Mass Spectrometry in Biophysics

Written By Igor A. Kaltashov
Mass Spectrometry in Biophysics
  • Publsiher : John Wiley & Sons
  • Release : 06 May 2005
  • ISBN : 0471705160
  • Pages : 320 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Mass Spectrometry in Biophysics written by Igor A. Kaltashov which was release on 06 May 2005, this book published by John Wiley & Sons. Available in PDF, EPUB and Kindle Format. Book excerpt: The first systematic summary of biophysical mass spectrometrytechniques Recent advances in mass spectrometry (MS) have pushed the frontiersof analytical chemistry into the biophysical laboratory. As aresult, the biophysical community's acceptance of MS-based methods,used to study protein higher-order structure and dynamics, hasaccelerated the expansion of biophysical MS. Despite this growing trend, until now no single text has presentedthe full array of MS-based experimental techniques and strategiesfor biophysics. Mass Spectrometry in Biophysics expertly closesthis gap in the literature. Covering the theoretical background and technical aspects of eachmethod, this much-needed reference offers an unparalleled overviewof the current state of biophysical MS. Mass Spectrometry inBiophysics begins with a helpful discussion of general biophysicalconcepts and MS-related techniques. Subsequent chaptersaddress: * Modern spectrometric hardware * High-order structure and dynamics as probed by various MS-basedmethods * Techniques used to study structure and behavior of non-nativeprotein states that become populated under denaturingconditions * Kinetic aspects of protein folding and enzyme catalysis * MS-based methods used to extract quantitative information onprotein-ligand interactions * Relation of MS-based techniques to other experimental tools * Biomolecular properties in the gas phase Fully referenced and containing a helpful appendix on the physicsof electrospray mass spectrometry, Mass Spectrometry in Biophysicsalso offers a compelling look at the current challenges facingbiomolecular MS and the potential applications that will likelyshape its future.

Mass Spectrometry in Biophysics

Mass Spectrometry in Biophysics
  • Author : Igor A. Kaltashov,Stephen J. Eyles
  • Publisher : John Wiley & Sons
  • Release Date : 2005-05-06
  • Total pages : 320
  • ISBN : 0471705160
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Summary : The first systematic summary of biophysical mass spectrometrytechniques Recent advances in mass spectrometry (MS) have pushed the frontiersof analytical chemistry into the biophysical laboratory. As aresult, the biophysical community's acceptance of MS-based methods,used to study protein higher-order structure and dynamics, hasaccelerated the expansion of biophysical MS. Despite this growing ...

Mass Spectrometry in Structural Biology and Biophysics

Mass Spectrometry in Structural Biology and Biophysics
  • Author : Igor A. Kaltashov,Stephen J. Eyles
  • Publisher : John Wiley & Sons
  • Release Date : 2012-04-03
  • Total pages : 289
  • ISBN : 0471705160
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Summary : With its detailed and systematic coverage of the current state of biophysical mass spectrometry (MS), here is one of the first systematic presentations of the full experimental array of MS-based techniques used in biophysics, covering both fundamental and practical issues. The book presents a discussion of general biophysical concepts and ...

Development and Application of Mass Spectrometry based Biophysical Approaches

Development and Application of Mass Spectrometry based Biophysical Approaches
  • Author : Ying Zhang
  • Publisher : Unknown
  • Release Date : 2015
  • Total pages : 492
  • ISBN : 0471705160
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Summary : Mass spectrometry (MS)-based biophysical approaches are new "tools" for protein characterization owing to its capability to analyze proteins and protein complexes that range in molecular weight from kDa to MDa. Protein characterization requires more than identifying the primary structure. More importantly, protein high order structures (i.e., secondary, tertiary ...

Biophysical Characterization of Proteins in Developing Biopharmaceuticals

Biophysical Characterization of Proteins in Developing Biopharmaceuticals
  • Author : Damian J. Houde,Steven A. Berkowitz
  • Publisher : Elsevier
  • Release Date : 2019-11-13
  • Total pages : 586
  • ISBN : 0471705160
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Summary : Biophysical Characterization of Proteins in Developing Biopharmaceuticals, Second Edition, presents the latest on the analysis and characterization of the higher-order structure (HOS) or conformation of protein based drugs. Starting from the very basics of protein structure, this book explains the best way to achieve this goal using key methods commonly ...

Methods in Modern Biophysics

Methods in Modern Biophysics
  • Author : Bengt Nölting
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-03-09
  • Total pages : 254
  • ISBN : 0471705160
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Summary : Incorporating dramatic recent advances, "Methods in Modern Biophysics" presents a fresh and timely introduction to modern biophysical methods. This innovative text surveys and explains the ten key biophysical methods, including those related to biophysical nanotechnology, scanning probe microscopy, X-ray crystallography, ion mobility spectrometry, mass spectrometry, and proteomics. Containing much information ...

Biophysical Applications of Amide Protein Hydrogen Exchange and MALDI Mass Spectrometry to Protein Folding

Biophysical Applications of Amide Protein Hydrogen Exchange and MALDI Mass Spectrometry to Protein Folding
  • Author : Yuan Dai
  • Publisher : Unknown
  • Release Date : 2006
  • Total pages : 268
  • ISBN : 0471705160
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Summary : Download or read online Biophysical Applications of Amide Protein Hydrogen Exchange and MALDI Mass Spectrometry to Protein Folding written by Yuan Dai, published by which was released on 2006. Get Biophysical Applications of Amide Protein Hydrogen Exchange and MALDI Mass Spectrometry to Protein Folding Books now! Available in PDF, ePub and ...

Mass spectrometry in chemical physics biophysics and environmental sciences

Mass spectrometry in chemical physics  biophysics and environmental sciences
  • Author : Международный Семинар-Школа Масс-Спектрометрия в Химической Физике, Биофизике и Экологии
  • Publisher : Unknown
  • Release Date : 2004
  • Total pages : 284
  • ISBN : 0471705160
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Summary : Download or read online Mass spectrometry in chemical physics biophysics and environmental sciences written by Международный Семинар-Школа Масс-Спектрометрия в Химической Физике, Биофизике и Экологии, published by which was released on 2004. Get Mass spectrometry in chemical physics biophysics and environmental sciences Books now! Available in PDF, ePub and Kindle....

Hydrogen Exchange Mass Spectrometry of Proteins

Hydrogen Exchange Mass Spectrometry of Proteins
  • Author : David D. Weis
  • Publisher : John Wiley & Sons
  • Release Date : 2016-03-21
  • Total pages : 376
  • ISBN : 0471705160
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Summary : Hydrogen exchange mass spectrometry is widely recognized for its ability to probe the structure and dynamics of proteins. The application of this technique is becoming widespread due to its versatility for providing structural information about challenging biological macromolecules such as antibodies, flexible proteins and glycoproteins. Although the technique has been ...

Biophysical Mass Spectrometry Techniques for Probing the Higher Order Structure of Proteins and Complexes

Biophysical Mass Spectrometry Techniques for Probing the Higher Order Structure of Proteins and Complexes
  • Author : Sterling, Jr. (Harry John)
  • Publisher : Unknown
  • Release Date : 2012
  • Total pages : 366
  • ISBN : 0471705160
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Summary : Electrospray ionization mass spectrometry (ESI-MS) is a powerful analytical platform for answering a wide variety of questions about the identity, quantity, structure, function, dynamics and energetics of biological molecules. Key advantages of ESI-MS include unrivaled specificity, attomole sensitivity, and the capacity for simultaneous analysis of complex mixtures with analyte masses ...

Molecular Biophysics for the Life Sciences

Molecular Biophysics for the Life Sciences
  • Author : Norma Allewell,Linda O. Narhi,Ivan Rayment
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-09-28
  • Total pages : 397
  • ISBN : 0471705160
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Summary : This volume provides an overview of the development and scope of molecular biophysics and in-depth discussions of the major experimental methods that enable biological macromolecules to be studied at atomic resolution. It also reviews the physical chemical concepts that are needed to interpret the experimental results and to understand how ...

Novel Mass Spectrometry based Strategies for Biophysical Analysis of Proteins and Protein ligand Complexes

Novel Mass Spectrometry based Strategies for Biophysical Analysis of Proteins and Protein ligand Complexes
  • Author : Liangjie Tang
  • Publisher : ProQuest
  • Release Date : 2007
  • Total pages : 308
  • ISBN : 0471705160
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Summary : The third protocol developed here is a SUPREX-like protocol that employs a chemical modification reaction (i.e., oxidation reaction) in place of the amide H/D exchange reaction in SUPREX. This SUPREX-like protocol, termed SPROX (Stability of Proteins from Rates of Oxidation) was developed and tested to detect and quantify ...

Biophysical Chemistry

Biophysical Chemistry
  • Author : Alan Cooper
  • Publisher : Royal Society of Chemistry
  • Release Date : 2015-11-09
  • Total pages : 212
  • ISBN : 0471705160
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Summary : Biophysical Chemistry covers the physical chemistry of biological macromolecules and the experimental techniques used to study them. Topics covered include: an introduction to biological molecules; spectroscopy, mass spectrometry and hydrodynamics of macromolecules; a ""bluffer's guide"" to molecular thermodynamics; biomolecular kinetics; chromatography and electrophoresis; and single-molecule methods. The easily digestible, pragmatic ...

Biophysical Methods for Biotherapeutics

Biophysical Methods for Biotherapeutics
  • Author : Tapan K. Das
  • Publisher : Wiley
  • Release Date : 2014-04-28
  • Total pages : 376
  • ISBN : 0471705160
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Summary : With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development. • Helps formulation and analytical scientists in pharma and biotech better understand and use biophysical methods • Chapters organized according to the sequential nature of the drug development process • Helps formulation, analytical, ...

Biophysical Chemistry of Proteins

Biophysical Chemistry of Proteins
  • Author : Engelbert Buxbaum
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-11-18
  • Total pages : 510
  • ISBN : 0471705160
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Summary : The book is structured in nine sections, each containing several chapters. The volume starts with an overview of analytical techniques and progresses through purification of proteins; protein modification and inactivation; protein size, shape, and structure; enzyme kinetics; protein-ligand interactions; industrial enzymology; and laboratory quality control. The book is targeted at ...

Introduction to Biomolecular Structure and Biophysics

Introduction to Biomolecular Structure and Biophysics
  • Author : Gauri Misra
  • Publisher : Springer
  • Release Date : 2017-09-07
  • Total pages : 274
  • ISBN : 0471705160
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Summary : This comprehensive book presents a modern concept in biophysics based on recently published research. It highlights various aspects of the biophysical fundamentals and techniques that are currently used to study different physical properties of biomolecules, and relates the biological phenomenon with the underlying physical concepts. The content is divided into ...