Design of Hybrid Molecules for Drug Development

Written By Michael Decker
Design of Hybrid Molecules for Drug Development
  • Publsiher : Elsevier
  • Release : 05 April 2017
  • ISBN : 0081011180
  • Pages : 352 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Design of Hybrid Molecules for Drug Development written by Michael Decker which was release on 05 April 2017, this book published by Elsevier. Available in PDF, EPUB and Kindle Format. Book excerpt: Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules containing NO- and H2S-donors, dual-acting compounds acting as receptor ligands and enzyme inhibitors, and the design of photoresponsive drugs all discussed. Drawing on practical case studies, the hybridization of molecules for development as treatments for a number of key diseases is then outlined, including the design of hybrids for Alzheimer's, cancer, and malaria. With its cutting-edge reviews of breaking developments in this exciting field, the book offers a novel approach for all those working in the design, development, and administration of drugs for a range of debilitating disorders. Highlights an approach unimpaired by the limitations of the classical search for lead structures - one of the core problems in modern drug development processes, making the content of high relevance for both academic and non-academic drug development processes Pulls together research and design techniques in a novel way to give researchers the best possible platform from which to review the approaches and techniques applied Compares the advantages and disadvantages of these compounds Includes the very latest developments, such as photoactivatable and photo-responsive drugs

Design of Hybrid Molecules for Drug Development

Design of Hybrid Molecules for Drug Development
  • Author : Michael Decker
  • Publisher : Elsevier
  • Release Date : 2017-04-05
  • Total pages : 352
  • ISBN : 0081011180
GET BOOK

Summary : Design of Hybrid Molecules for Drug Development reviews the principles, advantages, and limitations involved with designing these groundbreaking compounds. Beginning with an introduction to hybrid molecule design and background as to their need, the book goes on to explore a range of important hybrids, with hybrids containing natural products, molecules ...

Multiple Action Based Design Approaches to Antibacterials

Multiple Action Based Design Approaches to Antibacterials
  • Author : John Bremner
  • Publisher : Springer Nature
  • Release Date : 2021-04-05
  • Total pages : 193
  • ISBN : 0081011180
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Summary : This book covers intentional design aspects for combinations of drugs, single-molecule hybrids with potential or actual multiple actions, pro-drugs which could yield multiple activity outcomes, and future possibilities. The approach of the book is interdisciplinary, and it provides greater understanding of the complex interplay of factors involved in the medicinal ...

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Polypharmacology in Drug Discovery
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  • Publisher : John Wiley & Sons
  • Release Date : 2012-01-20
  • Total pages : 536
  • ISBN : 0081011180
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Summary : An essential outline of the main facets of polypharmacology indrug discovery research Extending drug discovery opportunities beyond the "one drug, onetarget" philosophy, a polypharmacological approach to the treatmentof complex diseases is emerging as a hot topic in both industry andacademic research. Polypharmacology in Drug Discovery presents anoverview of the various ...

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Chemical Drug Design
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  • Publisher : Walter de Gruyter GmbH & Co KG
  • Release Date : 2016-10-10
  • Total pages : 297
  • ISBN : 0081011180
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Summary : Chemical Drug Design provides a compact overview on recent advances in this rapidly developing field. With contributions on in silico drug design, natural product based compounds, as well as on ligand- and structure-based approaches, the authors present innovative methods and techniques for identifying and synthetically designing novel drugs....

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Advances in Heterocyclic Chemistry
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-03-19
  • Total pages : 437
  • ISBN : 0081011180
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Summary : Advances in Heterocyclic Chemistry, Volume 129 is the definitive series in the field—one of great importance to organic chemists, polymer chemists and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field ...

Identification of Multiple Targets in the Fight against Alzheimer s Disease

Identification of Multiple Targets in the Fight against Alzheimer   s Disease
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  • Publisher : Frontiers Media SA
  • Release Date : 2020-07-31
  • Total pages : 212
  • ISBN : 0081011180
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Summary : Download or read online Identification of Multiple Targets in the Fight against Alzheimer s Disease written by Patrizia Giannoni,Silvia Fossati,Sylvie Claeysen,Elena Marcello, published by Frontiers Media SA which was released on 2020-07-31. Get Identification of Multiple Targets in the Fight against Alzheimer s Disease Books now! ...

Computational Medicinal Chemistry for Drug Discovery

Computational Medicinal Chemistry for Drug Discovery
  • Author : Patrick Bultinck,Hans De Winter,Wilfried Langenaeker,Jan P. Tollenare
  • Publisher : CRC Press
  • Release Date : 2003-12-17
  • Total pages : 1169
  • ISBN : 0081011180
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Summary : Observing computational chemistry's proven value to the introduction of new medicines, this reference offers the techniques most frequently utilized by industry and academia for ligand design. Featuring contributions from more than fifty pre-eminent scientists, Computational Medicinal Chemistry for Drug Discovery surveys molecular structure computation, intermolecular behavior, ligand-receptor interaction, and modeling ...

Development of Hybrid Drugs for Cancer Treatment and Studies in Asymmetric Organocatalysis

Development of Hybrid Drugs for Cancer Treatment and Studies in Asymmetric Organocatalysis
  • Author : Dainis Kaldre
  • Publisher : Unknown
  • Release Date : 2016
  • Total pages : 212
  • ISBN : 0081011180
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Summary : "This thesis is separated into two parts. In the first part design, synthesis and structure-activity relationships of the novel Vitamin D receptor (VDR) agonists and histone deacetylase (HDAC) inhibitors are presented. In the second part, the development of a new methodology to accelerate [3,3] sigmatropic rearrangements is presented.A promising approach ...

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  • Author : Norbert Handler,Helmut Buschmann,Raimund Mannhold,Jörg Holenz
  • Publisher : John Wiley & Sons
  • Release Date : 2018-02-05
  • Total pages : 536
  • ISBN : 0081011180
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Summary : The book provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. ...

In Silico Drug Discovery and Design

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  • Author : Claudio N. Cavasotto
  • Publisher : CRC Press
  • Release Date : 2015-08-06
  • Total pages : 558
  • ISBN : 0081011180
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Summary : In Silico Drug Discovery and Design: Theory, Methods, Challenges, and Applications provides a comprehensive, unified, and in-depth overview of the current methodological strategies in computer-aided drug discovery and design. Its main aims are to introduce the theoretical framework and algorithms, discuss the range of validity, strengths and limita...

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  • Author : Bhima Bhukya,Anjana Devi Tangutur
  • Publisher : CRC Press
  • Release Date : 2017-03-16
  • Total pages : 448
  • ISBN : 0081011180
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Summary : The new volume takes an interdisciplinary look at current technical challenges and recent developmental trends in microbial biotechnology. It covers an avalanche of new information available through research by focusing on a broad spectrum of issues on different microorganisms and their recent applications and implications in agriculture, soil science and ...

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  • Author : Anonim
  • Publisher : ScholarlyEditions
  • Release Date : 2013-01-10
  • Total pages : 245
  • ISBN : 0081011180
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Summary : Issues in Medical Chemistry / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Medicinal Chemistry. The editors have built Issues in Medical Chemistry: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Medicinal Chemistry in this eBook to be deeper than ...

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  • Author : M. R. Yadav,P. R. Murumkar,R. B. Ghuge
  • Publisher : Elsevier
  • Release Date : 2018-03-14
  • Total pages : 430
  • ISBN : 0081011180
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Summary : Vicinal Diaryl-Substituted Heterocycles: A Gold Mine for the Discovery of Novel Therapeutic Agents draws together all of the key information about these compounds in one place for the first time. Following an informative overview of the importance of these structures to the discovery of potential therapeutic agents, the text goes ...

Antibiotic Materials in Healthcare

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  • Author : Kokkarachedu Varaprasad,Vimala Kanikireddy,Rotimi Sadiku
  • Publisher : Academic Press
  • Release Date : 2020-05-22
  • Total pages : 346
  • ISBN : 0081011180
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Summary : Antibiotic Materials in Healthcare provides significant information on antibiotic related issues, accurate solutions, and recent investigative information for health-related applications. In addition, the book addresses the design and development of antibiotics with advanced (physical, chemical and biological) properties, an analysis of materials, in vivo and in vitro applications, and their ...

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  • Publisher : Academic Press
  • Release Date : 2015-11-19
  • Total pages : 498
  • ISBN : 0081011180
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Summary : Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found ...