chemistry and chemical engineering minimize waste and energy use, and eliminate toxic by-products. Given the ubiquitous nature of products from chemical processes in our lives, green chemistry and chemical engineering are vital components of any sustainable future. Gathering together ten peer-reviewed articles from ...

Synthesis of Heterocycles via Multicomponent Reactions II

Synthesis of Heterocycles via Multicomponent Reactions II
  • Author : Romano V. A. Orru,Eelco Ruijter
  • Publisher : Springer
  • Release Date : 2010-07-26
  • Total pages : 292
  • ISBN : 9780128193747
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Summary : Géraldine Masson, Luc Neuville ∙ Carine Bughin ∙ Aude Fayol ∙ Jieping Zhu Multicomponent Syntheses of Macrocycles Thomas J.J. Müller Palladium-Copper Catalyzed Alkyne Activation as an Entry to Multicomponent Syntheses of Heterocycles Rachel Scheffelaar ∙ Eelco Ruijter ∙ Romano V.A. Orru Multicomponent Reaction Design Strategies: Towards Scaffold and Stereochemical Diversity Nicola ...

Solid Supported Combinatorial and Parallel Synthesis of Small Molecular Weight Compound Libraries

Solid Supported Combinatorial and Parallel Synthesis of Small Molecular Weight Compound Libraries
  • Author : D. Obrecht,J.M. Villalgordo
  • Publisher : Elsevier
  • Release Date : 1998-10-02
  • Total pages : 338
  • ISBN : 9780128193747
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Summary : The words "Combinatorial Chemistry" have different meanings to different people, ranging from split and mix strategies to parallel synthesis using robots, and embracing the whole range of preparative chemistry from organic molecules, to catalyst ligands, and even inorganic solids. All of these activities have in common an attempt to expand ...