AGO Driven Non Coding RNAs

Written By Bibekanand Mallick
AGO Driven Non Coding RNAs
  • Publsiher : Academic Press
  • Release : 20 January 2019
  • ISBN : 0128156708
  • Pages : 387 pages
  • Rating : 4/5 from 21 reviews
GET THIS BOOKAGO Driven Non Coding RNAs


Read or download book entitled AGO Driven Non Coding RNAs written by Bibekanand Mallick which was release on 20 January 2019, this book published by Academic Press. Available in PDF, EPUB and Kindle Format. Book excerpt: The ‘RNA world’ hypothesis that proposed RNA molecules as the first form of genetic material was put forwarded in the late 1980s but got impetus only recently when high-throughput sequencing technologies began unearthing new types of non-coding RNA (ncRNA) transcripts in higher eukaryotes. Till then, research on ncRNAs were primarily confined to transfer RNAs and, ribosomal RNAs, which act as the messengers of the protein synthesis and allow translation of genetic information encoded by DNA into proteins. In recent years, the integration of high-throughput genomic technologies with molecular biology and omics sciences have revolutionized the fields of ncRNA research by identifying the hidden treasures of several new types of ncRNAs encoded in the genomes of several organisms and decrypting their versatile roles in gene expression and epigenetics. Among these, two small endogenous ncRNAs, namely microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs) that drive argonaute (AGO) family of proteins namely Ago and Piwi respectively and silence the expression of genes have geared up molecular and disease biology research in recent years. Both miRNAs and piRNAs are expressed in higher eukaryotes, including human and act as cellular rheostats by regulating the expression of significant fraction of genes encoded in the genomes. The aberrant expressions of these small ncRNAs within the cells cause various abnormalities and diseases including cancer. Manipulating their aberrant expression or function can serve as potential novel diagnostic/prognostic biomarkers and bring in new therapeutic strategies for multiple human diseases. This can be further translated from bench-side to clinic for improving human health. This book captures the essence of the pioneering work of some of the world’s leading researchers showcasing the scientific excitements surrounding the evolving regulatory roles of miRNAs and piRNAs highlighting their potential towards the diagnosis and therapeutics of various diseases. The book is geared towards scientists, students, and will particularly appeal to active investigators in RNA biology, molecular biology, cancer research as well as clinicians and will provide them a comprehensive view of recent discoveries and research progresses to utilize miRNAs, piRNAs and their interacting proteins, Ago and Piwi for diagnosis, prognosis and therapeutics of diseases. Provides a unified cutting-edge resource for both miRNAs and piRNAs, two promising AGO-clade small ncRNAs, their functions and potential applications Showcase high-throughput technologies and other approaches for discovery of these small ncRNAs and their targets Unveils the diverse molecular mechanisms by which miRNAs and piRNAs regulate gene expression in animal cells Showcase recent discoveries on involvement of Argonaute and Piwi proteins in different biological processes and diseases as well as their possible use in diagnosis Report breakthroughs in the use of small ncRNAs for diagnosis and personalized therapy

AGO Driven Non Coding RNAs

AGO Driven Non Coding RNAs
  • Author : Bibekanand Mallick
  • Publisher : Academic Press
  • Release Date : 2019-01-20
  • Total pages : 387
  • ISBN : 0128156708
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Summary : The ‘RNA world’ hypothesis that proposed RNA molecules as the first form of genetic material was put forwarded in the late 1980s but got impetus only recently when high-throughput sequencing technologies began unearthing new types of non-coding RNA (ncRNA) transcripts in higher eukaryotes. Till then, research on ncRNAs were primarily ...

Essentials of Cancer Genomic Computational Approaches and Precision Medicine

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  • Publisher : Springer Nature
  • Release Date : 2020-03-20
  • Total pages : 499
  • ISBN : 0128156708
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Summary : This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent ...

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Summary : Download or read online Genome Research written by , published by which was released on 2009. Get Genome Research Books now! Available in PDF, ePub and Kindle....

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  • Release Date : 2018-11-13
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  • ISBN : 0128156708
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Summary : Until about a decade ago, the non-coding part of the genome was considered without function. RNA sequencing studies have shown, however, that a considerable part of the non-coding genome is transcribed and that these non-coding RNAs (nc-RNAs) can regulate gene expression. Almost on weekly basis, new findings reveal the regulatory ...

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  • Publisher : Wiley-Interscience
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Summary : To understand the brain and its devastating diseases, we need to reveal the mechanisms that produce it and the ways in which it can constantly change throughout a lifetime. This book features a timely and insightful discussion between developmental neurobiologists and clinicians who deal with disorders of the nervous system. ...

Regulatory RNAs in the Nervous System

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  • Publisher : Frontiers Media SA
  • Release Date : 2015-05-08
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  • ISBN : 0128156708
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Summary : Until about a decade ago, the non-coding part of the genome was considered without function. RNA sequencing studies have shown, however, that a considerable part of the non-coding genome is transcribed and that these non-coding RNAs (nc-RNAs) can regulate gene expression. Almost on weekly basis, new findings reveal the regulatory ...

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  • Author : Biochemical Society (Great Britain)
  • Publisher : Unknown
  • Release Date : 2008
  • Total pages : 212
  • ISBN : 0128156708
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Summary : Download or read online Transactions written by Biochemical Society (Great Britain), published by which was released on 2008. Get Transactions Books now! Available in PDF, ePub and Kindle....

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  • Release Date : 2009
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Summary : Download or read online Philosophical Transactions of the Royal Society of London written by , published by which was released on 2009. Get Philosophical Transactions of the Royal Society of London Books now! Available in PDF, ePub and Kindle....

Proceedings of the National Academy of Sciences of the United States of America

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  • Author : National Academy of Sciences (U.S.)
  • Publisher : Unknown
  • Release Date : 2002
  • Total pages : 212
  • ISBN : 0128156708
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Summary : Download or read online Proceedings of the National Academy of Sciences of the United States of America written by National Academy of Sciences (U.S.), published by which was released on 2002. Get Proceedings of the National Academy of Sciences of the United States of America Books now! Available in PDF, ...

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Summary : Download or read online New Technology Japan written by , published by which was released on 1996. Get New Technology Japan Books now! Available in PDF, ePub and Kindle....

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  • Publisher : Wiley-Blackwell
  • Release Date : 2008-04-14
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  • ISBN : 0128156708
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Summary : Leading researchers in the life sciences and engineers involved in research of transport phenomena in biological systems have contributed chapters that identify, analyze, and modify the control and regulation mechanisms of transport phenomena in biological systems, with particular emphasis on the cardiac system. Included in the contributions to this volume ...

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Summary : Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. The definitive guide to treating neurologic and psychiatric disorders with drugs and other approaches Fully updated with the latest research and drugs, Nestler, ...

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  • Release Date : 2003-11-21
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Summary : Encompasses key developments in immunoinformatics, including immunological databases, sequence analysis, structure modelling, mathematical modelling of the immune system, simulation of laboratory experiments, statistical support for immunilogical experimentation and immuogenomics....

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  • Release Date : 2002
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Summary : Download or read online Annals of Periodontology written by , published by which was released on 2002. Get Annals of Periodontology Books now! Available in PDF, ePub and Kindle....

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  • Author : Anonim
  • Publisher : Unknown
  • Release Date : 2007
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Summary : Download or read online Seed written by , published by which was released on 2007. Get Seed Books now! Available in PDF, ePub and Kindle....