DNA Repair in Cancer Therapy

Written By Mark Kelley
DNA Repair in Cancer Therapy
  • Publsiher : Academic Press
  • Release : 05 July 2016
  • ISBN : 9780128035825
  • Pages : 464 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled DNA Repair in Cancer Therapy written by Mark Kelley which was release on 05 July 2016, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: "DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition" provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment. Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the inhibition of repair pathways can be coupled with chemotherapy, radiation, or DNA damaging drugs. Newer areas in this edition include the role of DNA repair in chemotherapy induced peripheral neuropathy, radiation DNA damage, Fanconi anemia cross-link repair, translesion DNA polymerases, BRCA1-BRCA2 pathway for HR and synthetic lethality, and mechanisms of resistance to clinical PARP inhibitors. Provides a comprehensive overview of the basic and translational research in DNA repair as a cancer therapeutic targetIncludes timely updates from the earlier edition, including Fanconi Anemia cross-link repair, translesion DNA polymerases, chemotherapy induced peripheral neuropathy, and many other new areas within DNA repair and cancer therapySaves academic, medical, and pharma researchers time by allowing them to quickly access the very latest details on DNA repair and cancer therapyAssists researchers and research clinicians in understanding the importance of the breakthroughs that are contributing to advances in disease-specific research

DNA Repair in Cancer Therapy

DNA Repair in Cancer Therapy
  • Author : Mark Kelley
  • Publisher : Academic Press
  • Release Date : 2016-07-05
  • Total pages : 464
  • ISBN : 9780128035825
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Summary : "DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition" provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment. Experts on DNA repair proteins ...

Advances in DNA Repair in Cancer Therapy

Advances in DNA Repair in Cancer Therapy
  • Author : Lawrence Panasci,Raquel Aloyz,Moulay Alaoui-Jamali
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-09
  • Total pages : 312
  • ISBN : 9780128035825
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Summary : ​A comprehensive review of the recent developments in DNA repair research that have potential for translational applications. The book explains in detail the various biological mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the impact of such novel inhibitors of ...

DNA Repair in Cancer Therapy

DNA Repair in Cancer Therapy
  • Author : Mark R. Kelley,Melissa L. Fishel
  • Publisher : Academic Press
  • Release Date : 2016-06-07
  • Total pages : 464
  • ISBN : 9780128035825
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Summary : DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment. Experts on DNA repair proteins ...

DNA Repair in Cancer Therapy

DNA Repair in Cancer Therapy
  • Author : Lawrence C. Panasci,Moulay A. Alaoui-Jamali
  • Publisher : Springer Science & Business Media
  • Release Date : 2004-03-19
  • Total pages : 363
  • ISBN : 9780128035825
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Summary : A comprehensive review of the recent developments in DNA repair that have potential for translational and clinical applications. The authors explain in detail the various mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the clinical impact of such novel inhibitors ...

DNA Repair and Cancer

DNA Repair and Cancer
  • Author : Srinivasan Madhusudan,David M. Wilson III
  • Publisher : CRC Press
  • Release Date : 2013-01-22
  • Total pages : 718
  • ISBN : 9780128035825
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Summary : DNA repair is a rapidly advancing field in biology and these systems represent a major defense mechanism against environmental and intracellular damaging agents such as sunlight, ionizing radiation, and reactive oxygen species. With contributions from eminent researchers, this book explores the basics and current trends in this critical field. Topics ...

Inhibition of RAD52 based DNA Repair for Cancer Therapy

Inhibition of RAD52 based DNA Repair for Cancer Therapy
  • Author : Mona Hadi Al-Mugotir
  • Publisher : Unknown
  • Release Date : 2018
  • Total pages : 172
  • ISBN : 9780128035825
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Summary : Germline BRCA mutations underlay a significant risk for breast and ovarian cancer that increases in age. BRCA mutations are usually associated with the most aggressive subtypes of these cancers such as triple negative breast cancer and high-grade serous ovarian cancer. Conventional chemotherapeutic or hormonal therapies do not address the molecular ...

Targeting the DNA Damage Response for Anti Cancer Therapy

Targeting the DNA Damage Response for Anti Cancer Therapy
  • Author : John Pollard,Nicola Curtin
  • Publisher : Springer
  • Release Date : 2018-05-26
  • Total pages : 401
  • ISBN : 9780128035825
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Summary : Over the past decade a complex role for DNA damage response (DDR) in tumorigenesis has emerged. A proficient DDR has been shown to be a primary cause for cellular resistance to the very many DNA damaging drugs, and IR, that are widely used as standard-of-care across multiple cancer types. It ...

PARP Inhibitors for Cancer Therapy

PARP Inhibitors for Cancer Therapy
  • Author : Nicola J. Curtin,Ricky A. Sharma
  • Publisher : Humana Press
  • Release Date : 2015-06-13
  • Total pages : 591
  • ISBN : 9780128035825
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Summary : PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP in cancer therapy. The volume covers the history of the discovery of PARP (poly ADP ribose polymerase) and its role in DNA repair. In addition, a description of discovery of the PARP family, and other DNA ...

System Biology Analysis of the Role of DNA Repair in Cancer Treatment Outcome

System Biology Analysis of the Role of DNA Repair in Cancer Treatment Outcome
  • Author : Mengdi Qian
  • Publisher : Unknown
  • Release Date : 2019
  • Total pages : 212
  • ISBN : 9780128035825
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Summary : Cancer is one of the most lethal and hard to cure diseases. The common treatments for cancer include surgery, radiation therapy, chemotherapy, immunotherapy and hormone therapy. Ionizing radiation (IR) is one of the main clinical treatments for cancer and it works by inducing DNA double strand breaks (DSBs), which are ...

The BRCA1 and BRCA2 Breast and Ovarian Cancer Susceptibility Genes Implications for DNA Damage Response DNA Repair and Cancer Therapy

The BRCA1 and BRCA2 Breast and Ovarian Cancer Susceptibility Genes   Implications for DNA Damage Response  DNA Repair and Cancer Therapy
  • Author : Katy S. Orr
  • Publisher : Unknown
  • Release Date : 2015
  • Total pages : 212
  • ISBN : 9780128035825
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Summary : The BRCA1 and BRCA2 Breast and Ovarian Cancer Susceptibility Genes - Implications for DNA Damage Response, DNA Repair and Cancer Therapy....

DNA Repair and Resistance to Cancer Therapy

DNA Repair and Resistance to Cancer Therapy
  • Author : António S. Rodrigues
  • Publisher : Unknown
  • Release Date : 2013
  • Total pages : 212
  • ISBN : 9780128035825
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Summary : DNA Repair and Resistance to Cancer Therapy....

A Novel DNA Damage Quantification Platform Enables High Throughput Screening for Genes that Impact DNA Double Strand Breaks

A Novel DNA Damage Quantification Platform Enables High Throughput Screening for Genes that Impact DNA Double Strand Breaks
  • Author : Ian Jun Jie Tay
  • Publisher : Unknown
  • Release Date : 2018
  • Total pages : 169
  • ISBN : 9780128035825
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Summary : DNA is the blueprint of life, and the high fidelity transmission of genetic information from parent cells to progeny is essential for an organism's viability. However, our genomes are constantly being damaged by reactive molecules generated from cellular metabolic processes or introduced from the environment. The resulting DNA damage can ...

Gene Therapy of Cancer

Gene Therapy of Cancer
  • Author : Edmund C. Lattime,Stanton L. Gerson
  • Publisher : Academic Press
  • Release Date : 2013-08-28
  • Total pages : 554
  • ISBN : 9780128035825
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Summary : Gene therapy as a treatment for cancer is at a critical point in its evolution. Exciting new developments in gene targeting and vector technology, coupled with results from the first generation of preclinical and clinical studies have led to the design and testing of new therapeutic approaches. The Third Edition ...

DNA Repair Cancer and Cancer Therapy

DNA Repair  Cancer and Cancer Therapy
  • Author : Mu Wang
  • Publisher : Unknown
  • Release Date : 2011
  • Total pages : 212
  • ISBN : 9780128035825
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Summary : Download or read online DNA Repair Cancer and Cancer Therapy written by Mu Wang, published by which was released on 2011. Get DNA Repair Cancer and Cancer Therapy Books now! Available in PDF, ePub and Kindle....

Checkpoint Responses in Cancer Therapy

Checkpoint Responses in Cancer Therapy
  • Author : Wei Dai
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-05-01
  • Total pages : 314
  • ISBN : 9780128035825
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Summary : Extensive research has uncovered a set of molecular surveillance mechanisms – commonly called “checkpoints” – which tightly monitor cell-cycle processes. Today’s anticancer drug development has identified many of these cell-cycle checkpoint molecules as effective targets. Research now promises to uncover a new generation of anticancer drugs with improved therapeutic indices based ...