Cancer Stem Cells in Solid Tumors

Written By Alison L. Allan
Cancer Stem Cells in Solid Tumors
  • Publsiher : Springer Science & Business Media
  • Release : 12 August 2011
  • ISBN : 1617792462
  • Pages : 478 pages
  • Rating : 5/5 from 1 reviews
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Read or download book entitled Cancer Stem Cells in Solid Tumors written by Alison L. Allan which was release on 12 August 2011, this book published by Springer Science & Business Media. Available in PDF, EPUB and Kindle Format. Book excerpt: The “cancer stem cell” hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical role of stem cells in hematological malignancies and suggested that these same mechanisms are also central to the initiation, progression, and treatment of solid cancers. Clinical and experimental studies have shown that CSCs exhibit many classical properties of normal stem cells, including a high self-renewal capacity and the ability to generate heterogeneous lineages; the requirement for a specific “niche”/microenvironment to grow; and an increased capacity for self-protection against harsh environments, toxins, and drugs. Cancer Stem Cells in Solid Tumors represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume will provide readers with a comprehensive understanding of this important and evolving field. Topics covered include: Introduction of the CSC hypothesis Historical perspectives and the contributing lessons from leukemia Current knowledge regarding the identification and role of CSCs in various forms of solid cancer including breast, brain, colorectal, pancreatic, prostate, melanoma, lung, ovarian, hepatocellular, and head and neck cancer Molecular pathways involved in driving CSC function, with a particular focus on the novel convergence of embryonic and tumorigenic signaling pathways In vitro and in vivo assays, model systems, and imaging modalities for studying CSCs The clinical importance of CSCs for cancer management and treatment, including important implications for prognosis, prediction, and treatment resistance Consideration of the controversy surrounding the CSC hypothesis and important unanswered questions in this field This collective work was written by a group of prominent international experts in cancer biology, oncology, and/or stem cell biology. It will serve as a valuable resource for established researchers, professors, health care professionals, and students in the medical and scientific community who are investigating stem cells and/or oncology.

Cancer Stem Cells

Cancer Stem Cells
  • Author : Stanley Shostak
  • Publisher : BoD – Books on Demand
  • Release Date : 2011-08-01
  • Total pages : 632
  • ISBN : 1617792462
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Summary : Over the last thirty years, the foremost inspiration for research on metastasis, cancer recurrence, and increased resistance to chemo- and radiotherapy has been the notion of cancer stem cells.The twenty-eight chapters assembled in Cancer Stem Cells - The Cutting Edge summarize the work of cancer researchers and oncologists at ...

Cancer Stem Cells in Solid Tumors

Cancer Stem Cells in Solid Tumors
  • Author : Alison L. Allan
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-08-12
  • Total pages : 478
  • ISBN : 1617792462
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Summary : The “cancer stem cell” hypothesis postulates that cancer arises from a subpopulation of tumor-initiating cells or cancer stem cells (CSCs). While the idea of cancer stem cells has been around for more than a hundred years, evidence from the fields of hematology and cancer biology has now demonstrated the critical ...

Role of Cancer Stem Cells in Cancer Biology and Therapy

Role of Cancer Stem Cells in Cancer Biology and Therapy
  • Author : Thomas Dittmar,Kurt S. Zänker
  • Publisher : CRC Press
  • Release Date : 2013-03-01
  • Total pages : 332
  • ISBN : 1617792462
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Summary : This book summarizes the latest findings about the role of cancer stem cells (CSCs) in cancer biology and how this knowledge could be used for novel anticancer therapies. It provides an overview of CSCs in selected malignancies with particular emphasis on hematopoietic neoplasias. It then reviews the role of CSCs ...

Stem Cells and Cancer Stem Cells Volume 1

Stem Cells and Cancer Stem Cells  Volume 1
  • Author : M.A. Hayat
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-10-12
  • Total pages : 200
  • ISBN : 1617792462
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Summary : Difference between tissue specific stem cells and embryonic stem cells is explained. The advantages of the latter are included. The application of human pluripotent stem cells, mesenchymal stem cells, and hematopoietic stem cells in cancer therapy and tissue/organ regeneration is detailed. Role of neural cancer stem cells in brain ...

Stem Cells and Cancer Stem Cells Volume 3

Stem Cells and Cancer Stem Cells Volume 3
  • Author : M.A. Hayat
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-11-22
  • Total pages : 400
  • ISBN : 1617792462
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Summary : It is pointed out that cancer stem cell is a cell type within a tumor that possesses the capacity of cell-renewal and can give rise to the heterogeneous lineages of cancer cells that comprise the tumor. It is emphasized that a cancer stem cell is a tumor initiating cell. That ...

Advances in Cancer Stem Cell Biology

Advances in Cancer Stem Cell Biology
  • Author : Roberto Scatena,Alvaro Mordente,Bruno Giardina
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-10-06
  • Total pages : 343
  • ISBN : 1617792462
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Summary : In recent years, cancer stem cells have been recognized as important component in carcinogenesis and they seem to form the basis of many (if not all) tumor types. Cancer stem cells or "cancer cell like stem cells" have been isolated from various cancers of different origin (blood, breast, brain, skin, ...

Stem Cells and Cancer Stem Cells Volume 4

Stem Cells and Cancer Stem Cells  Volume 4
  • Author : M.A. Hayat
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-02-07
  • Total pages : 319
  • ISBN : 1617792462
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Summary : Vast therapeutic applications of the following specific stem cells in disease and tissue injury are discussed: embryonic stem cells, induced pluripotent stem cells, human hair follicle stem cells, bone marrow-derived human mesenchymal stem cells, adipose-derived stem cells, periodontal/progenitor cells, cancer stem cells, and breast cancer stem cells. Because human ...

Stem Cells and Cancer Stem Cells Volume 7

Stem Cells and Cancer Stem Cells  Volume 7
  • Author : M.A. Hayat
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-06-12
  • Total pages : 278
  • ISBN : 1617792462
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Summary : The seventh in Springer’s landmark series of edited volumes on one of the highest-profile subjects in contemporary medicine and scientific endeavour, this volume sets out to cover a staggering range of research into the medical applications of stem cell research. While stem cells are the very stuff of life ...

Stem Cells and Cancer Stem Cells Volume 9

Stem Cells and Cancer Stem Cells  Volume 9
  • Author : M.A. Hayat
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-12-22
  • Total pages : 332
  • ISBN : 1617792462
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Summary : This fresh addition to the rapidly expanding Springer series on stem cells represents an additional forward step in our understanding of the causes, diagnosis, and cell-related therapies of major human diseases as well as debilitating injuries to human tissue and organs. Showcasing the work of more than 80 contributors from 13 nations, ...

Principles of Stem Cell Biology and Cancer

Principles of Stem Cell Biology and Cancer
  • Author : Tarik Regad,Thomas Sayers,Robert Rees
  • Publisher : John Wiley & Sons
  • Release Date : 2015-04-01
  • Total pages : 376
  • ISBN : 1617792462
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Summary : Principles of Stem Cell Biology and Cancer: Future Applications and Therapeutics Tarik Regad, The John van Geest Cancer Research Centre, Nottingham Trent University, UK, Thomas J. Sayers, Centre for Cancer Research, National Cancer Institute, Frederick, USA and Robert Rees The John van Geest Cancer Research Centre, Nottingham Trent University, UK ...

Stem Cells and Cancer Stem Cells Volume 12

Stem Cells and Cancer Stem Cells  Volume 12
  • Author : M.A. Hayat
  • Publisher : Springer Science & Business Media
  • Release Date : 2014-02-20
  • Total pages : 256
  • ISBN : 1617792462
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Summary : Volume 12 in this series explores the latest experimental and clinical uses of stem cells in the treatment of disease and of injuries and reviews methods for isolating multipotent endothelial-like cells from human adipose tissue and discusses clinical applications in cell therapy and regenerative medicine. The book is organized in five ...

Stem Cells and Cancer Stem Cells Volume 5

Stem Cells and Cancer Stem Cells  Volume 5
  • Author : M.A. Hayat
  • Publisher : Springer Science & Business Media
  • Release Date : 2012-02-22
  • Total pages : 309
  • ISBN : 1617792462
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Summary : It is pointed out that a cancer stem cell is a type within a tumor that possesses the capacity of self-renewal and can give rise to the heterogeneous lineages of cancer cells, which comprise the tumor. It is emphasized that a unique feature of cancer stem cells is that, although ...

Cancer Stem Cells

Cancer Stem Cells
  • Author : Sharmila A. Bapat
  • Publisher : John Wiley & Sons
  • Release Date : 2008-10-03
  • Total pages : 276
  • ISBN : 1617792462
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Summary : Because the concept and discoveries of cancer stem cells are relatively new, scientists and researchers need an introduction to this dynamic area. Cancer Stem Cells presents a consolidated account of the research done to date and recent progresses in the studies of cancer stem cells. Such a presentation facilitates a ...

Stem Cells and Cancer Stem Cells Volume 2

Stem Cells and Cancer Stem Cells  Volume 2
  • Author : M.A. Hayat
  • Publisher : Springer Science & Business Media
  • Release Date : 2011-10-17
  • Total pages : 384
  • ISBN : 1617792462
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Summary : As in volume 1 of this series, this volume presents information on stem cells and cancer stem cells; Therapeutic Applications in disease and tissue/organ injury. Methodologies of regenerative medicine and tissue engineering are major components of this volume. Specific stem cells discussed are: human embryonic stem cells, hematopoietic stem cells, ...

Stem Cells in Cancer Should We Believe or Not

Stem Cells in Cancer  Should We Believe or Not
  • Author : Enrique Grande,Luis Antón Aparicio
  • Publisher : Springer Science & Business
  • Release Date : 2014-04-28
  • Total pages : 299
  • ISBN : 1617792462
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Summary : This volume explores the latest developments in a novel area of molecular biology and a hot topic in the field of oncology: cancer stem cells. These chapters from expert contributing authors present concepts such as the universal stem cell, new molecular pathways, new targeted agents, the different roles that cancer ...