Antibody Fc

Written By Margaret Ackerman
Antibody Fc
  • Publsiher : Academic Press
  • Release : 06 August 2013
  • ISBN : 0123948185
  • Pages : 358 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Antibody Fc written by Margaret Ackerman which was release on 06 August 2013, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology. Antibodies represent the correlate of protection for numerous vaccines and are the most rapidly growing class of drugs, with applications ranging from cancer and infectious disease to autoimmunity. Researchers have long understood the variable domain of antibodies, which are responsible for antigen recognition, and can provide protection by blocking the function of their target antigen. However, recent developments in our understanding of the protection mediated by antibodies have highlighted the critical nature of the antibody constant, or Fc domain, in the biological activity of antibodies. The Fc domain allows antibodies to link the adaptive and innate immune systems, providing specificity to a wide range of innate effector cells. In addition, they provide a feedback loop to regulate the character of the immune response via interactions with B cells and antigen-presenting cells. Clarifies the different mechanisms of IgG activity at the level of the different model systems used, including human genetic, mouse, and in vitro Covers the role of antibodies in cancer, infectious disease, and autoimmunity and in the setting of monoclonal antibody therapy as well as naturally raised antibodies Color illustrations enhance explanations of the immune system

Antibody Fc

Antibody Fc
  • Author : Margaret Ackerman,Falk Nimmerjahn
  • Publisher : Academic Press
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 0123948185
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Summary : Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume ...

Antibody Fc

Antibody Fc
  • Author : Xiaojie Yu,Kavitha Baruah,Christopher N. Scanlan,Max Crispin
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 0123948185
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Summary : The antibody Fc region is posttranslationally modified by N-linked glycosylation. In immunoglobulin G (IgG), the processing of the glycans is restricted by the presence of extensive interaction with the protein surface. The resulting set of antibody glycoforms exhibit a range of effector functions. In this chapter, we outline the impact ...

Fc Localized Secondary Forces in Antigen antibody Precipitation

Fc Localized Secondary Forces in Antigen antibody Precipitation
  • Author : John D. Rodwell
  • Publisher : Unknown
  • Release Date : 1976
  • Total pages : 312
  • ISBN : 0123948185
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Summary : Download or read online Fc Localized Secondary Forces in Antigen antibody Precipitation written by John D. Rodwell, published by which was released on 1976. Get Fc Localized Secondary Forces in Antigen antibody Precipitation Books now! Available in PDF, ePub and Kindle....

Antibody Fc

Antibody Fc
  • Author : Peter Sun
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 0123948185
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Summary : Molecular mechanisms of antibody-mediated Fc receptor activation have long been an interest in both Fc receptor biology and antibody therapeutics. The structural efforts to elucidate antibody recognition by Fc receptors have led to the generation of several crystal structures of antibody Fc fragments complexed with Fc receptors. Collectively, these structures ...

Antibody Fc

Antibody Fc
  • Author : Theo Rispens,Gestur Vidarsson
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 0123948185
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Summary : Immunoglobulins are a group of closely related glycoproteins composed of 82 to 96% protein and 4 to 18% carbohydrate. In humans, there are five classes of immunoglobulins, which differ in heavy-chain structure. Immunoglobulin G (IgG) is the major class of immunoglobulins in blood and can be further subdivided in subclasses. The four subclasses of ...

Antibody Fc

Antibody Fc
  • Author : Victor Raúl Gómez Román,Joseph C. Murray,Louis M. Weiner
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 0123948185
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Summary : Antibody-dependent cellular cytotoxicity (ADCC), also called antibody-dependent cell-mediated cytotoxicity, is an immune mechanism through which Fc receptor-bearing effector cells can recognize and kill antibody-coated target cells expressing tumor- or pathogen-derived antigens on their surface. Numerous associations between ADCC activity, Fc receptor polymorphisms, and clinical outcomes have been observed in both ...

Antibody Fc

Antibody Fc
  • Author : Roy Jefferis
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 0123948185
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Summary : Diversity of antigen-binding specificity may be considered the hallmark of antibodies; however, the human IgG-Fc region also exhibits binding specificity for multiple ligands. Evolution of the IgG-Fc has resulted in the generation of interaction sites for endogenous (self) ligands that recruit and activate mechanisms facilitating the removal and destruction of ...

Antibody Fc Engineering Towards Better Therapeutics

Antibody Fc Engineering  Towards Better Therapeutics
  • Author : Tianlei Ying,Rui Gong
  • Publisher : Frontiers Media SA
  • Release Date : 2018-12-21
  • Total pages : 212
  • ISBN : 0123948185
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Summary : Download or read online Antibody Fc Engineering Towards Better Therapeutics written by Tianlei Ying,Rui Gong, published by Frontiers Media SA which was released on 2018-12-21. Get Antibody Fc Engineering Towards Better Therapeutics Books now! Available in PDF, ePub and Kindle....

Antibody Fc

Antibody Fc
  • Author : Marije B. Overdijk,Sandra Verploegen,Wim K. Bleeker,Paul W.H.I. Parren
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 0123948185
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Summary : Historically, lack of specificity for cancer cells has been a major problem in cancer treatment; however, the development of monoclonal antibodies (mAbs), which combine high specificity with multiple mechanisms of action (MoAs), started a revolution in anti-cancer treatment options which continues to date. As of January 2013, 15 major antibody products were ...

Fc Mediated Activity of Antibodies

Fc Mediated Activity of Antibodies
  • Author : Jeffrey V. Ravetch,Falk Nimmerjahn
  • Publisher : Springer Nature
  • Release Date : 2019-09-03
  • Total pages : 150
  • ISBN : 0123948185
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Summary : This volume explores several aspects of how antibodies mediate their activity in vivo, ranging from cancer immunotherapy to autoimmunity, infection, and vaccination. Divided into seven chapters, it provides in-depth insights into how antibodies and especially the antibody fragment crystallizable (Fc) domain modulate immune responses and antibody activity. The book begins ...

Antibody Fc

Antibody Fc
  • Author : Robert M. Anthony
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 0123948185
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Summary : IgG antibodies are highly potent molecules, with the unique ability to link foreign particles to innate immune cells. IgG antibodies recognize antigens with high affinity and bind cellular Fc receptors with low affinity individually. These interactions occur in the form of immune complexes, resulting in high-avidity interactions. In fact, the ...

Engineered Antibody Fragments for the Targeting and Imaging of Prostate Stem Cell Antigen PSCA Expressing Xenografts in Vivo by MicroPET

Engineered Antibody Fragments for the Targeting and Imaging of Prostate Stem Cell Antigen  PSCA   Expressing Xenografts in Vivo by MicroPET
  • Author : Victor Jeffrey Leyton
  • Publisher : Unknown
  • Release Date : 2008
  • Total pages : 526
  • ISBN : 0123948185
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Summary : Download or read online Engineered Antibody Fragments for the Targeting and Imaging of Prostate Stem Cell Antigen PSCA Expressing Xenografts in Vivo by MicroPET written by Victor Jeffrey Leyton, published by which was released on 2008. Get Engineered Antibody Fragments for the Targeting and Imaging of Prostate Stem Cell Antigen PSCA ...

Antibody Fc

Antibody Fc
  • Author : Joseph U. Igietseme,Xiaoping Zhu,Carolyn M. Black
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 0123948185
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Summary : Fc receptor (FcR)-dependent effector functions of antibodies contribute significantly to protective immunity against microbial pathogens and tumors. Therefore, FcR-mediated immunological processes constitute a key component of the immune system’s defense armamentaria for maintaining the biological and physiological integrity of the mammalian host who is yoked with frequent encounters ...

Antibody Fc

Antibody Fc
  • Author : Scott B. Halstead
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 0123948185
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Summary : While the benefits of antibody responses are widely known, pathogens are also able to exploit antibodies to facilitate cell entry and potentially alter the cellular response via interactions with Fc receptors. This phenomenon, known as antibody-dependent enhancement (ADE) of disease, is a factor in numerous human and veterinary diseases. It ...

Antibody Fc

Antibody Fc
  • Author : George J. Weiner
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-08-06
  • Total pages : 358
  • ISBN : 0123948185
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Summary : Monoclonal antibodies (mAbs), including rituximab, are now a mainstay in the therapy of cancer. Despite their undeniable therapeutic value, there is much we do not fully understand about the mechanisms of action responsible for their anti-tumor effects. These mechanisms are often studied in isolation. In this chapter, we will review ...