Animal Models in Cancer Drug Discovery

Written By Asfar Azmi
Animal Models in Cancer Drug Discovery
  • Publsiher : Academic Press
  • Release : 16 April 2019
  • ISBN : 0128147059
  • Pages : 470 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Animal Models in Cancer Drug Discovery written by Asfar Azmi which was release on 16 April 2019, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field. Encompasses discussions on innovative animal models, xenograft, genetic models, primary models, organoid systems, humanized and other models in modern biology paradigms that are enhancing research in the field of drug discover Covers the use of these models in personalized medicine, immunotherapy, toxicology, pre-IND assessments and related drug development arenas Presents protocols, procedures, and a comprehensive glossary to help new readers understand technical terms and specialized nomenclature

Animal Models in Cancer Drug Discovery

Animal Models in Cancer Drug Discovery
  • Author : Asfar Azmi,Ramzi M. Mohammad
  • Publisher : Academic Press
  • Release Date : 2019-04-16
  • Total pages : 470
  • ISBN : 0128147059
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Summary : Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on ...

Tumor Models in Cancer Research

Tumor Models in Cancer Research
  • Author : Beverly A. Teicher
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-12-01
  • Total pages : 693
  • ISBN : 0128147059
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Summary : The past 6 years since the first edition of this book have seen great progress in the development of genetically engineered mouse (GEM) models of cancer. These models are finding an important role in furthering our understanding of the biology of malignant disease. A comfortable position for GEM models in the ...

Tumor Models in Cancer Research

Tumor Models in Cancer Research
  • Author : Beverly A. Teicher
  • Publisher : Humana Press
  • Release Date : 2001-11-07
  • Total pages : 690
  • ISBN : 0128147059
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Summary : Beverly A. Teicher and a panel of leading experts comprehensively describe for the first time in many years the state-of-the-art in animal tumor model research. The wide array of models detailed form the basis for the selection of compounds and treatments that go into clinical testing of patients, and include ...

Animal Models for Human Cancer

Animal Models for Human Cancer
  • Author : Marianne I. Martic-Kehl,Pius August Schubiger
  • Publisher : John Wiley & Sons
  • Release Date : 2016-05-18
  • Total pages : 272
  • ISBN : 0128147059
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Summary : Based on results from the past ten years, this ready reference systematically describes how to prepare, carry out, and evaluate animal studies for cancer therapies, addressing the widely recognized lack of reliable and reproducible results. Following a short historical introduction and a discussion of the ethics surrounding animal experiments, the ...

Molecular Cancer Therapeutics

Molecular Cancer Therapeutics
  • Author : George C. Prendergast
  • Publisher : John Wiley & Sons
  • Release Date : 2004-04-02
  • Total pages : 368
  • ISBN : 0128147059
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Summary : Molecular Cancer Therapeutics covers state-of-the-art strategies to identify and develop cancer drug target molecules and lead inhibitors for clinical testing. It provides a thorough treatment of drug target discovery, validation, and development. The introductory chapters provide an overview of pathways to discovery and development of molecular cancer therapeutics. Subsequent chapters ...

Drug Discovery in Pancreatic Cancer

Drug Discovery in Pancreatic Cancer
  • Author : Haiyong Han,Paul Grippo
  • Publisher : Springer Science & Business Media
  • Release Date : 2010-03-11
  • Total pages : 297
  • ISBN : 0128147059
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Summary : Pancreatic cancer is the fourth leading cause of cancer death in the United States. Every year, about 33,700 people in the United States will be diagnosed with pancreatic cancer and over 32,000 patients will die from the disease. The median survival of patients with advanced pancreatic cancer is about 6-months. This dismal ...

Cytokines in the Genesis and Treatment of Cancer

Cytokines in the Genesis and Treatment of Cancer
  • Author : Michael A. Caligiuri,Michael T. Lotze
  • Publisher : Springer Science & Business Media
  • Release Date : 2007-09-19
  • Total pages : 482
  • ISBN : 0128147059
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Summary : Cytokines in the Genesis and Treatment of Cancer provides a comprehensive picture of the dual role of host responses in promoting and inhibiting tumor progression. This volume represents an important investigation into the emerging intersection of cancer biology and cancer immunology. The book brings together an impressive array of internationally ...

Tumor Suppressor Genes in Human Cancer Cancer Drug Discovery and Development

Tumor Suppressor Genes in Human Cancer  Cancer Drug Discovery and Development
  • Author : David E. Fisher
  • Publisher : Unknown
  • Release Date : 2001
  • Total pages : 212
  • ISBN : 0128147059
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Summary : While the war against cancer has seen great advances in our understanding of cell proliferation and its regulation at the molecular level, the translation of this knowledge into effective therapies has lagged well behind. In Tumor Suppressor Genes in Human Cancer, David Fisher, MD, PhD, and an authoritative panel of ...

In vivo Models for Drug Discovery

In vivo Models for Drug Discovery
  • Author : José Miguel Vela,Rafael Maldonado,Michel Hamon
  • Publisher : John Wiley & Sons
  • Release Date : 2014-08-11
  • Total pages : 594
  • ISBN : 0128147059
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Summary : This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases. Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on ...

Protein Tyrosine Kinases

Protein Tyrosine Kinases
  • Author : Doriano Fabbro,Frank McCormick
  • Publisher : Springer Science & Business Media
  • Release Date : 2006
  • Total pages : 290
  • ISBN : 0128147059
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Summary : Protein tyrosine kinases as targets for cancer and other indications / Mark Pearson, Carlos Garcia-Echeverria, Doriano Fabbro -- Inhibitors of signaling interfaces: targeting Src homology 2 domains in drug discovery / Carlos Garcia-Echeverria -- PI 3-kinase inhibition: a target for therapeutic intervention / Peter M. Finan, Stephen G. Ward -- Src as a target ...

Tumor Suppressor Genes in Human Cancer

Tumor Suppressor Genes in Human Cancer
  • Author : David E. Fisher
  • Publisher : Humana Press
  • Release Date : 2010-10-28
  • Total pages : 386
  • ISBN : 0128147059
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Summary : David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell ...

In vivo Models for Drug Discovery

In vivo Models for Drug Discovery
  • Author : José Miguel Vela,Rafael Maldonado,Michel Hamon
  • Publisher : John Wiley & Sons
  • Release Date : 2014-07-31
  • Total pages : 594
  • ISBN : 0128147059
GET BOOK

Summary : This one-stop reference is the first to present the complete picture -- covering all relevant organisms, from single cells to mammals, as well as all major disease areas, including neurological disorders, cancer and infectious diseases. Addressing the needs of the pharmaceutical industry, this unique handbook adopts a broad perspective on ...

Molecular Diagnostics and Treatment of Pancreatic Cancer

Molecular Diagnostics and Treatment of Pancreatic Cancer
  • Author : Asfar Azmi
  • Publisher : Elsevier
  • Release Date : 2014-04-14
  • Total pages : 458
  • ISBN : 0128147059
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Summary : Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and ...

Anticancer Drug Development Guide

Anticancer Drug Development Guide
  • Author : Beverly A. Teicher,Paul A. Andrews
  • Publisher : Springer Science & Business Media
  • Release Date : 2004-02-01
  • Total pages : 451
  • ISBN : 0128147059
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Summary : This unique volume traces the critically important pathway by which a "molecule" becomes an "anticancer agent. " The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus ...

Molecular Diagnostics and Treatment of Pancreatic Cancer

Molecular Diagnostics and Treatment of Pancreatic Cancer
  • Author : Asfar Azmi
  • Publisher : Academic Press
  • Release Date : 2014-04-17
  • Total pages : 446
  • ISBN : 0128147059
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Summary : Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and ...