Biophysical Characterization of Proteins in Developing Biopharmaceuticals

Written By Damian J. Houde
Biophysical Characterization of Proteins in Developing Biopharmaceuticals
  • Publsiher : Elsevier
  • Release : 13 November 2019
  • ISBN : 0444641742
  • Pages : 586 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Biophysical Characterization of Proteins in Developing Biopharmaceuticals written by Damian J. Houde which was release on 13 November 2019, this book published by Elsevier. Available in PDF, EPUB and Kindle Format. Book excerpt: Biophysical Characterization of Proteins in Developing Biopharmaceuticals, Second Edition, presents the latest on the analysis and characterization of the higher-order structure (HOS) or conformation of protein based drugs. Starting from the very basics of protein structure, this book explains the best way to achieve this goal using key methods commonly employed in the biopharmaceutical industry. This book will help today’s industrial scientists plan a career in this industry and successfully implement these biophysical methodologies. This updated edition has been fully revised, with new chapters focusing on the use of chromatography and electrophoresis and the biophysical characterization of very large biopharmaceuticals. In addition, best practices of applying statistical analysis to biophysical characterization data is included, along with practical issues associated with the concept of a biopharmaceutical’s developability and the technical decision-making process needed when dealing with biophysical characterization data. Presents basic protein characterization methods and tools applicable to (bio)pharmaceutical research and development Highlights the capabilities and limitations of each technique Discusses the underlining science of each tool Empowers industrial biophysical chemists by providing a roadmap for applying biophysical tools Outlines the needs for new characterization and analytical tools in the biopharmaceutical industry

Biophysical Characterization of Proteins in Developing Biopharmaceuticals

Biophysical Characterization of Proteins in Developing Biopharmaceuticals
  • Author : Damian J. Houde,Steven A. Berkowitz
  • Publisher : Elsevier
  • Release Date : 2019-11-13
  • Total pages : 586
  • ISBN : 0444641742
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Summary : Biophysical Characterization of Proteins in Developing Biopharmaceuticals, Second Edition, presents the latest on the analysis and characterization of the higher-order structure (HOS) or conformation of protein based drugs. Starting from the very basics of protein structure, this book explains the best way to achieve this goal using key methods commonly ...

Biosimilar Drug Product Development

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  • Author : Laszlo Endrenyi,Dr. Paul Declerck,Shein-Chung Chow
  • Publisher : CRC Press
  • Release Date : 2017-02-24
  • Total pages : 477
  • ISBN : 0444641742
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Summary : When a biological drug patent expires, alternative biosimilar products are developed. The development of biosimilar products is complicated and involves numerous considerations and steps. The assessment of biosimilarity and interchangeability is also complicated and difficult. Biosimilar Drug Product Development presents current issues for the development of biosimilars and gives detailed ...

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  • Author : David D. Weis
  • Publisher : John Wiley & Sons
  • Release Date : 2016-01-12
  • Total pages : 376
  • ISBN : 0444641742
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Summary : Hydrogen exchange mass spectrometry is widely recognized for its ability to probe the structure and dynamics of proteins. The application of this technique is becoming widespread due to its versatility for providing structural information about challenging biological macromolecules such as antibodies, flexible proteins and glycoproteins. Although the technique has been ...

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  • Publisher : Royal Society of Chemistry
  • Release Date : 2019-08-16
  • Total pages : 543
  • ISBN : 0444641742
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Summary : Peptide therapy has become a key strategy in innovative drug development, however, one of the potential barriers for the development of novel peptide drugs in the clinic is their deficiencies in clearly defined chemistry, manufacturing and controls (CMC) strategy from clinical development to commercialization. CMC can often become a rate-limiting ...

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Biophysics for Therapeutic Protein Development
  • Author : Linda O. Narhi
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-02-26
  • Total pages : 293
  • ISBN : 0444641742
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Summary : This book can be used to provide insight into this important application of biophysics for those who are planning a career in protein therapeutic development, and for those outside this area who are interested in understanding it better. The initial chapters describe the underlying theory, and strengths and weaknesses of ...

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  • Publisher : Springer Nature
  • Release Date : 2020-03-13
  • Total pages : 893
  • ISBN : 0444641742
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Summary : The biotechnology/biopharmaceutical sector has tremendously grown which led to the invention of engineered antibodies such as Antibody Drug Conjugates (ADCs), Bispecific T-cell engager (BITES), Dual Variable Domain (DVD) antibodies, and fusion proteins that are currently being used as therapeutic agents for immunology, oncology and other disease conditions. Regulatory agencies ...

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  • Author : Tapan K. Das
  • Publisher : Wiley
  • Release Date : 2014-04-28
  • Total pages : 376
  • ISBN : 0444641742
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Summary : With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development. • Helps formulation and analytical scientists in pharma and biotech better understand and use biophysical methods • Chapters organized according to the sequential nature of the drug development process • Helps formulation, analytical, ...

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  • Publisher : Springer
  • Release Date : 2016-05-13
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  • ISBN : 0444641742
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Summary : This book introduces analytical ultracentrifugation (AUC) as a whole, covering essential theoretical and practical aspects as well as its applications in both biological and non-biological systems. Comprehensive characterizations of macromolecules in a solution are now routinely required not only for understanding the solution system but also for producing a solution ...

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  • Publisher : Cambridge University Press
  • Release Date : 2018-10-31
  • Total pages : 212
  • ISBN : 0444641742
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Summary : This innovative reference provides a coherent and critical view on the potential benefits of a transition from batch to continuous processes in the biopharmaceutical industry, with the main focus on chromatography. It also covers the key topics of protein stability and protein conjugation, addressing the chemical reaction and purification aspects ...

Biophysical Methods for Biotherapeutics

Biophysical Methods for Biotherapeutics
  • Author : Tapan K. Das
  • Publisher : John Wiley & Sons
  • Release Date : 2014-02-27
  • Total pages : 376
  • ISBN : 0444641742
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Summary : With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development. • Helps formulation and analytical scientists in pharma and biotech better understand and use biophysical methods • Chapters organized according to the sequential nature of the drug development process • Helps formulation, analytical, ...

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  • Publisher : John Wiley & Sons
  • Release Date : 2010-07-13
  • Total pages : 976
  • ISBN : 0444641742
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Summary : A real-world guide to the production and manufacturing of biopharmaceuticals While much has been written about the science of biopharmaceuticals, there is a need for practical, up-to-date information on key issues at all stages of developing and manufacturing commercially viable biopharmaceutical drug products. This book helps fill the gap in ...

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  • Publisher : Springer
  • Release Date : 2019-04-13
  • Total pages : 653
  • ISBN : 0444641742
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Summary : This introductory text explains both the basic science and the applications of biotechnology-derived pharmaceuticals, with special emphasis on their clinical use. It serves as a complete one-stop source for undergraduate/graduate pharmacists, pharmaceutical science students, and for those in the pharmaceutical industry. The Fifth Edition completely updates the previous edition, ...

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  • Publisher : Springer
  • Release Date : 2018-07-22
  • Total pages : 599
  • ISBN : 0444641742
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Summary : In this volume, the authors discuss the many significant challenges currently faced in biotechnology dosage form development, providing guidance, shared experience and thoughtful reflection on how best to address these potential concerns. As the field of therapeutic recombinant therapeutic proteins enters its fourth decade and the market for biopharmaceuticals becomes ...

Industrial Biotechnology

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  • Author : United States,United States. Congress. House. Committee on Science. Subcommittee on Technology
  • Publisher : Unknown
  • Release Date : 1998
  • Total pages : 50
  • ISBN : 0444641742
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Summary : Download or read online Industrial Biotechnology written by United States,United States. Congress. House. Committee on Science. Subcommittee on Technology, published by which was released on 1998. Get Industrial Biotechnology Books now! Available in PDF, ePub and Kindle....

Structural Biology in Drug Discovery

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  • Author : Jean-Paul Renaud
  • Publisher : John Wiley & Sons
  • Release Date : 2020-01-09
  • Total pages : 688
  • ISBN : 0444641742
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Summary : With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and ...