Biased Signaling in Physiology Pharmacology and Therapeutics

Written By Brian J. Arey
Biased Signaling in Physiology  Pharmacology and Therapeutics
  • Publsiher : Academic Press
  • Release : 17 June 2014
  • ISBN : 9780124114609
  • Pages : 316 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Biased Signaling in Physiology Pharmacology and Therapeutics written by Brian J. Arey which was release on 17 June 2014, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective. Offers a unique and valuable resource on biased receptor signaling that provides a global view for better understanding pharmacology across many receptor families Integrates biased receptor signaling, physiology, and pharmacology to place this emerging science within the context of treating disease Includes important chapters on both the pharmaceutical and therapeutic implications of biased signaling

Biased Signaling in Physiology Pharmacology and Therapeutics

Biased Signaling in Physiology  Pharmacology and Therapeutics
  • Author : Brian J. Arey
  • Publisher : Academic Press
  • Release Date : 2014-06-17
  • Total pages : 316
  • ISBN : 9780124114609
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Summary : Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors ...

Biased Signaling in Physiology Pharmacology and Therapeutics

Biased Signaling in Physiology  Pharmacology and Therapeutics
  • Author : Brian J Arey
  • Publisher : Academic Press
  • Release Date : 2018-11-13
  • Total pages : 316
  • ISBN : 9780124114609
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Summary : Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors ...

Biased Signaling in Physiology Pharmacology and Therapeutics

Biased Signaling in Physiology  Pharmacology and Therapeutics
  • Author : Brian J Arey
  • Publisher : Elsevier
  • Release Date : 2014-06-05
  • Total pages : 316
  • ISBN : 9780124114609
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Summary : Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-dependent activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors ...

Pharmacology and Therapeutics of Constitutively Active Receptors

Pharmacology and Therapeutics of Constitutively Active Receptors
  • Author : Ya-Xiong Tao
  • Publisher : Elsevier
  • Release Date : 2014-06-11
  • Total pages : 440
  • ISBN : 9780124114609
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Summary : Volume 70 of Advances in Pharmacology presents the pharmacology and therapeutics of constitutively active receptors. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists, and biochemists alike. Advances in Pharmacology provides a rich collection of reviews on timely topics. ...

GPCRs

GPCRs
  • Author : Beata Jastrzebska,Paul S.-H. Park
  • Publisher : Academic Press
  • Release Date : 2019-09-11
  • Total pages : 500
  • ISBN : 9780124114609
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Summary : GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric ...

Pharmacology of G Protein Coupled Receptors

Pharmacology of G Protein Coupled Receptors
  • Author : S. J. Enna
  • Publisher : Academic Press
  • Release Date : 2011
  • Total pages : 391
  • ISBN : 9780124114609
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Summary : G protein coupled receptors remain the most important class of therapeutic targets in medicine. In the last 5 years, tremendous advances have been made in our understanding of the structure and mechanism of this critical family of drug targets. The present volume explores the modern experimental and conceptual framework for drug ...

GPCRs

GPCRs
  • Author : Beata Jastrzebska,Paul S. H. Park
  • Publisher : Academic Press
  • Release Date : 2019-10
  • Total pages : 552
  • ISBN : 9780124114609
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Summary : GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric ...

Arrestins Pharmacology and Therapeutic Potential

Arrestins   Pharmacology and Therapeutic Potential
  • Author : Vsevolod V. Gurevich
  • Publisher : Springer Science & Business Media
  • Release Date : 2013-11-29
  • Total pages : 447
  • ISBN : 9780124114609
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Summary : This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting ...

G Protein Coupled Receptors

G Protein Coupled Receptors
  • Author : Anonim
  • Publisher : Academic Press
  • Release Date : 2013-01-17
  • Total pages : 440
  • ISBN : 9780124114609
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Summary : This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, ...

Pharmacology in Drug Discovery and Development

Pharmacology in Drug Discovery and Development
  • Author : Terry Kenakin
  • Publisher : Academic Press
  • Release Date : 2016-10-21
  • Total pages : 350
  • ISBN : 9780124114609
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Summary : Pharmacology in Drug Discovery and Development: Understanding Drug Response, Second Edition, is an introductory resource illustrating how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. The concepts discussed in this book ...

Pharmacology

Pharmacology
  • Author : H. P. Rang
  • Publisher : Unknown
  • Release Date : 2001
  • Total pages : 839
  • ISBN : 9780124114609
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Summary : Adapted for the U.S., this New Edition of PHARMACOLOGY, a popular UK text, describes what drugs do and emphasizes the mechanisms by which they act. The U.S. edition is revised and updated to reflect the substantial differences in drug names, FDA approvals, terminology, and guidelines for use. It ...

Dissertation Abstracts International

Dissertation Abstracts International
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1999
  • Total pages : 212
  • ISBN : 9780124114609
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Summary : Download or read online Dissertation Abstracts International written by , published by which was released on 1999. Get Dissertation Abstracts International Books now! Available in PDF, ePub and Kindle....

American Book Publishing Record

American Book Publishing Record
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2003
  • Total pages : 212
  • ISBN : 9780124114609
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Summary : Download or read online American Book Publishing Record written by , published by which was released on 2003. Get American Book Publishing Record Books now! Available in PDF, ePub and Kindle....

Psychopharmacology Abstracts

Psychopharmacology Abstracts
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1981
  • Total pages : 212
  • ISBN : 9780124114609
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Summary : Download or read online Psychopharmacology Abstracts written by , published by which was released on 1981. Get Psychopharmacology Abstracts Books now! Available in PDF, ePub and Kindle....

Basic Clinical Pharmacology Thirteenth Edition SMARTBOOKTM

Basic   Clinical Pharmacology  Thirteenth Edition  SMARTBOOKTM
  • Author : Bertram G. Katzung,Anthony J. Trevor
  • Publisher : McGraw Hill Professional
  • Release Date : 2014-12-22
  • Total pages : 1216
  • ISBN : 9780124114609
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Summary : Gain a full understanding of the basic science andclinical use of drugs with the most up-to-date andcomprehensive pharmacology text in the health sciences A Doody's Core Title for 2017! 400 ILLUSTRATIONS--MANY IN FULL COLOR Organized to reflect the course sequence in many pharmacology courses and in integrated curricula, Basic & Clinical Pharmacology covers ...