Biological DNA Sensor

Written By Ken J. Ishii
Biological DNA Sensor
  • Publsiher : Academic Press
  • Release : 07 November 2013
  • ISBN : 9780124047327
  • Pages : 352 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Biological DNA Sensor written by Ken J. Ishii which was release on 07 November 2013, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics. Multi-authored by a distinguished panel of world-class experts Ideal source of information for those wanting to learn about DNA sensing Provides in-depth explanations of DNA sensing pathways and the innate immune system, bridging the gap between them

Biological DNA Sensor

Biological DNA Sensor
  • Author : Ken J. Ishii,Choon Kit Tang
  • Publisher : Academic Press
  • Release Date : 2013-11-07
  • Total pages : 352
  • ISBN : 9780124047327
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Summary : Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its ...

Biological DNA Sensor

Biological DNA Sensor
  • Author : Choon Kit Tang,Cevayir Coban,Shizuo Akira,Ken J. Ishii
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-10-30
  • Total pages : 368
  • ISBN : 9780124047327
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Summary : In this chapter, we reflect on our early understanding of the immunogenic properties of dsDNA and give a chronological account of the journey we have taken to discover the individual cellular DNA sensors which have played important roles in mediating DNA induced inflammation....

Biological DNA Sensor

Biological DNA Sensor
  • Author : Y.J. Shen,A.R. Lam,S.W.S. Ho,C.X. Koo,N. Le Bert,S. Gasser
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-10-30
  • Total pages : 368
  • ISBN : 9780124047327
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Summary : Toll-like receptors, NOD-like receptors and numerous intracellular sensors that detect nucleotides in the cytosol help to initiate immune responses to viral infections. Many of the cytosolic nucleotide sensors and their downstream mediators also play a role in RNA metabolism, DNA repair and cancer. Here we review the evidence that links ...

Biological DNA Sensor

Biological DNA Sensor
  • Author : Christophe J. Desmet
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-10-30
  • Total pages : 368
  • ISBN : 9780124047327
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Summary : Aluminum-based adjuvants (alum) are among the oldest and most widely used vaccine adjuvants. After decades of largely empirical use, the last years have witnessed a flurry of studies aiming to decipher the immunological mechanisms of action of alum. Along with other hypotheses, recent reports support that alum induces the release ...

Biological DNA Sensor

Biological DNA Sensor
  • Author : Surya Pandey,Taro Kawai
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-10-30
  • Total pages : 368
  • ISBN : 9780124047327
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Summary : DNA sensors initiate innate immune responses upon recognition of microbial and self-derived DNA in the intracellular compartments or cytoplasm. These sensors include TLR9, AIM2 like receptors and many other recently identified cytosolic DNA sensors. The otherwise protective nature of host defense by these receptors can turn hostile when they recognize ...

Biological DNA Sensor

Biological DNA Sensor
  • Author : Søren R. Paludan,Andrew G. Bowie
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-10-30
  • Total pages : 368
  • ISBN : 9780124047327
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Summary : Microbial and host DNA are potent stimulators of innate immune responses and have been implicated in both host defense and autoimmune diseases. To date more than 10 immunological sensors of DNA have been proposed, and we are now beginning to understand the functions and mechanism of action of these proposed DNA ...

Biological DNA Sensor

Biological DNA Sensor
  • Author : Glen N. Barber
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-10-30
  • Total pages : 368
  • ISBN : 9780124047327
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Summary : Invading microbes are detected by cellular sensors, the consequences of which result in the production of potent anti-pathogen proteins such as type I interferon (IFN) as well as other cytokines capable of stimulating the adaptive immune response. Examples comprise the RIG-I-like helicase (RLH) and the Toll-like receptor (TLR) families which ...

Biological DNA Sensor

Biological DNA Sensor
  • Author : Jan Naujoks,Bastian Opitz
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-10-30
  • Total pages : 368
  • ISBN : 9780124047327
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Summary : The detection of bacterial pathogens by the innate immune system is mediated by various pattern recognition receptors that sense microbial molecules such as cell wall components, virulence factors or nucleic acids. Bacterial DNA is recognized by Toll-like receptor 9 (TLR9) at endosomal compartments and by cyclic GMP-AMP synthase, polymerase III/RIG-I, ...

Biological DNA Sensor

Biological DNA Sensor
  • Author : Rebecca Schmidt,Laurel L. Lenz
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-10-30
  • Total pages : 368
  • ISBN : 9780124047327
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Summary : Cyclic dinucleotides (c-di-NMPs), such as c-di-GMP and c-di-AMP were first discovered in bacteria, where they play important roles as second messenger molecules that regulate bacterial cellular functions. In addition, these and other c-di-NMPs exert potent biological effects on mammalian cells, such as the inhibition of cancer cell proliferation, immune cell ...

Biological DNA Sensor

Biological DNA Sensor
  • Author : Sivapriya Kailasan Vanaja,Vijay A.K. Rathinam,Katherine A. Fitzgerald
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-10-30
  • Total pages : 368
  • ISBN : 9780124047327
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Summary : The innate immune response serves as the first line of defense against microbial infections by detecting pathogen-associated molecular patterns through germline-encoded pattern recognition receptors. Proteins of the PYHIN family have gained substantial research focus in recent years as central mediators of innate immune responses induced by cytosolic microbial DNA. Sensing ...

Biological DNA Sensor

Biological DNA Sensor
  • Author : Cevayir Coban,Miyuki Tozuka,Nao Jounai,Kouji Kobiyama,Fumihiko Takeshita,Choon Kit Tang,Ken J. Ishii
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-10-30
  • Total pages : 368
  • ISBN : 9780124047327
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Summary : Ideal vaccines are expected to give lifetime protection from infectious diseases, and if possible, from allergic diseases, autoimmune diseases and cancer. DNA vaccination was introduced two decades ago as a simple plasmid inoculation method with a capability of inducing both cellular and humoral immune responses. Recent studies have provided insights ...

Biological DNA Sensor

Biological DNA Sensor
  • Author : Tatsuya Saitoh
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-10-30
  • Total pages : 368
  • ISBN : 9780124047327
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Summary : Microbial double-stranded (ds)DNA potently stimulates innate immunity. Stimulator of interferon genes (STING) plays a major role in dsDNA-induced expression of type I interferons (IFNs) and elimination of invading pathogens. After stimulation, STING translocates from the endoplasmic reticulum to cytoplasmic punctate structures where it associates with TANK-binding kinase 1 (TBK1). TBK1 ...

Biological DNA Sensor

Biological DNA Sensor
  • Author : Kenichi Shimada,Timothy R. Crother,Moshe Arditi
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-10-30
  • Total pages : 368
  • ISBN : 9780124047327
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Summary : DNA damage exists in all cellular organisms. While DNA damage is distinguished from mutation, mutation can result from unrepaired DNA. While most DNA damage can be repaired, such repair systems are not 100% efficient. Un-repaired DNA damage accumulates in non-replicating cells, such as neurons or myocytes of adult mammals, and can ...

Biological DNA Sensor

Biological DNA Sensor
  • Author : Ann Marshak-Rothstein,Michael P. Cancro
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-10-30
  • Total pages : 368
  • ISBN : 9780124047327
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Summary : In vitro analyses of autoreactive B cells and pDCs clearly demonstrate a critical role for both TLR7 and TLR9 in the detection of endogenous nucleic acid ligands and activation of autoreactive B cells and dendritic cell subsets. Ligands for TLR7 and TLR9 are bound by surface receptors, either the BCR ...

Biological DNA Sensor

Biological DNA Sensor
  • Author : Ken Ishii,Choon Kit Tang
  • Publisher : Academic Press
  • Release Date : 2013-10-30
  • Total pages : 368
  • ISBN : 9780124047327
GET BOOK

Summary : Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its ...