Cellular and Animal Models in Human Genomics Research

Written By Anonim
Cellular and Animal Models in Human Genomics Research
  • Publsiher : Academic Press
  • Release : 30 July 2019
  • ISBN : 012816574X
  • Pages : 226 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Cellular and Animal Models in Human Genomics Research written by Anonim which was release on 30 July 2019, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn lists of plausible genes into causative biomarkers. With chapters written by international experts, the book first addresses the fundamental aspects of using cellular and animal models in genetic and genomic studies, including in-depth examples of specific models and their utility, i.e., yeast, worms, flies, fish, mice and large animals. Protocols for properly conducting model studies, genomic technology, modeling candidate genes vs. genetic variants, integrative modeling, utilizing induced pluripotent stem cells, and employing CRISPR-Cas9 are also discussed in-depth. Provides a thorough, accessible resource that helps researchers and students employ cellular and animal models in their own genetic and genomic studies Offers guidance on how to effectively interpret the results and significance of genetic and genomic model studies for human health Features chapters from international experts in the use of specific cellular and animal models, including yeast, worms, flies, fish, mice, and large animals, among other organisms

Cellular and Animal Models in Human Genomics Research

Cellular and Animal Models in Human Genomics Research
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2019-07-30
  • Total pages : 226
  • ISBN : 012816574X
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Summary : Cellular and Animal Models in Human Genomics Research provides an indispensable resource for applying comparative genomics in the annotation of disease-gene associated variants that are identified by human genomic sequencing. The book presents a thorough overview of effective protocols for the use of cellular and animal modeling methods to turn ...

Cancer Genomics

Cancer Genomics
  • Author : Jason N. Berman,Priscilla P.L. Chiu,Graham Dellaire
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-11-21
  • Total pages : 510
  • ISBN : 012816574X
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Summary : Genome-wide association (GWA) studies and tumor-specific epigenome, transcriptome and genome sequencing projects are generating an ever-growing list of susceptibility alleles, as well as putative gain- and loss-of-function gene mutations associated with cancer. These genetic changes ultimately need to be validated to determine their contribution to the initiation, progression and likelihood ...

Animal Models and Human Reproduction

Animal Models and Human Reproduction
  • Author : Heide Schatten,Gheorghe M. Constantinescu
  • Publisher : John Wiley & Sons
  • Release Date : 2017-01-13
  • Total pages : 600
  • ISBN : 012816574X
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Summary : Our knowledge of reproductive biology has increased enormously in recent years on cellular, molecular, and genetic levels, leading to significant breakthroughs that have directly benefitted in vitro fertilization (IVF) and other assisted reproductive technologies (ART) in humans and animal systems. Animal Models and Human Reproduction presents a comprehensive reference that ...

Animal Biotechnology

Animal Biotechnology
  • Author : Ashish S. Verma,Anchal Singh
  • Publisher : Academic Press
  • Release Date : 2020-06-11
  • Total pages : 798
  • ISBN : 012816574X
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Summary : Animal Biotechnology: Models in Discovery and Translation, Second Edition, provides a helpful guide to anyone seeking a thorough review of animal biotechnology and its application to human disease and welfare. This updated edition covers vital fundamentals, including animal cell cultures, genome sequencing analysis, epigenetics and animal models, gene expression, and ...

CRISPR in Animals and Animal Models

CRISPR in Animals and Animal Models
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2017-11-10
  • Total pages : 148
  • ISBN : 012816574X
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Summary : CRISPR in Animals and Animal Models, Volume 152, the latest release in the Progress in Molecular Biology and Translational Science series, explores the genome editing CRISPR system in cells and animal models, its applications, the uses of the CRISPR system, and the past, present and future of CRISPR genome editing. Topics ...

Mouse Models of Human Cancer

Mouse Models of Human Cancer
  • Author : Eric C. Holland
  • Publisher : Wiley-Liss
  • Release Date : 2004-08-27
  • Total pages : 488
  • ISBN : 012816574X
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Summary : Mice have become the species of choice for modeling the complex interactions between tumor cells and the host environment. Mouse genetics are easily manipulated, and a growing array of technology exists for this purpose. Mouse models allow investigators to better understand causal relationships between specific genetic alterations and tumors, utilize ...

Handbook of Models for Human Aging

Handbook of Models for Human Aging
  • Author : P. Michael Conn
  • Publisher : Elsevier
  • Release Date : 2011-04-28
  • Total pages : 1075
  • ISBN : 012816574X
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Summary : The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of ...

Animal Models in Biomedical Research

Animal Models in Biomedical Research
  • Author : Cynthia Petrie Smith
  • Publisher : Unknown
  • Release Date : 1992
  • Total pages : 80
  • ISBN : 012816574X
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Summary : Download or read online Animal Models in Biomedical Research written by Cynthia Petrie Smith, published by which was released on 1992. Get Animal Models in Biomedical Research Books now! Available in PDF, ePub and Kindle....

From Animal Models to Human Genetics

From Animal Models to Human Genetics
  • Author : Karsten Conrad
  • Publisher : Unknown
  • Release Date : 2004
  • Total pages : 611
  • ISBN : 012816574X
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Summary : Download or read online From Animal Models to Human Genetics written by Karsten Conrad, published by which was released on 2004. Get From Animal Models to Human Genetics Books now! Available in PDF, ePub and Kindle....

Animal Models of Speech and Language Disorders

Animal Models of Speech and Language Disorders
  • Author : Santosh A. Helekar
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-10-17
  • Total pages : 295
  • ISBN : 012816574X
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Summary : Basic research over the last decade or two has uncovered similarities between speech, especially its sensori-motor aspects, and vocal communication in several non-human species. The most comprehensive studies so far have been conducted in songbirds. Songbirds offer us a model system to study the interactions between developmental or genetic predispositions ...

Mouse Models of Human Blood Cancers

Mouse Models of Human Blood Cancers
  • Author : Shaoguang Li
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-12-19
  • Total pages : 293
  • ISBN : 012816574X
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Summary : In this book, Dr. Li and his author team plan to emphasize why mouse models are useful in vivo systems for understanding disease mechanisms and developing therapeutic strategies in blood cancers. The authors do not intend to cover all types of blood cancers; instead, they will focus on some major ...

CRISPR in Animals and Animal Models

CRISPR in Animals and Animal Models
  • Author : Raul Torres-Ruiz,Sandra Rodriguez-Perales
  • Publisher : Academic Press
  • Release Date : 2017-11
  • Total pages : 148
  • ISBN : 012816574X
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Summary : CRISPR in Animals and Animal Models, Volume 152, the latest release in the Progress in Molecular Biology and Translational Science series, explores the genome editing CRISPR system in cells and animal models, its applications, the uses of the CRISPR system, and the past, present and future of CRISPR genome editing. Topics ...

What Will We Do If We Don t Experiment on Animals

What Will We Do If We Don t Experiment on Animals
  • Author : Jean Swingle Greek,C. Ray Greek
  • Publisher : Trafford Publishing
  • Release Date : 2004
  • Total pages : 261
  • ISBN : 012816574X
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Summary : Drs. Greek have written 2 books on why using animals as models for humans is not the best way to conduct medical research and drug testing. During their lectures and debates, the most commonly asked question was, "Well. What will we use if we don't use animals?" What Will We Do ...

Animal Models for Human Cancer Volume 69

Animal Models for Human Cancer  Volume 69
  • Author : Marianne I. Martic-Kehl,Pius August Schubiger,Raimund Mannhold,Hugo Kubinyi,Gerd Folkers
  • Publisher : John Wiley & Sons
  • Release Date : 2016-08-15
  • Total pages : 272
  • ISBN : 012816574X
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Summary : Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results. Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the ...

An Introduction to Molecular Medicine and Gene Therapy

An Introduction to Molecular Medicine and Gene Therapy
  • Author : Thomas F. Kresina
  • Publisher : John Wiley & Sons
  • Release Date : 2004-04-07
  • Total pages : 416
  • ISBN : 012816574X
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Summary : Gene therapy, or the use of genetic manipulation for diseasetreatment, is derived from advances in genetics, molecular biology,clinical medicine, and human genomics. Molecular medicine, theapplication of molecular biological techniques to disease treatmentand diagnosis, is derived from the development of human organtransplantation, pharmacotherapy, and elucidation of the humangenome. An Introduction ...