The Carbonic Anhydrases

Written By W.R. Chegwidden
The Carbonic Anhydrases
  • Publsiher : Birkhäuser
  • Release : 11 November 2013
  • ISBN : 303488446X
  • Pages : 619 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled The Carbonic Anhydrases written by W.R. Chegwidden which was release on 11 November 2013, this book published by Birkhäuser. Available in PDF, EPUB and Kindle Format. Book excerpt: Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), has found favour as a model for the study of evolution of gene families and for site-directed mutagenesis in structure/function relationships, for protein folding and for transgenic and gene target studies. Since the early use of CA inhibitors as diuretics and in treating congestive heart failure, the enzyme has been target of considerable clinical attention. Much of this is now focused on endeavours to produce a new generation of such drugs for the effective treatment of glaucoma and other potential applications. Recent data, suggesting links between CA and various disease processes, including cancer, have stimulated further...

The Carbonic Anhydrases

The Carbonic Anhydrases
  • Author : W.R. Chegwidden,N.D. Carter,Y.H. Edwards
  • Publisher : Birkhäuser
  • Release Date : 2013-11-11
  • Total pages : 619
  • ISBN : 303488446X
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Summary : Carbonic anhydrase (CA) is a seemingly ubiquitous enzyme of profound physiological importance, which plays essential roles in respiration, acid-base homeostasis, bone resorption, calcification, photosynthesis, several biosynthetic pathways and a variety of processes involving ion, gas and fluid transfer. This enzyme, which is present in at least three gene families (a, ß, ?), ...

Carbonic Anhydrases as Biocatalysts

Carbonic Anhydrases as Biocatalysts
  • Author : Claudiu T Supuran,Giuseppina De Simone
  • Publisher : Elsevier
  • Release Date : 2015-01-14
  • Total pages : 398
  • ISBN : 303488446X
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Summary : Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, present throughout most living organisms and encoded by five evolutionarily unrelated gene families. The Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications presents information on the growing interest in the study of this enzyme family and their applications to both ...

Carbonic Anhydrases

Carbonic Anhydrases
  • Author : Claudiu T. Supuran,Alessio Nocentini
  • Publisher : Academic Press
  • Release Date : 2019-07-17
  • Total pages : 560
  • ISBN : 303488446X
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Summary : Carbonic Anhydrases provides an interdisciplinary review of the burgeoning carbonic anhydrase (CA) research area, spanning from CAs classification (biochemical and structural features) to drug design and pharmacology of CA inhibitors and activators, finally touching on the biotechnological applications of these metalloenzymes. The book adopts a clear step-by-step approach and introduction ...

The Carbonic Anhydrases Current and Emerging Therapeutic Targets

The Carbonic Anhydrases  Current and Emerging Therapeutic Targets
  • Author : W. Richard Chegwidden,Nicholas D. Carter
  • Publisher : Springer
  • Release Date : 2021-11-27
  • Total pages : 288
  • ISBN : 303488446X
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Summary : This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both ...

The Carbonic Anhydrases

The Carbonic Anhydrases
  • Author : N.D. Carter,S.J. Dodgson,G. Gros,R.E. Tashian
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-06-29
  • Total pages : 380
  • ISBN : 303488446X
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Summary : As we approach the twenty-first century the problems of industrialization are evident: we find there is a greenhouse effect, the ozone layer is being depleted, the rain is acidified, and there is a terrible problem of increasing C0 concentrations in the atmo 2 sphere. The carbonic anhydrases are a unique family ...

Carbonic Anhydrases and Metabolism

Carbonic Anhydrases and Metabolism
  • Author : Claudiu T. Supuran
  • Publisher : MDPI
  • Release Date : 2019-04-08
  • Total pages : 184
  • ISBN : 303488446X
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Summary : Carbonic anhydrases (CAs; EC 4.2.1.1) are metalloenzymes present in all kingdoms of life, as they equilibrate the reaction between three simple but essential chemical species: CO2, bicarbonate, and protons. Discovered more than 80 years ago, in 1933, these enzymes have been extensively investigated due to the biomedical application of their inhibitors, but also ...

Primary Structural Studies of Horse Carbonic Anhydrases

Primary Structural Studies of Horse Carbonic Anhydrases
  • Author : Robert Paul Bray
  • Publisher : Unknown
  • Release Date : 1977
  • Total pages : 418
  • ISBN : 303488446X
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Summary : Download or read online Primary Structural Studies of Horse Carbonic Anhydrases written by Robert Paul Bray, published by which was released on 1977. Get Primary Structural Studies of Horse Carbonic Anhydrases Books now! Available in PDF, ePub and Kindle....

Carbonic Anhydrases

Carbonic Anhydrases
  • Author : Joni Penttinen
  • Publisher : Unknown
  • Release Date : 2018
  • Total pages : 212
  • ISBN : 303488446X
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Summary : Download or read online Carbonic Anhydrases written by Joni Penttinen, published by which was released on 2018. Get Carbonic Anhydrases Books now! Available in PDF, ePub and Kindle....

Studies of Human and Bacterial Carbonic Anhydrases and a Carbonic Anhydrase related Protein CARP

Studies of Human and Bacterial Carbonic Anhydrases and a Carbonic Anhydrase related Protein  CARP
  • Author : Björn Elleby
  • Publisher : Unknown
  • Release Date : 2000
  • Total pages : 45
  • ISBN : 303488446X
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Summary : Download or read online Studies of Human and Bacterial Carbonic Anhydrases and a Carbonic Anhydrase related Protein CARP written by Björn Elleby, published by which was released on 2000. Get Studies of Human and Bacterial Carbonic Anhydrases and a Carbonic Anhydrase related Protein CARP Books now! Available in PDF, ePub ...

The Carbonic Anhydrases

The Carbonic Anhydrases
  • Author : S.J. Dodgson,N.D. Carter,G. Gros,R.E. Tashian
  • Publisher : Springer Science & Business Media
  • Release Date : 1991-05-31
  • Total pages : 379
  • ISBN : 303488446X
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Summary : As we approach the twenty-first century the problems of industrialization are evident: we find there is a greenhouse effect, the ozone layer is being depleted, the rain is acidified, and there is a terrible problem of increasing C0 concentrations in the atmo 2 sphere. The carbonic anhydrases are a unique family ...

The Carbonic Anhydrases Current and Emerging Therapeutic Targets

The Carbonic Anhydrases  Current and Emerging Therapeutic Targets
  • Author : W. Richard Chegwidden,Nicholas D. Carter
  • Publisher : Springer Nature
  • Release Date : 2021-12-01
  • Total pages : 288
  • ISBN : 303488446X
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Summary : This volume assembles and integrates the wealth of diverse information that is now accumulating in this burgeoning field. The existing and potential therapeutic applications of targeting CA cover a remarkably wide-range of diseases and disorders and have generated increasing and extensive interest in recent years. Its inter-disciplinary approach embraces both ...

Chemically Modified Carbonic Anhydrases Useful in Carbon Capture Systems

Chemically Modified Carbonic Anhydrases Useful in Carbon Capture Systems
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2013
  • Total pages : 212
  • ISBN : 303488446X
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Summary : The present disclosure relates to chemically modified carbonic anhydrase polypeptides and soluble compositions, homogenous liquid formulations comprising them. The chemically modified carbonic anhydrase polypeptides have improved properties relative to the same carbonic anhydrase polypeptide that is not chemically modified including the improved properties of increased activity and/or stability in ...

Carbonic Anhydrase

Carbonic Anhydrase
  • Author : Claudiu T. Supuran,Andrea Scozzafava,Janet Conway
  • Publisher : CRC Press
  • Release Date : 2004-05-27
  • Total pages : 376
  • ISBN : 303488446X
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Summary : Carbonic Anhydrase: Its Inhibitors and Activators provides a state-of-the-art overview of the latest developments and challenges in carbonic anhydrase research. Authors describe the mechanisms of action of specific inhibitors in relation to physiological function, and present previously unpublished research on CA activators. Written by a team of internationally recognized experts, ...

Highly Stable Beta class Carbonic Anhydrases Useful in Carbon Capture Systems

Highly Stable Beta class Carbonic Anhydrases Useful in Carbon Capture Systems
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2013
  • Total pages : 212
  • ISBN : 303488446X
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Summary : The present disclosure relates to .beta.-class carbonic anhydrase polypeptides having improved properties including increased thermostability and/or stability in the presence of amine compounds, ammonia, or carbonate ion. The present disclosure also provides formulations and uses of the polypeptides for accelerating the absorption of carbon dioxide from a gas ...

Carbonic Anhydrase Mechanism Regulation Links to Disease and Industrial Applications

Carbonic Anhydrase  Mechanism  Regulation  Links to Disease  and Industrial Applications
  • Author : Susan C. Frost,Robert McKenna
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-10-22
  • Total pages : 430
  • ISBN : 303488446X
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Summary : The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA ...