Animal Models for the Study of Human Disease

Written By P. Michael Conn
Animal Models for the Study of Human Disease
  • Publsiher : Academic Press
  • Release : 20 June 2017
  • ISBN : 0128096993
  • Pages : 1198 pages
  • Rating : 4/5 from 21 reviews
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Read or download book entitled Animal Models for the Study of Human Disease written by P. Michael Conn which was release on 20 June 2017, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy researchers across biomedical and biological sciences. Offering easily searchable advantages and disadvantages for each animal model and organized by disease topics, this resource aids researchers in finding the best animal model for research in human disease. Organized by disease orientation for ease of searchability Provides information on locating resources, animal alternatives, and animal ethics Covers a broad range of animal models used in research for human disease Contributed by leading experts across the globe Expanded coverage of diabetes and neurological diseases

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : P. Michael Conn
  • Publisher : Academic Press
  • Release Date : 2017-06-20
  • Total pages : 1198
  • ISBN : 0128096993
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Summary : Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy researchers across biomedical and biological sciences. Offering easily searchable advantages and disadvantages for each animal model ...

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Judith Axler Turner
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-29
  • Total pages : 1108
  • ISBN : 0128096993
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Summary : Identifying and selecting the most appropriate animal model is a challenge, but the U.S. Federal Government’s National Institutes of Health, has supported several efforts to make the job of finding disease models easier. These efforts began with support for databases about specific species, and have graduated to support ...

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Daniel Butzke,Barbara Grune,Josephine Kugler,Michael Oelgeschläger,Andrea Seiler,Dana Sittner,Manfred Liebsch,Andreas Luch
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-29
  • Total pages : 1108
  • ISBN : 0128096993
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Summary : The first years of the 21st century have seen an unparalleled progress in biomedical sciences. Several dogmata that haunted scientific debate for decades were easily abandoned, and there is a fundamental shift away from eminence-based toward evidence-based assessment of preclinical models, probing their true value in predicting clinical outcomes of ...

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Robert H. Miller,Sharyl Fyffe-Maricich,Andrew V. Caprariello
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-29
  • Total pages : 1108
  • ISBN : 0128096993
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Summary : The most common demyelinating disease of the central nervous system (CNS) in the young adult population is multiple sclerosis (MS). MS is characterized by the focal loss of myelin sheaths in the brain and in the spinal cord of patients that is correlated with elevated activity of the immune system ...

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Yoichi Gondo
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-29
  • Total pages : 1108
  • ISBN : 0128096993
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Summary : To create and establish mutant mice as models for human diseases and traits, various forward and reverse genetics tools are currently available. Newly developed tools of high-throughput identification of novel mutations and site-directed mutagenesis, or gene targeting, in the mouse genome have caused forward and reverse genetics, respectively, to rapidly ...

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Lucas M. Chaible,Denise Kinoshita,Marcus A. Finzi Corat,Maria L. Zaidan Dagli
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-29
  • Total pages : 1108
  • ISBN : 0128096993
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Summary : Genetically modified animals were created about 30 years ago, and are considered good models of human diseases. In this chapter, the types of genetically engineered mice, such as transgenic, knockout conditional knockout, and knockin animals, and the general techniques on how to obtain them are described. In addition, the available genetically ...

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Gideon P. Smith
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-29
  • Total pages : 1108
  • ISBN : 0128096993
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Summary : Although fibrosis can occur as part of normal wound healing, dysregulated fibrosis can affect almost any organ and results in severe dysfunction. Despite the variety of human disease of which this is a feature these diseases remain poorly understood due in part to the slow largely asymptomatic onset. Animal models ...

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Joachim Wistuba,Steffi Werler,Lars Lewejohann
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-29
  • Total pages : 1108
  • ISBN : 0128096993
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Summary : Klinefelter syndrome (KS) is a frequent (0.2%) sex chromosomal disorder in males presenting with a 47,XXY karyotype. This condition is associated with infertility, hypogonadism, and metabolic and cognitive impairments. As experimental research is restrictive in patients, animal models for KS are needed to explore its molecular and genetic basis. Supernumerary X ...

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Jerrold Tannenbaum
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-29
  • Total pages : 1108
  • ISBN : 0128096993
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Summary : This chapter presents an overview of ethical principles that are essential for the proper conduct, and the continuing progress, of animal research aimed at understanding human disease. The chapter identifies fundamental principles of animal research ethics, and discusses ethical and empirical foundations of these principles. Guidelines are offered for applying ...

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Sara I. Ruiz,Elizabeth E. Zumbrun,Aysegul Nalca
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-29
  • Total pages : 1108
  • ISBN : 0128096993
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Summary : As the threat of exposure to emerging and reemerging viruses within a naive population increases, it is vital that the basic mechanisms of pathogenesis and immune response be thoroughly investigated. By using animal models in this endeavor, the response to viruses can be studied in a more natural context to ...

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Jitka Sviglerova,Jitka Kuncova,Milan Stengl
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-29
  • Total pages : 1108
  • ISBN : 0128096993
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Summary : Impairment, altered function or altered requirements of various organs lead to corresponding changes of cardiovascular system, especially its central organ, the heart. The heart adapts to the altered conditions and requirements by intensive remodeling. The remodeling is usually very complex, including both structural (e.g. hypertrophy, fibrosis) and functional (e....

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Lina Badimon,Laura Casani,Gemma Vilahur
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-29
  • Total pages : 1108
  • ISBN : 0128096993
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Summary : Experimental approaches to understand the pathophysiology of atherosclerosis and thrombosis involve the combination of both cellular and animal approaches. Animals have been instrumental in biomedical research in order to provide a better understanding on the mechanisms that have already been outlined in in vitro studies. Atherosclerosis studies were firstly carried ...

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Lixin Kan
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-29
  • Total pages : 1108
  • ISBN : 0128096993
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Summary : Bone disorders have a major impact on general population and cover a broad spectrum of diseases. At one end of the spectrum are the common disorders that are featured with age related progressive degeneration, and at the other end are the rare but serious congenital abnormities. Deeper understanding of the ...

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Mengqi Chen,Doris Kretzschmar,Giuseppe Verdile,Michael Lardelli
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-29
  • Total pages : 1108
  • ISBN : 0128096993
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Summary : Alzheimer’s disease (AD) is a major and increasing burden on families, communities, and national health budgets. Despite intensive and extended research, there is still widespread debate about its cause(s), and no effective treatments exist. Familial (inherited, mainly early onset) and sporadic (mainly late onset) forms of the disease ...

Animal Models for the Study of Human Disease

Animal Models for the Study of Human Disease
  • Author : Atsushi Mizoguchi,Akira Andoh
  • Publisher : Elsevier Inc. Chapters
  • Release Date : 2013-05-29
  • Total pages : 1108
  • ISBN : 0128096993
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Summary : Inflammatory bowel disease (IBD) is a chronic, relapsing intestinal inflammatory condition with increasing incidence and prevalence around the world. Conventional and biological therapies have been successfully, or unsuccessfully, applied for the treatment of IBD and several new biological therapies are currently in clinical development. So far, more than 69 kinds of ...