Basics of Chimeric Antigen Receptor CAR Immunotherapy

Written By Mumtaz Y. Balkhi
Basics of Chimeric Antigen Receptor  CAR  Immunotherapy
  • Publsiher : Academic Press
  • Release : 31 July 2019
  • ISBN : 0128197471
  • Pages : 92 pages
  • Rating : 4/5 from 21 reviews
GET THIS BOOKBasics of Chimeric Antigen Receptor CAR Immunotherapy


Read or download book entitled Basics of Chimeric Antigen Receptor CAR Immunotherapy written by Mumtaz Y. Balkhi which was release on 31 July 2019, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: Basics of Chimeric Antigen Receptor (CAR) Immunotherapy presents the latest on how T cell adoptive immunotherapy has progressed in its ultimate goal of curing metastatic malignant cancers. Recent clinical data obtained with checkpoint receptor blockade inhibitors and chimeric antigen receptor (CAR) therapy has been especially promising, thus generating renewed hope that we may be on the verge of finally curing cancer. Over the years, huge progress has been made in controlling several stage IV metastasized cancers through the clinical application of checkpoint receptor inhibitory drugs and CAR-Therapy that has seen unprecedented interest in the immunotherapy field. Presents the first book to provide a basic understanding of chimeric antigen receptor (CARs) design, production and clinical application protocols Provides unique authority as the editor has worked directly with CARs Discusses the challenges encountered in actual clinical trials and how these challenges can be overcome Includes a full chapter on various challenges researchers should expect to encounter in the CAR-therapy field

Basics of Chimeric Antigen Receptor CAR Immunotherapy

Basics of Chimeric Antigen Receptor  CAR  Immunotherapy
  • Author : Mumtaz Y. Balkhi
  • Publisher : Academic Press
  • Release Date : 2019-07-31
  • Total pages : 92
  • ISBN : 0128197471
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Summary : Basics of Chimeric Antigen Receptor (CAR) Immunotherapy presents the latest on how T cell adoptive immunotherapy has progressed in its ultimate goal of curing metastatic malignant cancers. Recent clinical data obtained with checkpoint receptor blockade inhibitors and chimeric antigen receptor (CAR) therapy has been especially promising, thus generating renewed hope ...

Part I Understanding Cancer Immunotherapy A brief Review Part II What is Chimeric Antigen Receptor CAR T Cell Therapy An Emerging Cancer Treatment Modality

Part I  Understanding Cancer Immunotherapy  A brief Review  Part II      What is Chimeric Antigen Receptor  CAR T Cell Therapy  An Emerging Cancer Treatment Modality
  • Author : Dr. Hakim Saboowala
  • Publisher : Dr.Hakim Saboowala
  • Release Date : 2020-05-04
  • Total pages : 212
  • ISBN : 0128197471
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Summary : Part I- Understanding Cancer Immunotherapy: A brief Review. Immunotherapy, also called biologic therapy, is a type of cancer treatment that boosts the body's natural defenses to fight cancer. It uses substances made by the body or in a laboratory to improve or restore immune system function. Immunotherapy may work by: ...

Chimeric Antigen Receptor CAR T cell Immunotherapy for MUC1 positive Breast Cancer

Chimeric Antigen Receptor  CAR  T cell Immunotherapy for MUC1 positive Breast Cancer
  • Author : Artemis Gavriil
  • Publisher : Unknown
  • Release Date : 2018
  • Total pages : 212
  • ISBN : 0128197471
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Summary : Download or read online Chimeric Antigen Receptor CAR T cell Immunotherapy for MUC1 positive Breast Cancer written by Artemis Gavriil, published by which was released on 2018. Get Chimeric Antigen Receptor CAR T cell Immunotherapy for MUC1 positive Breast Cancer Books now! Available in PDF, ePub and Kindle....

Defining Optimal T Cell Characteristics for Pediatric Chimeric Antigen Receptor CAR T Cell Trials

Defining Optimal T Cell Characteristics for Pediatric Chimeric Antigen Receptor  CAR  T Cell Trials
  • Author : Julie M. Rivers
  • Publisher : Unknown
  • Release Date : 2017
  • Total pages : 23
  • ISBN : 0128197471
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Summary : Background: Engineered chimeric antigen receptor (CAR) T cells have emerged as a powerful, highly personalized immunotherapy in pediatric cancer. Early phase clinical trials using CAR T cells targeting CD19 have resulted in complete response (CR) rates as high as 93% in children with relapsed and refractory acute lymphoblastic leukemia (ALL). Despite ...

Immunotherapy Using Chimeric Antigen Receptor Macrophage

Immunotherapy Using Chimeric Antigen Receptor Macrophage
  • Author : Peng Fei Huang
  • Publisher : Unknown
  • Release Date : 2019
  • Total pages : 44
  • ISBN : 0128197471
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Summary : Chimeric antigen receptor (CAR) T cell immunotherapy has become one of the most prominent and leading cancer therapies due to its remarkable success in targeting hematological malignancies. Unfortunately, CAR-T cell immunotherapy has not had the same amount of success in solid tumors due to the challenging tumor's immunosuppressive microenvironment. Therefore, ...

Immunotherapy of Solid Tumors Multimodal Imaging Strategies for Chimeric Antigen Receptor T Cell Tracking in the Tumor Microenvironment

Immunotherapy of Solid Tumors  Multimodal Imaging Strategies for Chimeric Antigen Receptor T Cell Tracking in the Tumor Microenvironment
  • Author : Janina Henze
  • Publisher : Unknown
  • Release Date : 2021
  • Total pages : 212
  • ISBN : 0128197471
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Summary : Immunotherapy is an emerging building block of modern oncology, after chimeric antigen receptor (CAR) T cells demonstrated groundbreaking survival rates in hematological malignancies. However, therapy success in more common solid tumors has not been achieved yet, due to a variety of obstacles, such as a limited availability of suitable targets ...

Fast Facts CAR T Cell Therapy

Fast Facts  CAR T Cell Therapy
  • Author : R.J. Buka,A.J. Kansagra
  • Publisher : Karger Medical and Scientific Publishers
  • Release Date : 2021-01-26
  • Total pages : 72
  • ISBN : 0128197471
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Summary : Chimeric antigen receptor (CAR) T cells are genetically engineered immune cells that can seek out and destroy cancer cells. The results from their use in cancer immunotherapy have been very promising, but treatment is often associated with frequent, serious short-term toxicities. 'Fast Facts: CAR-T Therapy' explains what CAR T cells ...

Chimeric Antigen Receptor T Cell Therapies for Cancer E Book

Chimeric Antigen Receptor T Cell Therapies for Cancer E Book
  • Author : Daniel W. Lee,Nirali N. Shah
  • Publisher : Elsevier Health Sciences
  • Release Date : 2019-11-30
  • Total pages : 244
  • ISBN : 0128197471
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Summary : From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali ...

CAR T Cell Therapies for Non Hematopoietic Malignancies Taking Off The Training Wheels

CAR T Cell Therapies for Non Hematopoietic Malignancies  Taking Off The Training Wheels
  • Author : Avery Dexter Posey, Jr.,John - Maher,Marcela V. Maus
  • Publisher : Frontiers Media SA
  • Release Date : 2020-04-24
  • Total pages : 212
  • ISBN : 0128197471
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Summary : Chimeric antigen receptor (CAR) T cell therapies for leukemia (e.g. tisagenlecleucel) and lymphoma (e.g. axicabtagene ciloleucel) have recently received regulatory approval in the United States. Phase I/II trials have demonstrated complete remission of refractory or relapsed tumors in 50% - 94% patients. However, the clinical successes of engineered T ...

Fast Facts CAR T Cell Therapy

Fast Facts  CAR T Cell Therapy
  • Author : Richard J. Buka,Ankit J. Kansagra
  • Publisher : Karger Medical and Scientific Publishers
  • Release Date : 2021-02-28
  • Total pages : 72
  • ISBN : 0128197471
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Summary : Chimeric antigen receptor (CAR) T cells are genetically engineered immune cells that can seek out and destroy cancer cells. The results from their use in cancer immunotherapy have been very promising, but treatment is often associated with frequent, serious short-term toxicities. 'Fast Facts: CAR-T Therapy' explains what CAR T cells ...

The Regulatory Landscape of CAR T Cell Dysfunction

The Regulatory Landscape of CAR T Cell Dysfunction
  • Author : David George Gennert
  • Publisher : Unknown
  • Release Date : 2021
  • Total pages : 212
  • ISBN : 0128197471
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Summary : Chimeric Antigen Receptor (CAR) T cells have emerged as a promising immunotherapy strategy to target cancer in a subset of patients. T cell exhaustion presents a significant barrier to the progress of CAR T cell therapy development and efficacy. We use a human CAR T cell model system, utilizing the ...

Targeting Cancer Stem Cells by T Cell Engineering

Targeting Cancer Stem Cells by T Cell Engineering
  • Author : Nicolas Pierre Desbaillets
  • Publisher : Unknown
  • Release Date : 2017
  • Total pages : 212
  • ISBN : 0128197471
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Summary : Mots-clés de l'auteur: Adoptive T cell therapy ; Breast cancer ; Cancer stem cells (CSCs) ; Chimeric antigen receptor (CAR) ; Dedifferentiation ; Immunotherapy ; Immunotoxin ; Metastases ; Regulatory T cells (Tregs)....

Targeting and Elimination of T Cell Subpopulations by Chimeric Antigen Receptor modified T Cells

Targeting and Elimination of T Cell Subpopulations by Chimeric Antigen Receptor modified T Cells
  • Author : Stela Petkova
  • Publisher : Unknown
  • Release Date : 2021
  • Total pages : 212
  • ISBN : 0128197471
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Summary : Chimeric antigen receptors (CARs) demonstrated a high potential for the elimination of tumor cells in cancer immunotherapy. The first successful application of CAR-expressing T cells aimed at the elimination of B cells in hematological malignancies. However, despite being a breakthrough, which highlighted the potential of the CAR T cell technology, ...

Impact of Immunotherapy in the Treatment of Glioblastoma

Impact of Immunotherapy in the Treatment of Glioblastoma
  • Author : Jessica Silva
  • Publisher : Unknown
  • Release Date : 2018
  • Total pages : 212
  • ISBN : 0128197471
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Summary : Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor. Despite the efforts developed in the respective treatment, consisting of maximal surgical resection followed by adjuvant radiotherapy and chemotherapy, the prognosis remains very poor. This may be partly related to the resistance of GBM cells and their ...

Genome Engineering to Expand Applications of Human T cell Immunotherapy

Genome Engineering to Expand Applications of Human T cell Immunotherapy
  • Author : Alexandra E. Grier
  • Publisher : Unknown
  • Release Date : 2017
  • Total pages : 102
  • ISBN : 0128197471
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Summary : Adoptive T-cell therapy, particularly chimeric antigen receptor (CAR) therapy, is a revolutionary and quickly-evolving means of treating cancer patients who can no longer be helped by standard therapies. In multiple clinical trials, including our own at Seattle Children’s Hospital, CD19 CAR therapy for B-cell leukemia and lymphoma has achieved ...