Astrocytes and Epilepsy

Written By Jacqueline A. Hubbard
Astrocytes and Epilepsy
  • Publsiher : Academic Press
  • Release : 05 July 2016
  • ISBN : 0128026243
  • Pages : 394 pages
  • Rating : 4/5 from 21 reviews
GET THIS BOOKAstrocytes and Epilepsy


Read or download book entitled Astrocytes and Epilepsy written by Jacqueline A. Hubbard which was release on 05 July 2016, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". Much of epilepsy research has focused on neuronal therapeutic targets, but current antiepileptic drugs often cause severe cognitive, developmental, and behavioral side effects. Recent findings indicate a critical contribution of astrocytes, star-shaped glial cells in the brain, to neuronal and network excitability and seizure activity. Furthermore, many important cellular and molecular changes occur in astrocytes in epileptic tissue in both humans and animal models of epilepsy. The goal of Astrocytes and Epilepsy is to comprehensively review exciting findings linking changes in astrocytes to functional changes responsible for epilepsy for the first time in book format. These insights into astrocyte contribution to seizure susceptibility indicate that astrocytes may represent an important new therapeutic target in the control of epilepsy. Astrocytes and Epilepsy includes background explanatory text on astrocyte morphology and physiology, epilepsy models and syndromes, and evidence from both human tissue studies and animal models linking functional changes in astrocytes to epilepsy. Beautifully labelled diagrams are presented and relevant figures from the literature are reproduced to elucidate key findings and concepts in this rapidly emerging field. Astrocytes and Epilepsy is written for neuroscientists, epilepsy researchers, astrocyte investigators as well as neurologists and other specialists caring for patients with epilepsy. Presents the first comprehensive book to synthesize historical and recent research on astrocytes and epilepsy into one coherent volume Provides a great resource on the field of astrocyte biology and astrocyte-neuron interactions Details potential therapeutic targets, including chapters on gap junctions, water and potassium channels, glutamate and adenosine metabolism, and inflammation

Astrocytes and Epilepsy

Astrocytes and Epilepsy
  • Author : Jacqueline A. Hubbard,Devin K. Binder
  • Publisher : Academic Press
  • Release Date : 2016-07-05
  • Total pages : 394
  • ISBN : 0128026243
GET BOOK

Summary : Epilepsy is a devastating group of neurological disorders characterized by periodic and unpredictable seizure activity in the brain. There is a critical need for new drugs and approaches given than at least one-third of all epilepsy patients are not made free of seizures by existing medications and become "medically refractory". ...

Crucial Role for Astrocytes in Epilepsy

Crucial Role for Astrocytes in Epilepsy
  • Author : Peter Bedner,Christian Steinhäuser
  • Publisher : Biota Publishing
  • Release Date : 2015-08-01
  • Total pages : 89
  • ISBN : 0128026243
GET BOOK

Summary : This book summarizes current evidence of astrocyte dysfunction in epilepsy and discusses presumed underlying mechanisms. Epilepsy is characterized by the periodic occurrence of seizures. Currently available anticonvulsant drugs and therapies are insufficient to controlling seizures in about one third of patients. Thus, there is an urgent need for new therapies ...

Departments of Labor Health and Human Services Education and Related Agencies Appropriations for 2007

Departments of Labor  Health and Human Services  Education  and Related Agencies Appropriations for 2007
  • Author : United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
  • Publisher : Unknown
  • Release Date : 2006
  • Total pages : 212
  • ISBN : 0128026243
GET BOOK

Summary : Download or read online Departments of Labor Health and Human Services Education and Related Agencies Appropriations for 2007 written by United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies, published by which was released on 2006. Get Departments of Labor ...

Departments of Labor and Health and Human Services Education and Related Agencies Appropriations

Departments of Labor  and Health and Human Services  Education  and Related Agencies Appropriations
  • Author : United States. Congress. Senate. Committee on Appropriations
  • Publisher : Unknown
  • Release Date : 2007
  • Total pages : 212
  • ISBN : 0128026243
GET BOOK

Summary : Download or read online Departments of Labor and Health and Human Services Education and Related Agencies Appropriations written by United States. Congress. Senate. Committee on Appropriations, published by which was released on 2007. Get Departments of Labor and Health and Human Services Education and Related Agencies Appropriations Books now! Available in ...

Indexes to the Epilepsy Accessions of the Epilepsy Information System

Indexes to the Epilepsy Accessions of the Epilepsy Information System
  • Author : J. Kiffin Penry
  • Publisher : Unknown
  • Release Date : 1978
  • Total pages : 212
  • ISBN : 0128026243
GET BOOK

Summary : Download or read online Indexes to the Epilepsy Accessions of the Epilepsy Information System written by J. Kiffin Penry, published by which was released on 1978. Get Indexes to the Epilepsy Accessions of the Epilepsy Information System Books now! Available in PDF, ePub and Kindle....

Astrocytes

Astrocytes
  • Author : Eliana Scemes,David C. Spray
  • Publisher : CRC Press
  • Release Date : 2016-04-19
  • Total pages : 440
  • ISBN : 0128026243
GET BOOK

Summary : Astrocytes play diverse roles in central nervous system (CNS) function and dysfunction, and the connections that the astrocyte makes with other cells of the brain are essential for a variety of important neural tasks. Bringing together contributions from international experts at the top of their field, Astrocytes: Wiring the Brain ...

The Biochemical Pathology of Astrocytes

The Biochemical Pathology of Astrocytes
  • Author : Michael D. Norenberg,Leif Hertz,Arne Schousboe
  • Publisher : Unknown
  • Release Date : 1988
  • Total pages : 638
  • ISBN : 0128026243
GET BOOK

Summary : Astrocytes have been associated with a number of neuropsychiatric disorders. This edited volume reviews the state of knowledge on the role of astrocytes in such neuropsychiatric conditions as anoxia/ischemia, edema, epilepsy, demyelinative disorders, degenerative diseases, toxic-metabolic encephalopathies, psychiatric abnormalities, and the role of reactive astrocytes in various pathologic states....

Epilepsy

Epilepsy
  • Author : Joan S. Lockard
  • Publisher : Raven Press (ID)
  • Release Date : 1980
  • Total pages : 286
  • ISBN : 0128026243
GET BOOK

Summary : Download or read online Epilepsy written by Joan S. Lockard, published by Raven Press (ID) which was released on 1980. Get Epilepsy Books now! Available in PDF, ePub and Kindle....

Astrocytes in Patho Physiology of the Nervous System

Astrocytes in  Patho Physiology of the Nervous System
  • Author : Vladimir Parpura,Philip G. Haydon
  • Publisher : Springer Science & Business Media
  • Release Date : 2008-12-11
  • Total pages : 738
  • ISBN : 0128026243
GET BOOK

Summary : Astrocytes were the original neuroglia that Ramón y Cajal visualized in 1913 using a gold sublimate stain. This stain targeted intermediate filaments that we now know consist mainly of glial fibrillary acidic protein, a protein used today as an astrocytic marker. Cajal described the morphological diversity of these cells with ...

Archives Internationales de Pharmacodynamie Et de Th rapie

Archives Internationales de Pharmacodynamie Et de Th  rapie
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1977
  • Total pages : 212
  • ISBN : 0128026243
GET BOOK

Summary : Summaries at end of articles....

Indexes to the Epilepsy Accessions of the Epilepsy Information System 40001 50000

Indexes to the Epilepsy Accessions of the Epilepsy Information System  40001 50000
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1982
  • Total pages : 212
  • ISBN : 0128026243
GET BOOK

Summary : "Most of the current scientific literature on the subject, as well as much of the pertinent past literature." Worldwide coverage. Includes monographic and serial literature. Classified arrangement. Each entry gives bibliographical information and classification codes....

Abstract of Volunteer Papers

Abstract of Volunteer Papers
  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 1977
  • Total pages : 887
  • ISBN : 0128026243
GET BOOK

Summary : Download or read online Abstract of Volunteer Papers written by , published by which was released on 1977. Get Abstract of Volunteer Papers Books now! Available in PDF, ePub and Kindle....

Pathological Potential of Neuroglia

Pathological Potential of Neuroglia
  • Author : Vladimir Parpura,Alexei Verkhratsky
  • Publisher : Springer
  • Release Date : 2014-09-26
  • Total pages : 541
  • ISBN : 0128026243
GET BOOK

Summary : Pathophysiological states, neurological and psychiatric diseases are almost universally considered from the neurocentric point of view, with neurons being the principal cellular element of pathological process. The brain homeostasis, which lies at the fulcrum of healthy brain function, the compromise of which invariably results in dysfunction/disease, however, is entirely ...

A Textbook of Epilepsy

A Textbook of Epilepsy
  • Author : John Laidlaw,Alan Richens
  • Publisher : Unknown
  • Release Date : 1982
  • Total pages : 549
  • ISBN : 0128026243
GET BOOK

Summary : Download or read online A Textbook of Epilepsy written by John Laidlaw,Alan Richens, published by which was released on 1982. Get A Textbook of Epilepsy Books now! Available in PDF, ePub and Kindle....

Epilepsy and Cerebral Localization

Epilepsy and Cerebral Localization
  • Author : Wilder Penfield,Theodore Charles Erickson
  • Publisher : Springfield, Ill. : C.C. Thomas
  • Release Date : 1941
  • Total pages : 623
  • ISBN : 0128026243
GET BOOK

Summary : Download or read online Epilepsy and Cerebral Localization written by Wilder Penfield,Theodore Charles Erickson, published by Springfield, Ill. : C.C. Thomas which was released on 1941. Get Epilepsy and Cerebral Localization Books now! Available in PDF, ePub and Kindle....